Impact of a functionalized olive oil extract on the uterus and the bone in a model of postmenopausal osteoporosis

Keiler, Annekathrin Martina; Zierau, Oliver; Bernhardt, Ricardo; Scharnweber, Dieter; Lemonakis, Nikolaos; Termetzi, Aikaterini; Skaltsounis, Léandros; Vollmer, Günter; Halabalaki, Maria

doi:10.1007/s00394-013-0609-4

Cited by 34 publications

(29 citation statements)

References 40 publications

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“…Dans le cadre de l'exploration de l'effet biologique éven-tuel des produits de l'olivier, Keiler et al (2013) ont testé l'impact d'un extrait polyphénolique d'huile d'olive extra vierge, administré à la dose de 800 mg/kg de régime chez la rate ovariectomisée, sans toutefois pouvoir mettre en exergue une quelconque efficacité sur le squelette. À l'inverse, dans un modèle expérimental d'ostéoporose sénile associant castration et inflammation, Puel et al (2006) ont démontré que la consommation d'oleuropéine (ester formé d'une molécule d'hydroxytyrosol et d'acide élénolique), à la dose de 0,015 % dans le régime alimentaire, permet une protection efficace du squelette contre les effets délétères de l'inflammation (cumulés à ceux induits par la carence oestrogénique), principalement en améliorant les marqueurs de l'inflammation tels que le poids de la rate et la concentration plasmatique en alpha-1-glycoprotéine.…”

Section: Cas Des Polyphénols De L'huile D'oliveunclassified

Huile d’olive et santé osseuse

Coxam

Wauquier

Darie

et al. 2014

OCL

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Résumé -L'ostéoporose représente un problème majeur de santé. La prise en charge classique de cette pathologie, essentiellement curative, est destinée aux personnes qui ont exprimé la maladie. Une telle stratégie ciblant la personne âgée souffrant d'ostéoporose sévère s'avère trop tardive. En fait, le traitement idéal de l'ostéoporose, pour être efficace, doit être oral, dénué d'effet secondaire, et surtout précoce de façon à inhiber très en amont le processus de perte osseuse. C'est pourquoi les stratégies de prévention visant à réduire les risques d'ostéoporose doivent être développées et instaurées. Ainsi, le concept d'une alimentation saine, fournissant des quantités suffisantes de différents nutriments potentiellement ostéoprotecteurs, mérite d'être mentionné. Dans cette optique, les olives ou l'huile d'olive vierge sont des aliments fonctionnels intéressants qui, en plus de leur richesse en acides gras mono-insaturés (acide oléique), contiennent plusieurs composants polyphénoliques ayant des propriétés biologiques spécifiques. Ils pourraient ainsi constituer des éléments efficaces pour prévenir l'ostéoporose, comme en témoignent les données de la littérature. Mots clés :Huile d'olive / polyphénols / acides gras / santé osseuse Abstract -Olive oil and bone health. Osteoporosis represents a major healthcare burden. Current pharmacologic approaches to osteoporosis are directed at those who already have the disease, which is often too late for the aged person with severe osteoporosis. Actually, the ideal therapy for to be effective for osteoporosis prevention needs to be oral, to be safe, and to inhibit bone loss as early as possible. This is why broad-based preventive strategies designed to lower the risks of osteoporosis need to be established and implemented. Thus, the concept of a healthy diet providing adequate amounts of various potent micronutrients deserves mention. In this light, olives or virgin olive oil are functional foods which besides having a high level of MUFA, the oleic acid, contains multiple minor phenolic components with specific biological properties. They could thus be a key component of successful dietary manipulations to prevent osteoporosis, as shown by many scientific publications.

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Section: Cas Des Polyphénols De L'huile D'oliveunclassified

Huile d’olive et santé osseuse

Coxam

Wauquier

Darie

et al. 2014

OCL

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“…While the total polyphenolic fraction (TFP) only mildly increased the uterine wet weight (490.7±53.7 vs. 432.7±23 mg/kg body weight; P=0.058), it regulated estrogen response genes in the uterus (progesterone receptor, antigen identified by monoclonal antibody Ki67, complement C3). These results suggested that the administration of extra virgin olive oil polyphenols regulated uterine estrogen response marker genes in an E 2 -agonistic manner (42).…”

Section: Discussionmentioning

confidence: 90%

“…Traditional Chinese medicinal herbs such as Rehmannia glutinosa and Ferula, or oils extracted from various plant species, which have similar though milder effects to that of estradiol-17β benzoate, may be associated with the maintenance of bone mass in the post-menopausal period due to their putative function as osteoprotective agents (42).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, olive oil also has anti-cancer effect as there has been reported that olive oil contains a number of compounds which by their antioxidative action reduce the risk of cell damage and their consequential uncontrolled growth and division (43). Therefore, olive oil may be more suitable to the treatment of osteoporosis associated with postoperative gynecological malignancies, displaying desirable estrogenic effects but with fewer undesirable side effects.…”

Section: Discussionmentioning

confidence: 99%

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Olive oil exhibits osteoprotection in ovariectomized rats without estrogenic effects

Zheng

Huang

Zheng

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. The present study was designed to evaluate the effect of olive oil on bone and uterus in ovariectomized rats. A total of 34 surgically ovariectomized or sham-operated virgin Sprague-Dawley rats were divided into four groups: i) Sham-operated control rats (sham group); ii) Ovariectomized rats (OVX group); iii) Olive oil-supplemented ovariectomized rats (olive group); and iv) Diethylstilbestrol-supplemented ovariectomized rats (E 2 group). At 12 weeks following left ventricular blood sacrificed to detect plasma estradiol (E 2 ), interleukin-1β (IL-1β) and IL-6 levels. Bone mineral density (BMD) of the lumbar spine was evaluated using dual-energy X-ray absorptiometry, and the left femur proximal 1/3 slices were observed using transmission electron microscopy. Uterine wet weight and the uterus index (ratio of uterine wet weight and body weight) were compared, and the uterine endometrium was observed using a light microscope. In the OVX group, serum E 2 was significantly lower and IL-1β and IL-6 levels were significantly higher compared with the sham group. By contrast, serum E 2 levels increased and IL-1β levels decreased in the olive group, but showed no significant difference compared with the sham group. The lumbar spine BMD in the olive group was increased compared with OVX group. Electron microscopy revealed sparse collagen fibers in the OVX group, with decreased density and multi-cavity, showing pathological features of osteoporosis. By contrast, the situation was improved in the E 2 and olive groups, in which organelles such as the rough endoplasmic reticulum, mitochondria and Golgi apparatus were visible and active. Compared with the sham group rats, the uterine wet weight and uterine index decreased in the OVX and olive groups; however, no statistically significant difference was observed in the E 2 group. Furthermore, endometrial hyperplasia was not observed in the olive group, which were apparently different from E 2 group. The present results suggest that olive oil can effectively reduce bone loss in ovariectomized rats, and with no or only mild effects on the uterine endothelium.

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“…A leading hypotheses of what drives this difference is the adherence to the so-called Mediterranean diet; however, recent evidence suggests that it is likely the daily consumption of olive oil that is associated with reductions in osteoporosis in these regions [3, 5–7, 9, 10]. One hypothesis suggests that the phenols in olive oil may play a role in the mechanism of action through their antioxidative, pro-vitamin D properties; however, there is no specific compound that appears to be singled out [4–6, 11–15]. …”

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confidence: 99%

Levels of bioactive lipids in cooking oils: olive oil is the richest source of oleoyl serine

Bradshaw

Leishman

2015

Journal of Basic and Clinical Physiology and Pharmacology

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Background Rates of osteoporosis are significantly lower in regions of the world where olive oil consumption is a dietary cornerstone. Olive oil may represent a source of oleoyl serine (OS), which showed efficacy in animal models of osteoporosis. Here, we tested the hypothesis that OS as well as structurally analogous N-acyl amide and 2-acyl glycerol lipids are present in the following cooking oils: olive, walnut, canola, high heat canola, peanut, safflower, sesame, toasted sesame, grape seed, and smart balance omega. Methods Methanolic lipid extracts from each of the cooking oils were partially purified on C-18 solid-phase extraction columns. Extracts were analyzed with high-performance liquid chromatography-tandem mass spectrometry, and 33 lipids were measured in each sample, including OS and bioactive analogs. Results Of the oils screened here, walnut oil had the highest number of lipids detected (22/33). Olive oil had the second highest number of lipids detected (20/33), whereas grape-seed and high-heat canola oil were tied for lowest number of detected lipids (6/33). OS was detected in 8 of the 10 oils tested and the levels were highest in olive oil, suggesting that there is something about the olive plant that enriches this lipid. Conclusions Cooking oils contain varying levels of bioactive lipids from the N-acyl amide and 2-acyl glycerol families. Olive oil is a dietary source of OS, which may contribute to lowered prevalence of osteoporosis in countries with high consumption of this oil.

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Impact of a functionalized olive oil extract on the uterus and the bone in a model of postmenopausal osteoporosis

Abstract: The administration of extra virgin olive oil polyphenols regulated uterine estrogen response marker genes in an E2-agonistic manner. The bone loss induced by estrogen ablation was not mitigated by treatment with the polyphenolic extract.

Cited by 34 publications

References 40 publications

Huile d’olive et santé osseuse

Huile d’olive et santé osseuse

Olive oil exhibits osteoprotection in ovariectomized rats without estrogenic effects

Levels of bioactive lipids in cooking oils: olive oil is the richest source of oleoyl serine

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