Impact of a non‐fluoridated microcrystalline hydroxyapatite dentifrice on enamel caries progression in highly caries‐susceptible orthodontic patients: A randomized, controlled 6‐month trial

Schlagenhauf, Ulrich; Kunzelmann, Karl‐Heinz; Hannig, Christian; May, Theodor W.; Hösl, Helmut; Gratza, Mario; Viergutz, Gabriele; Nazet, Marco; Schamberger, Sebastian; Proff, Peter

doi:10.1111/jicd.12399

Cited by 54 publications

(115 citation statements)

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“…[15]). Among these calcium-based cariespreventive agents, casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) has been studied intensively [7,9,10,16], while recently several studies have been published investigating synthetic particulate HAP (Ca 5 (PO 4 ) 3 (OH)) as another calcium phosphate-based compound [17][18][19][20]. HAP has often been proposed as a biomimetic agent for directly filling up micropores on demineralized tooth surfaces [17] and by reducing initial bacterial colonization on enamel surfaces [18].…”

Section: Introductionmentioning

confidence: 99%

“…HAP has often been proposed as a biomimetic agent for directly filling up micropores on demineralized tooth surfaces [17] and by reducing initial bacterial colonization on enamel surfaces [18]. However, in patients exhibiting high plaque scores the primary mode of action of HAP as an oral care agent may be to act as a calcium phosphate reservoir when deposited in oral biofilms, potentially releasing Ca 2+ and (hydrogen) phosphate ions H 2 PO 4 − , HPO 4 2− and PO 4 3− upon bacterial acid challenge and thus maintaining a state of higher saturation with respect to these ions at the tooth surface [19,20].…”

Section: Introductionmentioning

confidence: 99%

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Ca2+ release and buffering effects of synthetic hydroxyapatite following bacterial acid challenge

et al. 2020

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Background: Synthetic particulate hydroxyapatite (HAP; Ca 5 (PO 4 ) 3 (OH)) is used as ingredient in oral care products but its effects on cariogenic biofilms are not clear yet. The primary mode of action of HAP may be acting as a calcium phosphate reservoir when deposited in oral biofilms and release Ca 2+ and (hydrogen) phosphate ions upon bacterial acid challenge. The aim of this in vitro study was to test this hypothesis by investigating release of Ca 2+ ions and potential buffering effects from HAP upon bacterial acid challenge in planktonic cultures and biofilms of Streptococcus mutans. Methods: Planktonic cultures of S. mutans were grown in BHI broth with 1% sucrose or with additional 5% HAP or 5% silica for up to 48 h. Separately, biofilms of S. mutans were grown in BHI for 72 h in total. After 24 h of this biofilm culture, either BHI alone or BHI with additional 0.5% HAP or 0.5% silica was added. After 48 h, BHI with 1% sucrose was added to allow bacterial acid formation. Ca 2+ release was determined colorimetrically and pH measurements were performed using a pH electrode. For statistical analysis, non-parametrical procedures were applied (n ≥ 10; Mann-Whitney U test; α = 0.05).Results: Relevant release of Ca 2+ was only evident in planktonic cultures or biofilms with HAP but not in both other groups (p ≤ 0.001). In suspended biofilms with HAP, median pH was 4.77 after 72 h and about 0.5 pH units higher as compared to both other groups (4.28 or 4.32, respectively; p ≤ 0.001).Conclusions: Under the tested conditions, synthetic HAP releases Ca 2+ ions upon bacterial acid challenge and may also show some buffering capacity but further studies are needed to investigate whether the concentrations tested here can also be reached clinically in dental biofilms.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ca2+ release and buffering effects of synthetic hydroxyapatite following bacterial acid challenge

et al. 2020

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“…13 HAP particles interact with enamel surfaces as shown in vitro, 14 in situ, 15 and in vivo. 16,17 Clinical studies have shown effects of HAP-based toothpastes, for example, in prevention of enamel caries 17 and reducing dentin hypersensitivity, 18 as well as in improving periodontal health. 19 Additionally, HAP particles reduce bacterial colonization to enamel surfaces in situ similar to chlorhexidine without having antibacterial effects, but showing antiadherent properties.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Effects of a Hydroxyapatite-Based Oral Care Gel on the Calcium and Phosphorus Levels of Dental Plaque

Sudradjat¹,

Meyer

Loza

et al. 2020

Eur J Dent

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Objectives Particulate hydroxyapatite (HAP; Ca5(PO4)3(OH)) is a biomimetic oral care ingredient. One mode of action in caries-susceptible individuals may be the adhesion/incorporation of HAP into dental plaque. Therefore, the aim of this in vivo study was to analyze the 3-day effects of a newly developed hydroxyapatite-based oral care gel on the calcium and phosphorus levels within the dental plaque of children. Materials and Methods This study was conducted in Kebon Padangan at Bali in Indonesia. Thirty-four children (mean age, 8.9 years; mean DMF-T [decayed, missing, and filled teeth; permanent teeth], 0.6; mean dmft-t [primary teeth] 4.5) were included in the study. The gel was applied thrice for 3 days by an experienced dentist. Dental plaque was collected at baseline and after the study. Levels of calcium and phosphorus of plaque samples were analyzed by energy-dispersive X-ray spectroscopy. Statistical Analysis Medians for both calcium and phosphorus levels were calculated (baseline and 3-day application of HAP-gel). Results The calcium level increased after 3 days of application of the HAP-gel from 0.25 wt% (median) to 0.40 wt% (median), while the phosphorus level increased from 1.17 wt% (median) to 1.41 wt% (median). However, variations in both calcium and phosphorus levels measured in the pooled dental plaque samples were high. Conclusion Within the limitations of the study, the 3-day application of the oral HAP-gel in children increased the median of both calcium and phosphorus levels in plaque. Consequently, a positive influence on the remineralization/demineralization process is very likely.

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“…Principal dermatological features found in 200 patients included: xerosis, acne, alopecia, caries, hypertrichosis, and Russell's sign in bulimia nervosa and xerosis and hypertrichosis, acne, alopecia, and caries in AN. 30 As for children and adolescents, Schulze et al 32 observed xerosis of the skin, diffuse hypertrichosis, acrocyanosis, scars, diffuse effluvium, artifacts, brittle nails, and onychophagia. Significant association was found between the presence of hypertrichosis and the existence of amenorrhea or a body mass index of less than 16 kg/m 2 .…”

Section: Study Of Dermatological Statusmentioning

confidence: 99%

“…They do not show potential risks associated with fluorides, but can facilitate erosion/caries control. 30…”

Section: Study Of Oral Manifestationsmentioning

confidence: 99%

Anorexia Nervosa with Vomiting Episodes: Dermatological and Oral Complications

et al. 2020

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The aim of the study was to highlight the aspect of oral and cutaneous changes in anorexia nervosa (AN) as a purging type. On the basis of three clinical cases, a description has been made of the beginning and the possible course of the disease, teeth, oral mucosa, and skin changes resulting from the illness. The research method was based on the analysis of the available literature on AN supplemented by clinical experience of presented cases. On the basis of the interdisciplinary analysis, it was concluded that the appropriate diagnosis and treatment of AN are possible only with the collaboration of many specialists-psychiatrist or pediatric psychiatrist, general practitioner, dermatologist, dentist, and if necessary other medical specialists. In this context, psychotherapy is an integral aspect of treatment. Therefore, early intervention is essential to obtain good results of treatment. AbstractKeywords ► anorexia nervosa ► vomiting ► xerosis ► dental erosion

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Impact of a non‐fluoridated microcrystalline hydroxyapatite dentifrice on enamel caries progression in highly caries‐susceptible orthodontic patients: A randomized, controlled 6‐month trial

Cited by 54 publications

References 20 publications

Ca2+ release and buffering effects of synthetic hydroxyapatite following bacterial acid challenge

Ca2+ release and buffering effects of synthetic hydroxyapatite following bacterial acid challenge

In Vivo Effects of a Hydroxyapatite-Based Oral Care Gel on the Calcium and Phosphorus Levels of Dental Plaque

Anorexia Nervosa with Vomiting Episodes: Dermatological and Oral Complications

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