Impact of Acupuncture on Stress Levels of Professionals Working with Maltreated Children

Oliveira, Christian César Cândido de; Scivoletto, Sandra

doi:10.1136/acupmed-2016-011231

Cited by 3 publications

(2 citation statements)

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“…The first pathway detected by STRING concerns insulin signaling and involves the LIPE and PRKAR1B genes Studies: studies found to assess acupuncture effects on burnout referenced [16][17][18][19][20]. Cohort: total number of individuals and brief description of the cohort.…”

Section: Insulin Signaling Pathway: Lipe (Cg01537765) and Prkar1b (Cg...mentioning

confidence: 99%

“…For example, Guan et al [17] reported that the professional quality of life (ProQOL) scale established before and after acupuncture in 11 resident physicians experiencing a high level of job-related stress showed a significant score improvement posttreatment, with no negative impact of acupuncture. Another study in humans also reported a positive impact of acupuncture treatment on burnout-derived outcomes and concluded that acupuncture therapy could be a useful intervention to reduce burnout and was well accepted [18][19][20]. Of note, more than 100 different clinical trials registered in the United States National Institute of Health database (https://clinicaltrials.gov) are currently recruiting patients to assess acupuncture efficiency.…”

Section: Introductionmentioning

confidence: 99%

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Epigenomic Changes after Acupuncture Treatment in Patients Suffering from Burnout

Petitpierre¹,

Stenz

Paoloni-Giacobino

2021

Complement Med Res

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Introduction: The effects of acupuncture treatment in patients suffering from burnout may imply an epigenetic control mediated by DNA methylation changes. In this observational study, a genome-wide characterization of epigenetic changes in blood DNA, before and after acupuncture treatment, was performed in a cohort of 11 patients suffering from burnout. Methods: Burnout was assessed using the Maslach Burnout Inventory (MBI) and DNA was extracted from blood samples and analyzed by Illumina EPIC BeadChip. Results: Before acupuncture, all patients suffered of emotional exhaustion (EE) (MBI-EE score, 44±6), 81% suffered of depersonalization (DP) (MBI-DP score, 16±6), and 72% of low feelings of personal accomplishment (PA) (MBI-PA score, 29±9). After acupuncture, all MBI dimensions improved significantly (EE, 16±11 [p=1.5*10-4]; DP, 4±5 [p=5.3*10-4]; and PA, 40±6 [p=4.1*10-3]). For each patient, both methylomes obtained before and after acupuncture co-clustered in the multidimensional scaling plot, indicating a high level of similarity. Genes corresponding to the 10 most differentially methylated CpGs showed enrichment in the brain dopaminergic signalling, steroid synthesis and in the insulin sensitivity pathways. Conclusion: Acupuncture treatment was found to be highly effective on all burnout dimensions and the epigenetic targets identified were involved in some major disturbances of this syndrome.

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