Impact of acute exercise on antioxidant enzymes activity and lipid status in blood of patients with hypertension

Abstract

No significantly elevated Ox LDL, GSH-Px and PAI-1 levels were found in hypertensive patients during basal condition in comparison with healthy subjects. Decreased GSH-Px activity was associated with those in acute exercise only in hypertensive patients. It could be an important indicator of deficiency of physiological antioxidative defense mechanism in hypertensive patients during an acute exercise.

Eicosanoid Production following One Bout of Exercise in Middle-Aged African American Pre- and Stage 1 Hypertensives

“…There has been some conflicting evidence in regards to how exercise influences TXA 2 concentrations following exercise. Aerobically trained individuals seem to have an enhanced antioxidant system [29, 31], which could explain the lack of significant alterations in TXA 2 activity at the low exercise intensity. …”

The Impact of Exercise on Redox Equilibrium in Cardiovascular Diseases

“…CVDs are commonly characterized by glucose metabolic syndrome, oxidative stress and inflammation, whilst PA is known to improve redox status, insulin sensitivity and endothelial function [ 100 ]. The effects of PA on oxidant–antioxidant equilibrium can be ambiguous and depend on the duration and intensity of exercise; however, in general, they are positive [ 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 ] ( Table 1 ). Physical exercise of different intensities (usually of moderate or of low intensity, and long term) is already widely recommended as an aid in the prevention and treatment of CVDs.…”

“…A lack of an impact of aerobic exercise on SOD was also proved by Fenty-Stewart et al in the plasma of venous blood in 100 hypertensive patients (50–75 years). However, they observed a positive correlation between SOD activity and 8-iso-PGF2α concentration in urine [ 96 ], whereas, Kostić et al observed a statistically significant decrease in erythrocyte GPx activity after an acute exercise test on the cycloergometer in peripheral blood in 40 hypertensive patients (51.19 ± 8.37 years) [ 97 ]. Yu et al examined dependence between the type and frequency of physical exercise, and redox biomarkers in the plasma of venous blood in persons between 45 and 79 years old with idiopathic arterial hypertension (n = 402), with the use of a control group (n = 1047).…”