Impact of adiposity on immunological parameters

Moulin, Cristiane Martins; Marguti, Ivo; Peron, Jean Pierre; Rizzo, Luiz Vicente; Halpern, Alfredo

doi:10.1590/s0004-27302009000200010

Cited by 50 publications

(40 citation statements)

References 51 publications

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“…Our findings are in line with the results of many previous studies as Moulin et al who showed in his study that obesity is associated with the modulation of immune parameters (33), elevated numbers of circulating immune cells as neutrophil, monocyte, leukocyte and total WBC (34,35), as well as elevated activation levels of certain WBC and suppressed immune cell function (15). Also, several authors have reported a chronic inflammation status in individuals with higher BMI (36-38) which was associated with elevated amounts of white blood cells, neutrophils, and monocytes in the blood of all participants with BMI higher than that of the control group (39).…”

Section: Discussionsupporting

confidence: 94%

Correlation between serum alanine aminotransferase activity and immunologic response and body mass index in obese patients with chronic hepatitis B virus infection

Al-Sharif

2017

Electron J Gen Med

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Background & Objective:Chronic B viral hepatitis is a major health problem worldwide. Several studies have reported that obesity is important risk factors altered immune system response in individuals with no underlying causes of liver disease. This study was to examine the correlation between body mass index, serum alanine aminotransferase activity and immunologic response in obese hepatitis B Saudi patients. Subjects and Methods: One hundred fifty Saudi male patients with hepatitis B viral infection (HBV); their age ranged from 30 to 45 (38.64 ± 7.12) years. Patients were divided in to two equal groups according to their body mass index: Group (A): Included patients with HBV, their body mass index (BMI) was greater than 30 kg/m 2 (the obese group). Group (B): Included patients with HBV, their BMI between 20 and 24 kg/m 2 (the normal-weight group). Results: An elevation of serum alanine aminotransferase (ALT) activity was found to be associated with increased BMI, also we observed an elevation with regard to the normal weight group in the parameters of white blood cells, neutrophils, monocytes, CD3, CD4 and CD8 for group A. CD3, CD4 and CD8 correlated with BMI only as a total amount, as well as with all measured parameters of blood count. Conclusion: Obesity adversely affects the immunological response and rate of disease progression in HBeAg-negative chronic hepatitis B viral infection. Body weight control is important in the management of patients with chronic hepatitis B viral infection.

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Section: Discussionsupporting

confidence: 94%

Correlation between serum alanine aminotransferase activity and immunologic response and body mass index in obese patients with chronic hepatitis B virus infection

Al-Sharif

2017

Electron J Gen Med

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“…The maturation of monocytes into macrophages was found to be lower, and the capacity of polymorphonuclear (PMN) to be bactericidal was found to be reduced in obese individuals [28,29]. Severely obese individuals also have a significant decrease in NK cell activity compared with control individuals after adjustment for age and gender [30]. People with diabetes mellitus are also easily affected by chronic infections.…”

Section: The Effect Of Obesity On H Pylori Infectionmentioning

confidence: 99%

Association between Helicobacter pylori infection and overweight or obesity in a Chinese population

Zhang

Chen

et al. 2015

J Infect Dev Ctries

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Introduction: Recent studies found that Helicobacter pylori (H. pylori) infection plays a role in cardiometabolic disorders. The objective of this study was to assess the association between H. pylori infection and overweight or obesity in a Chinese population. Methodology: A cross-sectional analysis using data from the subjects who underwent a health examination between January 2010 and June 2012 in the department of comprehensive medicine was performed. Diagnosis of H. pylori infection was achieved using the carbon urea breath test (

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“…The biological activities of interleukin-6 contribute to the progression of the atheromatous plaque 24 . In the study of Valezi et al 25 , 20 patients with morbid obesity that underwent bariatric surgery were studied regarding inflammatory markers, indicators of oxidative stress and antioxidant defense.…”

Section: Discussion Discussion Discussion Discussion Discussionmentioning

confidence: 99%

Ultrasound evaluation on carpal tunnel syndrome before and after bariatric surgery

Castro

Skare

Nassif

et al. 2014

Rev. Col. Bras. Cir.

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Objective:To evaluate the prevalence of carpal tunnel syndrome in candidates for bariatric surgery comparing with the non-obese population and verify the effects on it of bariatric treatment. Methods:We studiedthree groups of individuals: 1) patients waiting for bariatric surgery (preoperative); 2) individuals who had already undergone the procedure (postoperative); and 3) control group. We collected demographic and clinical data of carpal tunnel syndrome. The Ultrasound examination was carried out to diagnose the syndrome by measuring the median nerve area. Results:We included 329 individuals (114 in the preoperative group, 90 in the postoperative group and 125 controls). There was a higher prevalence of paresthesias (p=0.0003), clinical tests (p=0.0083) on the preoperative group when compared with controls (p<0.00001). There were lowe levels of paresthesias (p=0.0002) and median nerve area (p=0.04) in postoperative patients but with no significant difference in general. A significant difference was found between the preoperative and postoperative groups (p=0.05) in those who performed non-manual work.Conclusion: There was a higher prevalence of carpal tunnel syndrome in the preoperative group compared with the control one, but no significant difference was observed between the pre and postoperative groups in general. There was difference between pre and postoperative groups for non-manual workers.

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Impact of adiposity on immunological parameters

Cited by 50 publications

References 51 publications

Correlation between serum alanine aminotransferase activity and immunologic response and body mass index in obese patients with chronic hepatitis B virus infection

Correlation between serum alanine aminotransferase activity and immunologic response and body mass index in obese patients with chronic hepatitis B virus infection

Association between Helicobacter pylori infection and overweight or obesity in a Chinese population

Ultrasound evaluation on carpal tunnel syndrome before and after bariatric surgery

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