Impact of age on male fertility

Crosnoe, Lindsey E.; Kim, Edward D.

doi:10.1097/gco.0b013e32836024cb

Cited by 26 publications

(19 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Interestingly, our data suggest that only advanced paternal age is associated with cleft palate, whereas no significant relationship appeared between advanced maternal age at conception and the risk of cleft palate. It is now well established that male reproductive function declines with age [29,30]. Furthermore, a landmark study [31] published in 2012 identified that the diversity in the mutation rate of single nucleotide polymorphism (SNP) in the offspring increased by two mutations per year based on paternal age at conception of children.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Parental Risk Factors for Speech Disability Associated with Cleft Palate in Chinese Children—A National Survey

Yun

Wang

et al. 2016

IJERPH

View full text Add to dashboard Cite

Abstract:Although the prevalence of oral clefts in China is among the highest worldwide, little is known about the prevalence of speech disability associated with cleft palate in Chinese children. The data for this study were collected from the Second China National Sample Survey on Disability, and identification of speech disability associated with cleft palate was based on consensus manuals. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). A weighted number of 112,070 disabled children affected by cleft palate were identified, yielding a prevalence of 3.45 per 10,000 children (95% CI: 3.19-3.71). A history of speech disability in the mother (OR = 20.266, 95% CI 5.788-70.959, p < 0.0001), older paternal child-bearing age (OR = 1.061, 95% CI 1.017-1.108, p = 0.0065, per year increase in age), and lower parental education (maternal: OR = 3.424, 95% CI 1.082-10.837, p = 0.0363; paternal: OR = 2.923, 95% CI 1.245-6.866, p = 0.0138) were strongly associated with risk of speech disability associated with cleft palate in the offspring. Our results showed that maternal speech disability, older paternal child-bearing age, and lower levels of parental education were independent risk factors for speech disability associated with cleft palate for children in China. These findings may have important implications for health disparities and prevention.

show abstract

Section: Discussionmentioning

confidence: 99%

Prevalence and Parental Risk Factors for Speech Disability Associated with Cleft Palate in Chinese Children—A National Survey

Yun

Wang

et al. 2016

IJERPH

View full text Add to dashboard Cite

show abstract

“…Previous studies observed the following generalities: a) Increased age is associated with a higher rate of de novo mutations and other genomic abnormalities in male germ cells (Crosnoe and Kim, 2013; Singh et al, 2003); b) Such abnormalities are more common in schizophrenia than in normal controls (Walsh et al, 2008); and, c) Older paternal age is associated with greater risk of schizophrenia (Malaspina, 2001). A model that explains how a) and b) could imply c) is that de novo mutations and other genomic abnormalities are more frequently among the contributing factors leading to schizophrenia when the proband has an older father versus a younger one (Kong et al, 2012).…”

Section: Introductionmentioning

confidence: 98%

Paternal age of schizophrenia probands and endophenotypic differences from unaffected siblings

Schmeidler

Lazzeroni

Swerdlow

et al. 2014

Psychiatry Research

View full text Add to dashboard Cite

Objective To evaluate the discrepancy of endophenotypic performance between probands with schizophrenia and unaffected siblings by paternal age at proband birth, a possible marker for de novo mutations. Methods Pairs of schizophrenia probands and unaffected siblings (N=220 pairs) were evaluated on 11 neuropsychological or neurophysiological endophenotypes previously identified as heritable. For each endophenotype, the sibling-minus-proband differences were transformed to standardized scores. Then for each pair, the average discrepancy was calculated from its standardized scores. We tested the hypothesis that the discrepancy is associated with paternal age, controlling for the number of endophenotypes shared between proband and his or her sibling, and proband age, which were both associated with paternal age. Results The non-significant association between the discrepancy and paternal age was in the opposite direction from the hypothesis. Of the 11 endophenotypes only sensori-motor dexterity was significant, but in the opposite direction. Eight other endophenotypes were also in the opposite direction, but not significant. Discussion The results did not support the hypothesized association of increased differences between sibling/proband pairs with greater paternal age. A possible explanation is that the identification of heritable endophenotypes was based on samples for which schizophrenia was attributable to inherited rather than de novo/non-inherited causes.

show abstract

“…However, studies analyzing male age have demonstrated declines in structural and functional parameters and established the age of 40 as a cutoff or turning point ( Guérin et al ., 2005 ; Evenson & Wixon, 2006 ; Belloc et al ., 2008 ). Additionally, studies have indicated that advanced paternal age increases the risk of miscarriage ( Slama et al ., 2005 ; Kleinhaus et al , 2006 ) and the potential of certain diseases occurring in the offspring, such as genetic abnormalities, pediatric cancer, and several neuropsychiatric disorders ( Hemminki & Kyyrönen, 1999 ; Wyrobek et al ., 2006 ; O’Roak et al ., 2012 ; Crosnoe & Kim, 2013 ; Paul & Robaire, 2013 ). Advanced male age has also been correlated with infant mortality ( Urhoj et al ., 2014 ).…”

Section: Introductionmentioning

confidence: 99%

The effects of male age on sperm DNA damage: an evaluation of 2,178 semen samples

Comar¹,

Ricci²,

Dieamant³

et al. 2018

JBRA Assisted Reproduction

View full text Add to dashboard Cite

ObjectiveThis study aimed to evaluate the effects of male age on sperm DNA damage.MethodsThis cross-sectional study included semen samples collected from 2,178 men seen at an infertility clinic. For DNA integrity analysis, the proportions of spermatozoa showing DNA fragmentation (TUNEL assay), abnormal chromatin packaging/underprotamination (chromomycin A3), abnormal mitochondrial membrane potential (MMP/MitoTracker Green), and apoptosis (annexin V) were recorded. For group comparisons, enrolled subjects were divided into three groups based on their ages: ≤35 years; 36-44 years; and ≥45 years. The associations between age and sperm parameters were assessed using Spearman's rank correlation coefficient.ResultsAlthough aging did not affect sperm apoptosis (p>.05), sperm DNA fragmentation and MMP deteriorated significantly with age (p<.05). Chromatin packaging/protamination improved significantly with age (p<.05).ConclusionSperm DNA fragmentation worsened with age and was apparently associated with mitochondrial damage. The age-related increase in sperm DNA damage suggests that delaying childbearing, not only in women but also in men, might jeopardize a couple’s reproductive capacity. The increase seen in chromatin packaging might represent a protective feature for DNA. However, additional studies must be performed to confirm the results concerning chromatin packaging/protamination.

show abstract

Impact of age on male fertility

Abstract: Aging has an impact on male fertility potential, as well as potential genetic effects for the offspring.

Cited by 26 publications

References 30 publications

Prevalence and Parental Risk Factors for Speech Disability Associated with Cleft Palate in Chinese Children—A National Survey

Prevalence and Parental Risk Factors for Speech Disability Associated with Cleft Palate in Chinese Children—A National Survey

Paternal age of schizophrenia probands and endophenotypic differences from unaffected siblings

The effects of male age on sperm DNA damage: an evaluation of 2,178 semen samples

Contact Info

Product

Resources

About