Impact of aging on substrate metabolism by the human heart

Abstract

With aging, humans exhibit a decline in MFAU and MFAO. Although absolute rates of MGU do not increase, by virtue of the decline in MFAU there is likely an increase in relative contribution of MGU to substrate metabolism. The clinical significance of this metabolic switch awaits further study.

Abnormal Myocardial Energy-Production State in Mitochondrial Cardiomyopathy and Acute Response to L-Arginine Infusion - C-11 Acetate Kinetics Revealed by Positron Emission Tomography -

“…Previous reports suggest that the increase in myocardial oxygen consumption (kmono) parallels that of the DP as age increases. 27 Therefore, it seems plausible to consider that a comparison with older age-matched control would indicate the decline in the baseline kmono values of the MELAS patients more clearly.…”

Age Dependency of Myocardial Triglyceride Content: A 3T High-Field 1H-MR Spectroscopy Study

“…3 Das Bland-Altman-Diagramm zeigt die gute Reproduzierbarkeit der wiederholten spektroskopischen Einzelmessungen. Der Korrelationskoeffizient zwischen den einzelnen Messungen betrug r = 0,965; p < 0,001. acid utilization and oxidation with increasing age in healthy humans [20]. Furthermore, an imbalance between tissue uptake and disposal has been demonstrated in the skeletal muscle of elder populations without health issues compared to younger subjects.…”

PET Measurements of Myocardial Glucose Metabolism with 1-11C-Glucose and Kinetic Modeling

“…Pert urbations in myocardial glucose metabolism occur in various diseases and states (1)(2)(3)(4)(5)(6)(7)(8)(9)(10). Thus, accurate measurements of myocardial glucose metabolism are necessary to better understand the physiology or pathophysiology of these processes and to evaluate novel therapies designed to ameliorate detrimental effects on cardiac function.…”