Impact of alcohol use on thyroid function

Balhara, Yatan Pal Singh; Deb, Koushik Sinha

doi:10.4103/2230-8210.113724

Cited by 98 publications

(36 citation statements)

References 61 publications

(80 reference statements)

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“…Interestingly, in our cohort, fT4 levels could be associated with alcohol and Her2 positivity. Alcohol has been reported to cause direct suppression of thyroid function, which is in line with our findings [31]. However, the correlation of Her2 positivity and fT4 has not been described yet.…”

Section: Discussionsupporting

confidence: 92%

Elevated Free Thyroxine Levels Are Associated with Poorer Overall Survival in Patients with Gastroesophageal Cancer: A Retrospective Single Center Analysis

et al. 2019

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As endocrinological parameters such as thyroid hormones modulate proliferative, metabolic, and angiogenic pathways, it is surmised that their levels can be associated with cancer development and progression. Most patients with gastroesophageal cancer are diagnosed very late and have a poor prognosis, yet the association with endocrinological parameters has not been addressed so far. The aim of this study was to correlate hormones with the outcome, so new prognostic and potentially therapeutic markers can be defined. We analyzed clinical and endocrinological parameters including history of thyroid disorders and laboratory analyses of thyroid hormones and correlated these with the overall survival in a large European cohort of patients with inoperable locally advanced or metastatic gastroesophageal cancer treated between 2002 and 2018 at the Vienna General Hospital, Austria. In total, the survival outcome of 258 patients was evaluated. Higher levels of fT4 (p = 0.041, HR = 2.202) and lower levels of T3 (p = 0,003, HR = 0,141) were associated with significantly shorter survival. However, the overall survival of patients with known thyroid disorders did not differ significantly from euthyroid patients (euthyroid, 283 days; hyperthyroid, 354 days; hypothyroid, 284 days; p = 0.472). Elevated fT4 levels are associated with poorer overall survival of patients with gastroesophageal cancer in advanced stages. Since data on the correlation of endocrinological parameters and gastroesophageal cancer are scarce, this analysis is an important impulse for further studies concerning the impact of thyroxine on patients with cancer of the upper GI tract. Keywords Gastric. Esophagus. Gastroesophageal. Hyperthyroidism. Thyroxine Abbreviations BMI Body mass index fT3 Free triiodothyronine fT4 Free thyroxine GI Gastrointestinal NTIS Nonthyroidal illness syndrome

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Section: Discussionsupporting

confidence: 92%

Elevated Free Thyroxine Levels Are Associated with Poorer Overall Survival in Patients with Gastroesophageal Cancer: A Retrospective Single Center Analysis

et al. 2019

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“…Endocrinol in 1980 that also shows a markedly reduced T3 level in patients with alcoholic cirrhosis. 18 In this study T4 levels were found within normal range in 65 patients (85.5 percent) whereas 11 patients had a low serum T4 level. So, normal level of T4 was found in significant majority cases.…”

Section: Resultssupporting

confidence: 42%

Decompensated Cirrhosis; Thyroid Hormone Levels in Patients

Mobin

Haroon

Shaikh

et al. 2016

TPMJ

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“…In addition, maternal alcohol use, smoking and substance use during pregnancy were not universally included across the studies, which may have confounded the associations of interest. These factors have been found to increase the risk of thyroid hormone imbalance during pregnancy, consequently affecting the pregnancy outcome (58,59,60,61). Evidence also suggests that exposure to maternal tobacco, cannabis and alcohol use during pregnancy may lead to detrimental neurologic effects on the offspring (62).…”

Section: Discussionmentioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: Maternal thyroid dysfunction during pregnancy and behavioural and psychiatric disorders of children: a systematic review

Fetene

Betts

Alati

2017

European Journal of Endocrinology

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Background: Maternal thyroid dysfunction during pregnancy may lead to persistent neurodevelopmental disorders in the offspring appearing in later life. This study aimed to review the available evidence concerning the relationship between maternal thyroid status during pregnancy and offspring behavioural and psychiatric disorders. Methods: Systematic electronic database searches were conducted using PubMed, Embase, PsycNET, Scopus, Google Scholar and Cochrane library. Studies including gestational thyroid dysfunction as the exposure and offspring behavioural and psychiatric disorders as the outcome were included. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline was followed and, after thorough screening by two independent reviewers, 13 articles remained eligible for inclusion in this study. Results: Indicators of maternal thyroid dysfunction, including low and high thyroid hormone level and autoimmune thyroiditis, during early pregnancy, were found to be associated with several offspring behavioural and psychiatric disorders such as attention deficit hyperactivity disorder (ADHD), autism, pervasive developmental problems, externalising behaviour, in addition to epilepsy and seizure. The majority of associations were found with low maternal thyroid hormone level. Conclusion: Maternal thyroid function during pregnancy, particularly hypothyroidism, is associated with behavioural and psychiatric disorders in children. Further studies are needed with a capacity to adjust for a fuller range of confounding factors.

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Impact of alcohol use on thyroid function

Cited by 98 publications

References 61 publications

Elevated Free Thyroxine Levels Are Associated with Poorer Overall Survival in Patients with Gastroesophageal Cancer: A Retrospective Single Center Analysis

Elevated Free Thyroxine Levels Are Associated with Poorer Overall Survival in Patients with Gastroesophageal Cancer: A Retrospective Single Center Analysis

Decompensated Cirrhosis; Thyroid Hormone Levels in Patients

MECHANISMS IN ENDOCRINOLOGY: Maternal thyroid dysfunction during pregnancy and behavioural and psychiatric disorders of children: a systematic review

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