Impact of an intense stress on ethanol consumption in female rats characterized by their pre-stress preference: Modulation by prenatal stress

Darnaudéry, Muriel; Louvart, Hélène; Defrance, Lydie; Léonhardt, Marion; Morley‐Fletcher, Sara; Gruber, Susanne; Galietta, Gabriella; Mathé, Aleksander A.; Maccari, Stefania

doi:10.1016/j.brainres.2006.11.005

Cited by 30 publications

(25 citation statements)

References 44 publications

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“…In contrast, there have been several studies that have utilized inescapable footshock and subsequently found stress-associated decreases in alcohol intake (Bond 1978; Champagne and Kirouac 1987; Darnaudery et al 2007). For example, when footshock was administered for 6 days to male Sprague–Dawley rats, alcohol intake significantly decreased, returning to prestress levels after stress exposure was terminated (Bond 1978).…”

Section: Acute/sub-chronic Stress Exposure During Alcohol Accessmentioning

confidence: 97%

“…For instance, studies in which animals had little or no prior opportunity to drink alcohol have reported decreased (e.g., Bond 1978), increased (e.g., Anisman and Waller 1974), or unchanged (e.g., Brunell and Spear 2005; Myers and Holman 1967; Von Wright et al 1971) alcohol intake following footshock experience. Likewise, studies in which animals were given at least 2 weeks access to alcohol prior to stress administration have reported decreased (Darnaudery et al 2007), increased (Mills et al 1977; Vengeliene et al 2003), or unaltered (Fidler and LoLordo 1996; Ng Cheong Ton et al 1983) alcohol consumption as a function of footshock exposure.…”

Section: Acute/sub-chronic Stress Exposure During Alcohol Accessmentioning

confidence: 99%

“…While only a few studies included analysis of female subjects, results from those studies were similarly mixed. Specifically, footshock stress in females was reported to increase (Fullgrabe et al 2007), decrease (Darnaudery et al 2007), or not significantly alter (Chester et al 2008; Cox and Stainbrook 1977; Powell et al 1966) alcohol consumption.…”

Section: Acute/sub-chronic Stress Exposure During Alcohol Accessmentioning

confidence: 99%

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Effects of stress on alcohol drinking: a review of animal studies

López²,

2011

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Rationale While stress is often proposed to play a significant role in influencing alcohol consumption, the relationship between stress and alcohol is complex and poorly understood. Over several decades, stress effects on alcohol drinking have been studied using a variety of animal models and experimental procedures, yet this large body of literature has generally produced equivocal results. Objectives This paper reviews results from animal studies in which alcohol consumption is evaluated under conditions of acute/sub-chronic stress exposure or models of chronic stress exposure. Evidence also is presented indicating that chronic intermittent alcohol exposure serves as a stressor that consequently influences drinking. Results The effects of various acute/sub-chronic stress procedures on alcohol consumption have generally been mixed, but most study outcomes suggest either no effect or decreased alcohol consumption. In contrast, most studies indicate that chronic stress, especially when administered early in development, results in elevated drinking later in adulthood. Chronic alcohol exposure constitutes a potent stressor itself, and models of chronic intermittent alcohol exposure reliably produce escalation of voluntary alcohol consumption. Conclusions A complex and dynamic interplay among a wide array of genetic, biological, and environmental factors govern stress responses, regulation of alcohol drinking, and the circumstances in which stress modulates alcohol consumption. Suggestions for future directions and new approaches are presented that may aid in developing more sensitive and valid animal models that not only better mimic the clinical situation, but also provide greater understanding of mechanisms that underlie the complexity of stress effects on alcohol drinking.

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Section: Acute/sub-chronic Stress Exposure During Alcohol Accessmentioning

confidence: 97%

Section: Acute/sub-chronic Stress Exposure During Alcohol Accessmentioning

confidence: 99%

Section: Acute/sub-chronic Stress Exposure During Alcohol Accessmentioning

confidence: 99%

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Effects of stress on alcohol drinking: a review of animal studies

López²,

2011

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“…Rodent strains with lower initial alcohol preference may • show a stress-related increase in alcohol intake, whereas those with higher alcohol preference show either no change or a decrease in intake (Chester et al 2004;Darnaudery et al 2007;Lowery et al 2008;Rockman and Glavin 1986;; but see BoyceRustay et al 2008). These divergent results could refl ect strain differences in basal stress reactivity rather than alcohol preference per se.…”

Section: Mixed Results Of Stressors In Rodent Models Of Self-administmentioning

confidence: 94%

Translational Models of Interactions Between Stress and Alcohol Consumption: Strengths and Limitations

Hopf¹,

Sparta²,

Bonci³

2011

ILAR Journal

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Much has been written about the interaction of stressors (physical, social, and psychological) and alcohol addiction based on studies in humans and preclinical models. We begin by considering the significance and complexity of alcoholism and the options for effectively modeling it in animals, particularly rodents. We then focus on the following aspects of stress-alcohol interactions: (1) compulsive alcohol consumption, characterized by continued intake despite the presence of stressful or aversive consequences; (2) the possible relationship between acute stress and increased alcohol intake; (3) an apparent cross sensitization of stress and alcohol exposure, which increases both future reactivity to stress and the risk of developing alcohol addiction; and (4) efforts to target stress in therapeutic interventions for alcoholism. We also describe possible neuroadaptations and genetic factors that may interact with stress to increase susceptibility to alcoholism. Throughout, we describe the challenges and inconsistencies inherent in both human and animal studies of alcoholism, its etiology, and its impacts. We believe the relationship between preclinical and human studies is of paramount importance to understand addiction-related behavior in humans and to direct, improve, and expand animal models. It is our hope that a full understanding of the mechanistic bases of pathological alcohol intake will have translational benefits for the development of behavioral and pharmacological therapies.

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“…However, these effects are dependent on the protocol used for maternal separation (Jaworski et al 2005). To date, it is unknown whether the prenatal period constitutes an equally sensitive window (Darnaudery et al 2007;DeTurck and Pohorecky 1987;Weinberg 1987).…”

Section: Introductionmentioning

confidence: 98%