Impact of antioxidant supplementation on chemotherapeutic efficacy: A systematic review of the evidence from randomized controlled trials

Block, Keith I.; Koch, Amanda; Mead, Mark N.; Tothy, Peter K.; Newman, Robert A.; Gyllenhaal, Charlotte

doi:10.1016/j.ctrv.2007.01.005

Cited by 202 publications

(141 citation statements)

References 41 publications

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“…33 In comparison with palifermin, NAC is relatively inexpensive and has no considerable interactions with antineoplastic drugs. [34][35][36][37] In our study, the overall duration of OM was also significantly shorter in the NAC group whereas in Jahangard-Rafsanjani et al 9 study, only the mean duration of severe OM (grade 3-4) was significantly lower in the intervention group (selenium). However, none of the agents could alter time to onset of OM.…”

Section: Discussionmentioning

confidence: 70%

N-acetyl cysteine for prevention of oral mucositis in hematopoietic SCT: a double-blind, randomized, placebo-controlled trial

Moslehi

Taghizadeh-Ghehi

Gholami

et al. 2014

Bone Marrow Transplant

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Oral mucositis (OM) is a complication of high-dose chemotherapy (HDC) which is frequently observed in hematopoietic SCT settings. Antioxidant agents have been proposed to prevent OM and therefore N-acetyl cysteine (NAC) could have an important role. In the present study, we conducted a double-blind, randomized, placebo-controlled study to evaluate the NAC effect on OM incidence and severity, and also glutathione peroxidase-1 activity. Leukemia patients undergoing allogeneic hematopoietic SCT preceded by HDC were recruited into the study and received either NAC (100 mg/kg/day) (n = 38) or placebo (n = 42) from the starting day of HDC until day +15 after transplantation. OM was evaluated daily for 21 days after transplantation according to World Health Organization oral toxicity scale. The incidence of severe OM (grades 3-4) was significantly lower in the NAC group (23.7% vs 45.3%, P = 0.04). Moreover, the mean duration of OM was significantly shorter in the intervention group (6.24(2.96) vs 8.12(3.97) days, P = 0.02). The glutathione peroxidase-1 activity was also significantly higher in the NAC group seven days after transplantation (3.38(2.19) vs 2.41(1.70) ng/mL, P = 0.003). It is concluded that parenteral NAC is effective in reducing the incidence of severe cases and the total duration of OM.

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Section: Discussionmentioning

confidence: 70%

N-acetyl cysteine for prevention of oral mucositis in hematopoietic SCT: a double-blind, randomized, placebo-controlled trial

Moslehi

Taghizadeh-Ghehi

Gholami

et al. 2014

Bone Marrow Transplant

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“…Alternatively, there remains considerable controversy as to whether antioxidants may also reduce the tumoricidal effects of chemotherapy that act as strong oxidants. 5,6 In this regard, Weiss et al 36 have recently reported that NAC administered for 10 days after allo-SCT to BALB/c mice led to a mild reduction in graft-versus-leukemia.…”

Section: Discussionmentioning

confidence: 99%

“…Some have antitumor activity and others may enhance the effect of other anticancer treatments. 3,5,6 Despite a great number of reported studies, an excellent review by Malmberg 5 and a meta-analysis by Block et al 6 point out that their ability to enhance tumor killing is variable and that the loss of host immune response to tumor antigens is a potential drawback. In this regard, there are very few agents that have proven clinically effective in reducing normal tissue injury induced by IR and cytoreductive chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

“…To offset some of the undesirable effects, dietary supplements and antioxidants have been increasingly utilized. [1][2][3][4][5][6] They are presumed to reduce the toxic effects of the therapy, reduce oxidative stress and enhance the host immune response to some cancers. Some have antitumor activity and others may enhance the effect of other anticancer treatments.…”

Section: Introductionmentioning

confidence: 99%

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Amifostine prior to lethal irradiation prevents allogeneic bone marrow engraftment in mice

Thompson

Asmis

Chu

et al. 2008

Bone Marrow Transplant

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“…The present study suggests that, Raphnus sativus partial purified protein with SOD-like activity may be one of the treatment strategies. Ben Salah-Abbès, reported that, the extract of radishcontains many antioxidant compounds that protect against the toxicity resulting from mycotoxin (Zearalenone) [36] [37].…”

Section: Discussionmentioning

confidence: 99%

Suppression Effect of Superoxide Dismutase (SOD)-Like Activity Protein Partially Purified from <i>Raphnus sativus</i> Leaves against Liver Metastasis in Mice Intraperitoneally Infected with Ehrlich Ascites Carcinoma Cell

Toson¹,

Almutairi²,

Elfalal³

et al. 2016

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Liver metastasis is a normal result in Ehrlich Ascites Carcinoma Cell (EAC) infected mice. A partially purified protein with Superoxide Dismutase (SOD)-like activity extracted from leaves of Raphnus sativus was tested for its ability to down regulate liver metastasis of Ehrlich Ascites Carcinoma Cell (EAC) intraperitoneally implanted in albino mice. Sixty albino mice were divided equally into 4 groups. Group I mice (G1 control) were treated with physiologic saline solution for 7 days. Group 2 mice (G2) were injected with the partially purified protein. Group 3 mice (G3) were intraperitoneally inoculated with EAC cells and treated with the partially purified protein. Group 4 mice (G4) were inoculated EAC cells and treated with physiologic saline solution. The results showed a disturbance in liver functions. This disturbance was observed as a reduction in the values of serum albumin, hemoglobin, total counts of erythrocytes and platelets, total lipids in liver tissues, erythrocytes SOD activity, serum glucose, reduced glutathione (GSH) and the trace elements (Fe, Mn, Zn, and Cu) contents in liver and spleen tissues as well as the elevation of serum transaminases activities, the levels of malondialdehyde in blood, DNA and RNA of liver tissues in the infected mice (G4). On the other hand, in G3, after treatment with the partial purified protein all these parameters restored their normal values and became near from the normal group (GI). Moreover, the protein showed no toxicity towards the mice as shown in G2. It could be concluded 322that a partially purified protein with Superoxide Dismutase (SOD)-like activity extracted from leaves of Raphnus sativus as a nature source has a promised future in controlling liver metastasis.

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Impact of antioxidant supplementation on chemotherapeutic efficacy: A systematic review of the evidence from randomized controlled trials

Cited by 202 publications

References 41 publications

N-acetyl cysteine for prevention of oral mucositis in hematopoietic SCT: a double-blind, randomized, placebo-controlled trial

N-acetyl cysteine for prevention of oral mucositis in hematopoietic SCT: a double-blind, randomized, placebo-controlled trial

Amifostine prior to lethal irradiation prevents allogeneic bone marrow engraftment in mice

Suppression Effect of Superoxide Dismutase (SOD)-Like Activity Protein Partially Purified from <i>Raphnus sativus</i> Leaves against Liver Metastasis in Mice Intraperitoneally Infected with Ehrlich Ascites Carcinoma Cell

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Impact of antioxidant supplementation on chemotherapeutic efficacy: A systematic review of the evidence from randomized controlled trials

Cited by 202 publications

References 41 publications

N-acetyl cysteine for prevention of oral mucositis in hematopoietic SCT: a double-blind, randomized, placebo-controlled trial

N-acetyl cysteine for prevention of oral mucositis in hematopoietic SCT: a double-blind, randomized, placebo-controlled trial

Amifostine prior to lethal irradiation prevents allogeneic bone marrow engraftment in mice

Suppression Effect of Superoxide Dismutase (SOD)-Like Activity Protein Partially Purified from &lt;i&gt;Raphnus sativus&lt;/i&gt; Leaves against Liver Metastasis in Mice Intraperitoneally Infected with Ehrlich Ascites Carcinoma Cell

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Suppression Effect of Superoxide Dismutase (SOD)-Like Activity Protein Partially Purified from <i>Raphnus sativus</i> Leaves against Liver Metastasis in Mice Intraperitoneally Infected with Ehrlich Ascites Carcinoma Cell