Impact of Arrhythmias on Hospitalizations in Patients With Cardiac Amyloidosis

Thakkar, Samarthkumar; Patel, Harsh; Chowdhury, Medhat; Patel, Kirtenkumar; Kumar, Ashish; Arora, Shilpkumar; Zahid, Salman; Goel, Mishita; Barssoum, Kirolos; Jain, Vardhmaan; AbouEzzeddine, Omar F.; DeSimone, Christopher V.; Baibhav, Bipul; Rao, Mohan; Deshmukh, Abhishek

doi:10.1016/j.amjcard.2020.12.024

Cited by 25 publications

(16 citation statements)

References 23 publications

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“…The NIS is an administrative database inclusive of all the insured and uninsured hospitalized patients in the United States generated by the Healthcare Cost and Utilization Project (HCUP) sponsored by the Agency for Healthcare Research and Quality (AHRQ) from the 46 participating US states. 8 It incorporates a stratified sample of 20% nonfederal US community hospitals. NIS includes all patients covered by Medicare, Medicaid, and private payers, as well as those who are uninsured.…”

Section: Methodsmentioning

confidence: 99%

Arrhythmias in patients with in-hospital alcohol withdrawal are associated with increased mortality: Insights from 1.5 million hospitalizations for alcohol withdrawal syndrome

et al. 2021

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Section: Methodsmentioning

confidence: 99%

Arrhythmias in patients with in-hospital alcohol withdrawal are associated with increased mortality: Insights from 1.5 million hospitalizations for alcohol withdrawal syndrome

et al. 2021

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Section: Cardiac Amyloidosis and Arrhythmiasmentioning

confidence: 99%

“…Among arrhythmias in patients with amyloidosis, AF and ventricular arrhythmias are the most frequent, and they may lead to an increase in both hospital mortality rates and length of stay [ 5 , 6 ]. In fact, ventricular arrhythmias are associated with poor prognosis, especially in AL cardiac amyloidosis [ 5 , 6 ]. Sudden cardiac death (SCD) is another significant cause of increased mortality with poor prognosis and a low 5-year survival in these patients [ 5 , 6 ].…”

Section: Cardiac Amyloidosis and Arrhythmiasmentioning

confidence: 99%

Arrhythmias in Patients with Cardiac Amyloidosis: A Comprehensive Review on Clinical Management and Devices

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Kourek

Papamichail

et al. 2023

JCDD

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Cardiac amyloidosis (CA) is a rare but potentially life-threatening disease in which misfolded proteins accumulate in the cardiac wall tissue. Heart rhythm disorders in CA, including supraventricular arrhythmias, conduction system disturbances, or ventricular arrhythmias, play a major role in CA morbidity and mortality, and thus require supplementary management. Among them, AF is the most frequent arrhythmia during CA hospitalizations and is associated with significantly higher mortality, while ventricular arrhythmias are also common and are usually associated with poor prognosis. Early diagnosis of potential arrythmias could be performed through ECG, Holter monitoring, and/or electrophysiology study. Clinical management of these patients is quite significant, and it usually includes initiation of amiodarone and/or digoxin in patients with AF, potential electrical cardioversion, or ablation in specific patients with indication, as well as initiation of anticoagulants in all patients, independent of AF and CHADS-VASc score, for potential intracardiac thrombus. Moreover, identification of patients with conduction disorders that could benefit from prophylactic pacemaker implantation and/or CRT as well as identification of patients with life-threatening ventricular arrythmias that could benefit from ICD could both increase the survival rates of these patients and improve their quality of life.

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“…In a cohort of 5585 patients hospitalized for CA, 2020 (36%) had concurrent arrhythmias, and ventricular tachycardia was the second most common arrhythmia identified (14.9%), after AF (72.2%). All-cause mortality and HF were significantly higher in patients with CA hospitalized with concurrent arrhythmias compared to those without [ 76 ].…”

Section: Ventricular Arrhythmiasmentioning

confidence: 99%

Arrhythmic Burden in Cardiac Amyloidosis: What We Know and What We Do Not

et al. 2022

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Cardiac amyloidosis (CA), caused by the deposition of insoluble amyloid fibrils, impairs different cardiac structures, altering not only left ventricle (LV) systo-diastolic function but also atrial function and the conduction system. The consequences of the involvement of the cardiac electrical system deserve more attention, as well as the study of the underlying molecular mechanisms. This is an issue of considerable interest, given the conflicting data on the effectiveness of conventional antiarrhythmic strategies. Therefore, this review aims at summarizing the arrhythmic burden related to CA and the available evidence on antiarrhythmic treatment in this population.

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Impact of Arrhythmias on Hospitalizations in Patients With Cardiac Amyloidosis

Cited by 25 publications

References 23 publications

Arrhythmias in patients with in-hospital alcohol withdrawal are associated with increased mortality: Insights from 1.5 million hospitalizations for alcohol withdrawal syndrome

Arrhythmias in patients with in-hospital alcohol withdrawal are associated with increased mortality: Insights from 1.5 million hospitalizations for alcohol withdrawal syndrome

Arrhythmias in Patients with Cardiac Amyloidosis: A Comprehensive Review on Clinical Management and Devices

Arrhythmic Burden in Cardiac Amyloidosis: What We Know and What We Do Not

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