Impact of azelastine nasal spray on symptoms and quality of life compared with cetirizine oral tablets in patients with seasonal allergic rhinitis

The Clinical Use of Cetirizine in the Treatment of Allergic Rhinitis

“…Several well-controlled trials have compared the efficacy of cetirizine with placebo and/or other H 1 antihistamines in adults and children with SAR and PAR/PER [43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80]. The majority of these trials have been conducted as double-blind, randomized, placebo-controlled, parallel-group studies in large groups of patients recruited from a single or multiple centres.…”

“…The efficacy of therapeutic doses of cetirizine has been compared in several studies with that of therapeutic doses of other commonly employed and newer preparations of SGAHs in adolescent/adult patients with SAR [55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72] and adolescent/adult and paediatric patients with PAR/PER [73,74,75,76,77,78,79,80]. The majority of these studies have compared the effects of the various antihistamines directly with that of cetirizine and/or placebo on the reduction of symptom severity scores, using different composites of the individual symptom scores as the main efficacy measure.…”

“…In contrast, other studies have not been able to demonstrate any significant differences between fexofenadine 120 mg or fexofenadine 180 mg and cetirizine 10 mg in the treatment of AR symptoms in patients exposed to pollen under experimental [64] or natural seasonal [65,66] conditions, although all active treatments were significantly more effective than placebo. Similarly, several studies investigating the less commonly employed or newer preparations of H 1 antihistamines in the treatment of symptoms in sensitized and symptomatic SAR patients during the grass/tree pollen season have not been able to show significant differences between therapeutic doses of cetirizine and mizolastine [67], emedastine [68], rupatadine [69], bilastine [70] or azelastine [71], although all active treatments were significantly effective in reducing specific total symptom severity scores from baseline or when compared with placebo. Azelastine has been administered as a nasal spray formulation and has produced conflicting data in two large multicentre comparative trials in the USA [71,72].…”

Azelastine HCl: A Review of the Old and New Formulations

“…Furthermore, the rhinitis quality of life questionnaire scores were improved for subjects on azelastine (P  0.05) compared to ceterizine. 33,38,39 Non-allergic rhinitis studies Leiberman et al conducted a large open label study consisting of 4,364 patients with SAR and VMR enrolled over two allergy seasons. Patients were treated with azelastine two sprays b.i.d.…”

Allergic Rhinitis and Quality of Life in Patients with Bronchial Asthma

“…При невозможности достичь контроля болез-ни, несмотря на использование стандартизирован-ной терапии, констатируется тяжёлое хроническое заболевание верхних дыхательных путей (severe chronic upper airway disease, SCUAD). Для оценки здоровья и КЖ пациентов с БА и АР апробирован опросник RAPP (Rhinitis Asthma Patient Perspective), для изучения вклада АР в снижение КЖ паци-ентов с БА используется также международный общий опросник SF-36 [10,12]. В своем исследова-нии O. Aydemir с соавторами [8] обнаружили сни-жение социальных функций и общего психического здоровья у больных с AR, и объясняют это ощуще-ниями стыдливости, тревожностью, сложностях при общении у пациентов.…”