Impact of BDNF Val66Met polymorphism on olfactory functions of female concussed athletes

Larson-Dupuis, Camille; Chamard, Émilie; Falardeau, Viviane; Frasnelli, Johannes; Beaulieu, Christelle; Poirier, Judes; Carrier, Julie; Lassonde, Maryse; Théoret, Hugo; Bacon, Benoît A.; Beaumont, Louis De

doi:10.3109/02699052.2015.1016452

Cited by 12 publications

(10 citation statements)

References 61 publications

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“…It has been suggested before that sports players may be at an increased risk of olfactory impairment especially in contact sports following concussions [1,18]. Here we report that only the participant with a previous severe concussion performed signi icantly worse than controls.…”

Section: Discussionsupporting

confidence: 42%

Olfactory Dysfunction in Sports Players following Moderate and Severe Head Injury: A Possible Cut-off from Normality to Pathology

GM¹

2016

J Sports Med Ther

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Concussion occurs with some frequency in a variety of sports. Any trauma to the brain can also result in temporary or chronic olfactory dysfunction. The relationship between sports concussion and olfactory dysfunction is not well studied, nor do we know whether only more severe injuries result in smell impairments. Three sports players who had previously experienced either a moderate or severe concussion were compared to matched controls. Only the player with a previous severe concussion had a current olfactory impairment. We tentatively suggest that the distinction between moderate and severe concussion may represent a possible cut-off between the presence and absence of olfactory impairment in sports players.

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Section: Discussionsupporting

confidence: 42%

Olfactory Dysfunction in Sports Players following Moderate and Severe Head Injury: A Possible Cut-off from Normality to Pathology

GM¹

2016

J Sports Med Ther

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“…The influence of the Val66Met SNP in mild TBI depends on gender and the post-injury time point. Female concussed athletes carrying a Met allele performed significantly better on assessments of olfactory function than their Val/Val counterparts [56]. Participants in this study were assessed an average of 27 months after their concussion.…”

Section: Val66met In Tbimentioning

confidence: 99%

The Influence of the Val66Met Polymorphism of Brain-Derived Neurotrophic Factor on Neurological Function after Traumatic Brain Injury

Finan

Udani

Patel

et al. 2018

JAD

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Functional outcomes after traumatic brain injury (TBI) vary widely across patients with apparently similar injuries. This variability hinders prognosis, therapy, and clinical innovation. Recently, single nucleotide polymorphism (SNPs) that influence outcome after TBI have been identified. These discoveries create opportunities to personalize therapy and stratify clinical trials. Both of these changes would propel clinical innovation in the field. This review focuses on one of most well-characterized of these SNPs, the Val66Met SNP in the brain-derived neurotrophic factor (BDNF) gene. This SNP influences neurological function in healthy subjects as well as TBI patients and patients with similar acute insults to the central nervous system. A host of other patient-specific factors including ethnicity, age, gender, injury severity, and post-injury time point modulate this influence. These interactions confound efforts to define a simple relationship between this SNP and TBI outcomes. The opportunities and challenges associated with personalizing TBI therapy around this SNP and other similar SNPs are discussed in light of these results.

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“…Participants were asked to rate the 19 symptoms on a scale from 0 (no symptom) to 6 (severe symptom), for a maximum score of 114. At the time of testing, concussed athletes were asymptomatic (symptom threshold for exclusion was fixed at 25) (Larson- Dupuis et al, 2015) reporting few, if any symptoms on the PCSS (mean of 5.18 ± 7.51).…”

Section: Concussion History Form and Post-concussion Symptoms Scalementioning

confidence: 99%

Sex-Related Differences in Emotion Recognition in Multi-concussed Athletes

Léveillé

Guay

Blais

et al. 2016

J Int Neuropsychol Soc

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Male concussed athletes were significantly impaired in recognizing negative emotions and needed more emotional intensity to correctly identify these emotions, compared to same-sex controls. In contrast, female concussed athletes performed similarly to same-sex controls. These findings suggest that sex significantly modulates concussion effects on emotional facial expression recognition. (JINS, 2017, 23, 65-77).

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Impact of BDNF Val66Met polymorphism on olfactory functions of female concussed athletes

Abstract: These results support a genotypic effect of the BDNF Val66Met polymorphism on long-term olfactory function following a concussion in young female athletes.

Cited by 12 publications

References 61 publications

Olfactory Dysfunction in Sports Players following Moderate and Severe Head Injury: A Possible Cut-off from Normality to Pathology

Olfactory Dysfunction in Sports Players following Moderate and Severe Head Injury: A Possible Cut-off from Normality to Pathology

The Influence of the Val66Met Polymorphism of Brain-Derived Neurotrophic Factor on Neurological Function after Traumatic Brain Injury

Sex-Related Differences in Emotion Recognition in Multi-concussed Athletes

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