Impact of Bisphenol A on the Cardiovascular System — Epidemiological and Experimental Evidence and Molecular Mechanisms

Abstract

Bisphenol A (BPA) is a ubiquitous plasticizing agent used in the manufacturing of polycarbonate plastics and epoxy resins. There is well-documented and broad human exposure to BPA. The potential risk that BPA poses to the human health has attracted much attention from regulatory agencies and the general public, and has been extensively studied. An emerging and rapidly growing area in the study of BPA’s toxicity is its impact on the cardiovascular (CV) system. Recent epidemiological studies have shown that higher urinary BPA concentration in humans is associated with various types of CV diseases, including angina, hypertension, heart attack and coronary and peripheral arterial disease. Experimental studies have demonstrated that acute BPA exposure promotes the development of arrhythmias in female rodent hearts. Chronic exposure to BPA has been shown to result in cardiac remodeling, atherosclerosis, and altered blood pressure in rodents. The underlying mechanisms may involve alteration of cardiac Ca2+ handling, ion channel inhibition/activation, oxidative stress, and genome/transcriptome modifications. In this review, we discuss these recent findings that point to the potential CV toxicity of BPA, and highlight the knowledge gaps in this growing research area.

Influence of bisfenol A on chemical coding of the nerve fibers of the cardiac apex in the domestic pig

“…Jednym z nich jest wpływ tej substancji na unerwienie serca. Dotychczasowe badania potwierdziły możliwość odkładania się BPA w mięśniu sercowym (16,44). Ponadto wykazano, iż substancja ta może powodować arytmię (43) oraz przyczyniać się do różnorodnych chorób serca, takich jak zawał mięśnia sercowego czy choroba niedokrwienna serca.…”

“…Ponadto wykazano, iż substancja ta może powodować arytmię (43) oraz przyczyniać się do różnorodnych chorób serca, takich jak zawał mięśnia sercowego czy choroba niedokrwienna serca. Stwierdzono także, że ekspozycja na bisfenol A zwięk-sza ryzyko nadciśnienia i choroby wieńcowej (3,16,20). Pomimo stosunkowo znacznej liczby badań na temat negatywnego wpływu BPA na układ sercowo--naczyniowy (1,2,12,15,34), dokładny mechanizm tego działania nie został do końca poznany.…”

The Interaction of C - Reactive Protein, Bisphenol A, & Cardiovascular Disease: A Demographical Analysis

“…Numerous types of cardiovascular diseases including hypertension, angina, peripheral and coronary arterial disease and heart attack have been caused due to the concentration of higher urinary BPA in humans (Carwile et al, 2009). It has been observed in previous studies that the exposure of acute BPA usually supports the growth of arrhythmias in female rodent hearts (Gao & Wang, 2014). The chronic kidney disease is also a major illness caused by BPA, which is related to urinary Albuminuria and blood pressure.…”

Bioremediation of Waters Polluted by Endocrine Disruptors by Means of the Process of Thermodialysis

“…EDCs have been proved to induce cancer [1], to damage the male and female reproductive system [2 -4], to induce obesity [5,6] and cardiovascular diseases [7,8]. A great number of compounds have been identified as belonging to this group of chemicals: natural and synthetic steroid hormones, phytoestrogens, alkylphenols, phthalates, pesticides, surfactants and polychlorinated biphenyls.…”