Impact of calcification and intraluminal thrombus on the computed wall stresses of abdominal aortic aneurysm

Li, Zhiyong; U-King-Im, Jean Marie; Tang, Tjun Yip; Soh, Edmund; See, Teik Choon; Gillard, Jonathan H.

doi:10.1016/j.jvs.2008.01.006

Cited by 184 publications

(148 citation statements)

References 47 publications

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“…It may well result from the formation of ILT at the previous "shoulder area," which tends to reduce the stress in the AAA. 10 Although no concomitant increase from baseline for the overall stress, overall maximum diameter stress, and overall shoulder stress was observed, a positive correlation between the expansion rate and the shoulder stress was identified. Further analysis of the 2 groups revealed that this relationship exists for rapidly expanding aneurysms only and not for slowly expanding aneurysms.…”

Section: Et Al Shoulder Stress and Aneurysm Growthmentioning

confidence: 82%

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Association Between Aneurysm Shoulder Stress and Abdominal Aortic Aneurysm Expansion

Sadat²,

U-King-Im³

et al. 2010

Circulation

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Background-Aneurysm expansion rate is an important indicator of the potential risk of abdominal aortic aneurysm (AAA) rupture. Stress within the AAA wall is also thought to be a trigger for its rupture. However, the association between aneurysm wall stresses and expansion of AAA is unclear. Methods and Results-Forty-four patients with AAAs were included in this longitudinal follow-up study. They were assessed by serial abdominal ultrasonography and computed tomography scans if a critical size was reached or a rapid expansion occurred. Patient-specific 3-dimensional AAA geometries were reconstructed from the follow-up computed tomography images. Structural analysis was performed to calculate the wall stresses of the AAA models at both baseline and final visit. A nonlinear large-strain finite element method was used to compute the wall-stress distribution. The relationship between wall stresses and expansion rate was investigated.

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Section: Et Al Shoulder Stress and Aneurysm Growthmentioning

confidence: 82%

“…9,10 A patientspecific study previously demonstrated that maximum wall stress was 12% more specific and 13% more sensitive in predicting AAA rupture than maximum diameter alone. 11 In other patient-specific studies, peak stress was found to be significantly higher in ruptured AAAs than nonruptured AAAs.…”

Section: Clinical Perspective On P 1822mentioning

confidence: 99%

Association Between Aneurysm Shoulder Stress and Abdominal Aortic Aneurysm Expansion

Sadat²,

U-King-Im³

et al. 2010

Circulation

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“…The ratio of the vessel stress to vessel strength is regarded as an alternative tool to conventional diameter criteria, which may be insufficient in small aneurysms. In computational simulations, vessel stress is calculated as a function of the vessel diameter [7,34], wall thickness [36,37], asymmetry [14,18,34,36], tortuosity [21], material property [17,24,29,38], calcification [15,22], intraluminal thrombus (ILT) [5,15,16,33], and blood flow [4, 9, 13, 14, 17, 20, 25, 26, 28-30, 32, 35-41]. Blood vessel strength is measured by ex vivo studies [11,12,23,31,44] or estimated by effective features such as ILT existence, sex, and genetic vulnerability [10].…”

mentioning

confidence: 99%

Investigation of material modeling in fluid–structure interaction analysis of an idealized three-layered abdominal aorta: aneurysm initiation and fully developed aneurysms

Şimşek

Kwon

2015

J Biol Phys

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Different material models for an idealized three-layered abdominal aorta are compared using computational techniques to study aneurysm initiation and fully developed aneurysms. The computational model includes fluid-structure interaction (FSI) between the blood vessel and the blood. In order to model aneurysm initiation, the medial region was degenerated to mimic the medial loss occurring in the inception of an aneurysm. Various cases are considered in order to understand their effects on the initiation of an abdominal aortic aneurysm. The layers of the blood vessel were modeled using either linear elastic materials or Mooney-Rivlin (otherwise known as hyperelastic) type materials. The degenerated medial region was also modeled in either linear elastic or hyperelastic-type materials and assumed to be in the shape of an arc with a thin width or a circular ring with different widths. The blood viscosity effect was also considered in the initiation mechanism. In addition, dynamic analysis of the blood vessel was performed without interaction with the blood flow by applying time-dependent pressure inside the lumen in a three-layered abdominal aorta. The stresses, strains, and displacements were compared for a healthy aorta, an initiated aneurysm and a fully developed aneurysm. The study shows that the material modeling of the vessel has a sizable effect on aneurysm initiation and fully developed aneurysms. Different material modeling of degeneration regions also affects the stressstrain response of aneurysm initiation. Additionally, the structural analysis without considering FSI (called noFSI) overestimates the peak von Mises stress by 52% at the interfaces of the layers.

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“…Although, there is a lack of agreement on how calcifications actually affect it. Since the discussed constituent is stiffer than the rest of the wall, it presents possible stress concentration which is consistent with higher rupture probability [32,33]. On the other hand, calcifications cause local wall thickening [11] and demonstrate significant loadbearing effects, which results in lowering the wall stress [34].…”

Section: Presence Of Intraluminal Thrombus and Calcifications In Aaa mentioning

confidence: 77%

Biomechanical factors in Finite Element Analysis of abdominal aortic aneurysms

et al. 2017

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Impact of calcification and intraluminal thrombus on the computed wall stresses of abdominal aortic aneurysm

Cited by 184 publications

References 47 publications

Association Between Aneurysm Shoulder Stress and Abdominal Aortic Aneurysm Expansion

Association Between Aneurysm Shoulder Stress and Abdominal Aortic Aneurysm Expansion

Investigation of material modeling in fluid–structure interaction analysis of an idealized three-layered abdominal aorta: aneurysm initiation and fully developed aneurysms

Biomechanical factors in Finite Element Analysis of abdominal aortic aneurysms

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