Impact of calcium ion on cytotoxic effect of the boroxine derivative, K₂[B₃O₃F₄OH]

Abstract

Abstract

Novel boron‐containing compound, halogenated boroxine, induces selective cytotoxicity through apoptosis triggering in UT‐7 leukemia

“…The cytotoxic effects of HB in various tumors [17][18][19][20] and healthy cells [20,26,27] are known but neither the mechanism of its action nor the effects on hematological tumors are clear. In this study, UT-7 cell viability was reduced in HB dose-dependent manner along with the increase of cytotoxicity confirming an overall decrease of UT-7 proliferation [36] in accordance with the confirmed HB effects in vitro.…”

“…In mouse adenocarcinoma, melanoma, and squamous cell carcinoma cell lines, the cytotoxicity and antiproliferative effects are significant, while in an in vivo model this effect is manifested by slowing tumor growth. [17,18] HB in GR-M human melanoma cells induces cytotoxicity and deregulates more than 30 genes considered as molecular antitumor targets, including reduced expression of IGF-1 and hTERT genes. [19] HB also inhibits the growth of human basal cell carcinoma and peripheral blood lymphocytes in vitro [20] and has a pronounced potential in inhibiting different enzymes.…”

Ba3(BO3)(CO3)F: The First Borate Carbonate Fluoride Synthesized by the High‐Temperature Solution Method

“…To date, more than 3000 natural and synthetic borates have been discovered and reported. With such a large base, borate is widely used for design of materials in frontier fields, such as novel photonic and optoelectronic devices, rechargeable batteries, nuclear waste separation and sequestration, as well as biomedical domain [4–15] . For the inorganic crystals, carbonate also has a rich diversity and a huge number of structure types.…”

In Vitro Study of the Anti-Proliferative Effects of Dipotassium-Trioxohydroxytetrafluorotriborate on the H520 Non-Small Cell Lung Cancer Cell Line

“…Higher tested concentrations of K 2 (B 3 O 3 F 4 OH) (0.5 mg/ml and 1 mg/ml) were highly cytotoxic in all tested tumor lines. Effects of K 2 (B 3 O 3 F 4 OH) on the growth inhibition of tumor cells are significant in the growing medium containing low levels of Ca2+ ions (0.42 mM) (Ivankovic et al, 2016). In vivo, regardless of the administration mode used (intraperitoneally, intratumor, per os or topical) K 2 (B 3 O 3 F 4 OH) slowed the growth of all three tested tumor types compared to the controls (Ivankovic et al, 2015).…”