Impact of cardiac surgery on plasma levels of B-type natriuretic peptide in children with congenital heart disease

Does B-type Natriuretic Peptide Level Predict Outcome After Arterial Switch Operation ?

“…In this clinical trial we indicated that the mean of BNP 24 hours after operation significantly increased (7989.96±9691.94 vs.22391.35±11898.67, P=0.003), moreover in four patients that died after operation the mean of BNP plasma level was higher than other(35000 vs. 22391)and the correlation between death and BNP was significant(p=0.001).In agreement to our results Koch et al in a study signified that in children with congenital heart defects plasma BNP level increased immediately after cardiac surgery 23 .Moreover another study by Shih etal.showed B-type natriuretic peptide levels increased after separation from cardiopulmonary bypass, with an 8-fold peak increase at 12 hours 24 .However, in contrast to our results HSU et al evaluated the plasma B-type natriuretic peptide levels in 36 consecutive neonates and indicated that B-type natriuretic peptide levels at 24 hours were lower than preoperative levels 12 .Moreover Sanjeevet alin another survey specified that elevation of plasma BNP accurately detects the presence of PDA in premature infants. Also, theydesignated that successful closure is reflected by a corresponding decrease in BNP plasma level in neonates 25 .A possible explanation for such a discrepancy between studies is heterogeneity in patient's samples and different technique in BNP measurement.…”

A clinical importance of natriuretic peptides in pediatric practice

“…после вмешательства. уровень BNP кор-релировал с длительностью искусственного кровообра-щения и уровнем лактата в первые сутки послеопераци-онного периода [57].…”

B-Type Natriuretic Peptide (BNP) in Neonates, Infants and Children Undergoing Cardiac Surgery

“…BNP levels increased postoperatively, and remained elevated over the first postoperative day. The increase in BNP from baseline to 12 hours was associated with the cardiopulmonary bypass time.Koch and colleagues measured BNP levels in 65 pediatric patients (age 4 days -17 years, mean age of 3.6), undergoing surgical repair of congenital cardiac defects preoperatively, and for one week after surgery (Koch, Kitzsteiner, et al 2006). BNP levels increased after surgery (from a median of 31 pg/ml to 453 pg/ml) and remained elevated over the first week, with a bimodal pattern (initial peak at 1.3 days and a second peak at 5.1 days after surgery).…”