Impact of cellular CD71 (transferrin receptor 1) expression in Egyptian acute leukemia: correlation with clinicopathologic features

El-Menshawy, Nadia; Abd-Aziz, Sherin M.; Ebrahim, Mohammed A.; Elmalky, Nader

doi:10.1007/s00580-015-2213-x

Cited by 3 publications

(4 citation statements)

References 23 publications

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“…The difference between our results and that of Menshawy et al [34] may be due to reliance of the latter on MFI as a measure of antigenic expression. Both Park et al .…”

Section: Discussioncontrasting

confidence: 99%

“…These results were in contrast to El-Menshawy et al [34] who studied CD71 expression in Egyptian population and demonstrated that CD71 is over expressed in ALL rather than AML. When comparing different FAB subtypes of AML with each other regarding expression percentage and MFI, we found that the highest CD71 % expression was for M7 then poorly differentiated AML (M0, M1, M2, M4) then partially differentiated AML while precursor B-ALL was negative for this marker despite being of higher fluorescence intensity than AML similar to results by Liu et al [28] except for AML M3 which despite being partially differentiated however showed higher expression than most of poorly differentiated AML.…”

Section: Discussioncontrasting

confidence: 95%

“…When comparing different FAB subtypes of AML with each other regarding expression percentage and MFI, we found that the highest CD71 % expression was for M7 then poorly differentiated AML (M0, M1, M2, M4) then partially differentiated AML while precursor B-ALL was negative for this marker despite being of higher fluorescence intensity than AML similar to results by Liu et al [28] except for AML M3 which despite being partially differentiated however showed higher expression than most of poorly differentiated AML. However, in contrast to El-Menshawy et al [34] who found that there was an increased expression of CD71 in AML, M3, M4, and M5, partially differentiated myeloid leukemia with little maturation evidence along with high proliferation capacity.…”

Section: Discussioncontrasting

confidence: 57%

“…A significant negative correlation was found between mean fluorescence intensity of CD71 and each of age, TLC, CD13 and CD14 and a significant positive correlation with common lymphoid markers; CD10, CD19, CD20 while showed no significant correlation with any of clinicopathologic features. These results were in comparison to El-Menshawy et al [34] who found CD71 expression to correlate positively with total leukocyte count in ALL patients and negatively with platelet count in AML cases and Das Gupta et al [22] in his study…”

Section: Discussionmentioning

confidence: 43%

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Evaluation of CD71 Expression in Acute Leukemia in Egyptian Patients

El-Sakhawy¹

2016

jmscr

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“…The difference between our results and that of Menshawy et al [34] may be due to reliance of the latter on MFI as a measure of antigenic expression. Both Park et al .…”

Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 95%

Section: Discussioncontrasting

confidence: 57%

Section: Discussionmentioning

confidence: 43%

See 2 more Smart Citations

Evaluation of CD71 Expression in Acute Leukemia in Egyptian Patients

El-Sakhawy¹

2016

jmscr

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Arsenite exposure inhibits the erythroid differentiation of human hematopoietic progenitor CD34+ cells and causes decreased levels of hemoglobin

Wan

Medina

Zhang

et al. 2021

Sci Rep

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Arsenic exposure poses numerous threats to human health. Our previous work in mice has shown that arsenic causes anemia by inhibiting erythropoiesis. However, the impacts of arsenic exposure on human erythropoiesis remain largely unclear. We report here that low-dose arsenic exposure inhibits the erythroid differentiation of human hematopoietic progenitor cells (HPCs). The impacts of arsenic (in the form of arsenite; As3+) on red blood cell (RBC) development was evaluated using a long-term culture of normal human bone marrow CD34+-HPCs stimulated in vitro to undergo erythropoiesis. Over the time course studied, we analyzed the expression of the cell surface antigens CD34, CD71 and CD235a, which are markers commonly used to monitor the progression of HPCs through the stages of erythropoiesis. Simultaneously, we measured hemoglobin content, which is an important criterion used clinically for diagnosing anemia. As compared to control, low-dose As3+ exposure (100 nM and 500 nM) inhibited the expansion of CD34+-HPCs over the time course investigated; decreased the number of committed erythroid progenitors (BFU-E and CFU-E) and erythroblast differentiation in the subsequent stages; and caused a reduction of hemoglobin content. These findings demonstrate that low-dose arsenic exposure impairs human erythropoiesis, likely by combined effects on various stages of RBC formation.

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Diagnostic value and biological significance of CD71 in lymphoid disorders

Mahmoud,

Eldeen,

Fahmy

2023

EGJH

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Background The CD71 expression is tightly regulated by intracellular iron level, cell proliferation, or erythropoiesis at levels of receptor recycling, as well as transcriptional or posttranscriptional control. In the previous studies, CD71 was expressed by most of acute leukemia and chronic granulocytic leukemia in blast crisis with a variable density of expression. Only few studies have observed CD71 as a diagnostic and prognostic marker in cases of acute lymphocytic leukemia (ALL) as a type of acute leukemia. Therefore, our study aimed to evaluate the diagnostic and biological significance of CD71 in lymphoid disorders. Aim and objectives This study aimed to evaluate the diagnostic value and biological significance of CD71 in lymphoid disorders. Patients and methods The present research was carried out on 60 patients diagnosed with lymphoid disorders (benign lymphocytosis, ALL, CLL, lymphoma, and multiple myeloma) who presented to Assiut University Hospital from July 2020 till July 2021. Results CD71 expression was significantly higher in acute disorders (immature cell-type tumors of malignant lymphoid disorders) than in benign lymphocytosis and chronic disorders (immature cell-type tumors of malignant lymphoid disorders), with strong relation with the positivity of CD34 and TdT. Conclusion CD71 helps to differentiate between lymphoid disorders and further helps in discriminating the differentiation status of ALL. High expression of CD71 might reflect a much more aggressive and immature cell type. However, further prospective investigations are needed to document the possible relation of CD71 with response to treatment and relapse rate. Moreover, high expression of CD71 with clonal evolution in leukemia may predict the possibility of being an important molecular target in future therapy of acute leukemia.

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Impact of cellular CD71 (transferrin receptor 1) expression in Egyptian acute leukemia: correlation with clinicopathologic features

Cited by 3 publications

References 23 publications

Evaluation of CD71 Expression in Acute Leukemia in Egyptian Patients

Evaluation of CD71 Expression in Acute Leukemia in Egyptian Patients

Arsenite exposure inhibits the erythroid differentiation of human hematopoietic progenitor CD34+ cells and causes decreased levels of hemoglobin

Diagnostic value and biological significance of CD71 in lymphoid disorders

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