The prevalence of HCV and HBV infections are very high among Egyptian β-thalassemic patients, which calls for a critical look into the prevailing transfusion practices and adoption of stricter donor selection criteria to decrease the incidence rate of both HCV and HBV infections effectively. Furthermore, there is a compressing need for the use of more specific and sensitive methods for HCV testing in Mansoura university hospitals.

No abstract

Mutation in IDH1 gene was suggested to be associated with bad prognosis in cytogenetically normal AML (CN-AML). However, there are conflicting data about its prognostic impact. Besides, its prevalence and prognostic significance in Egyptian patients still not fully stated. We aimed to assess the prevalence of IDH1 mutation in Egyptian CN-AML patients, its correlation with FAB subtypes, and clinical outcome of those patients. Sequencing of amplified IDH1 gene exon four from 50 patients was performed to detect codon R132 point mutation. High prevalence of IDH1 mutation was detected in our patients (9/50, 18 %). Mutated IDH1 was associated with older age and higher platelets count ( = 0.04 and 0.01 respectively). The most common FAB subtype associated with mutated IDH1 was AML-M2 followed by M4. In multivariate analysis, IDH1 mutation was found as independent prognostic variable. It was significantly associated with lower CR and shorter OS ( = 0.06 and 0.009 respectively).

Different cellular MPs and platelets activated in HIV patients could have a role in thrombotic events in these patients.

No abstract