Impact of Changes in Gastrointestinal Microbiota in Canine and Feline Digestive Diseases

Ziese, Anna-Lena; Suchodolski, Jan S.

doi:10.1016/j.cvsm.2020.09.004

Cited by 49 publications

(80 citation statements)

References 51 publications

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“…Several other metabolites that were at lower levels with the test food are also associated with kidney dysfunction, such as the urea cycle metabolites citrulline, urea, and dimethylarginine. Others include tryptophan and tyrosine metabolites, some of which can act as uremic toxins [35], and methylguanidine, which was seen at higher levels in plasma and urinary excretion in dogs with chronic renal failure [36]. Plasma levels of guanidinoacetate, a precursor to creatinine, were also lower following consumption of the test food in the present study.…”

Section: Discussionsupporting

confidence: 46%

Effect of Nutrition on Age-Related Metabolic Markers and the Gut Microbiota in Cats

Ephraim¹,

Jewell

2021

Microorganisms

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Age-related changes in the gut microbiota and metabolites are associated with the increased risk of detrimental conditions also seen with age. This study evaluated whether a test food with potential anti-aging benefits results in favorable changes in plasma and fecal metabolites and the fecal microbiota in senior cats. Forty healthy domestic cats aged 8.3–13.5 years were fed a washout food for 30 days, then control or test food for 30 days. After another 30-day washout, cats were switched to the other study food for 30 days. Assessment of plasma and fecal metabolites showed lower levels of metabolites associated with detrimental processes (e.g., uremic toxins) and higher levels of metabolites associated with beneficial processes (e.g., tocopherols) after cats consumed the test food compared with the control food. A shift toward proteolysis with the control food is supported by higher levels of amino acid metabolites and lower levels of carbohydrate metabolites. Operational taxonomic units of greater abundance with the test food positively correlated with carbohydrate and nicotinic acid metabolites, and negatively correlated with uremic toxins, amino acid metabolism, secondary bile salts, and branched-chain fatty acids. Taken together, the test food appears to result in greater levels of metabolites and microbiota associated with a healthier state.

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Section: Discussionsupporting

confidence: 46%

Effect of Nutrition on Age-Related Metabolic Markers and the Gut Microbiota in Cats

Ephraim¹,

Jewell

2021

Microorganisms

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“…In humans and in dogs, both chronic and acute enteropathies exhibit imbalanced composition of intestinal microbiota, defined as dysbiosis, which has been recognized as a major player in the development of these diseases [2][3][4][5][6]. Moreover, as previously reported, CE are characterized by decreased faecal bacterial diversity and richness [7] with possible impact on the primary functions of gut microbiota. These functions include protection against pathogenic challenge, maturation of the host's innate and adaptive immune responses, regulation of the host's metabolism, and maintenance of the structural integrity of the gut mucosal barrier [8].…”

Section: Introductionmentioning

confidence: 83%

Faecal Microbiome Transplantation as a Solution to Chronic Enteropathies in Dogs: A Case Study of Beneficial Microbial Evolution

Berlanda

Innocente²,

Simionati³

et al. 2021

Animals

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Chronic enteropathies (CE) are gastrointestinal diseases that afflict about one in five dogs in Europe. Conventional therapeutic approaches include dietary intervention, pharmacological treatment and probiotic supplements. The patient response can be highly variable and the interventions are often not resolutive. Moreover, the therapeutic strategy is usually planned (and gradually corrected) based on the patient’s response to empirical treatment, with few indirect gut health indicators useful to drive clinicians’ decisions. The ever-diminishing cost of high-throughput sequencing (HTS) allows clinicians to directly follow and characterise the evolution of the whole gut microbial community in order to highlight possible weaknesses. In this framework, faecal microbiome transplantation (FMT) is emerging as a feasible solution to CE, based on the implant of a balanced, eubiotic microbial community from a healthy donor to a dysbiotic patient. In this study, we report the promising results of FMT carried out in a 9-year-old dog suffering from CE for the last 3 years. The patient underwent a two-cycle oral treatment of FMT and the microbiota evolution was monitored by 16S rRNA gene sequencing both prior to FMT and after the two administrations. We evaluated the variation of microbial composition by calculating three different alpha diversity indices and compared the patient and donor data to a healthy control population of 94 dogs. After FMT, the patient’s microbiome and clinical parameters gradually shifted to values similar to those observed in healthy dogs. Symptoms disappeared during a follow-up period of six months after the second FMT. We believe that this study opens the door for potential applications of FMT in clinical veterinary practice and highlights the need to improve our knowledge on this relevant topic.

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“…The intestinal microbiome, a separate organ, takes part in a variety of pathways [ 32 ]. These metabolic pathways of the intestinal microbiota and their effects on the host are described in Table 1 .…”

Section: Gut Microbiomementioning

confidence: 99%

Any Future for Faecal Microbiota Transplantation as a Novel Strategy for Gut Microbiota Modulation in Human and Veterinary Medicine?

Takáčová

Bomba²,

Tóthová

et al. 2022

Life

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Alterations in the composition of the intestinal microbiome, also known as dysbiosis, are the result of many factors such as diet, antibiotics, stress, diseases, etc. There are currently several ways to modulate intestinal microbiome such as dietary modulation, the use of antimicrobials, prebiotics, probiotics, postbiotics, and synbiotics. Faecal microbiota transplantation (FMT) represents one new method of gut microbiota modulation in humans with the aim of reconstructing the intestinal microbiome of the recipient. In human medicine, this form of bacteriotherapy is successfully used in cases of recurrent Clostridium difficile infection (CDI). FMT has been known in large animal medicine for several years. In small animal medicine, the use of FMT is not part of normal practice.

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Impact of Changes in Gastrointestinal Microbiota in Canine and Feline Digestive Diseases

Cited by 49 publications

References 51 publications

Effect of Nutrition on Age-Related Metabolic Markers and the Gut Microbiota in Cats

Effect of Nutrition on Age-Related Metabolic Markers and the Gut Microbiota in Cats

Faecal Microbiome Transplantation as a Solution to Chronic Enteropathies in Dogs: A Case Study of Beneficial Microbial Evolution

Any Future for Faecal Microbiota Transplantation as a Novel Strategy for Gut Microbiota Modulation in Human and Veterinary Medicine?

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