Impact of chloroquine resistance on malaria mortality

A Molecular Marker for Chloroquine-Resistant Falciparum Malaria

“…9 The higher serum urea nitrogen concentrations in these children may reflect the chronic nature of diabetic ketoacidosis, because a long duration of symptoms has previously been associated with development of cerebral edema. 3 The data presented by Glaser et al confirm previous reports that the administration of bicarbonate may be a risk factor for cerebral edema in children with diabetic ketoacidosis; however, over the past 10 years,…”

“…In Senegal, the emergence of chloroquine resistance over a 12-year period was associated with at least a doubling of the risk of death from malaria in children younger than 10 years of age. 3 The transmission of resistant strains can be facilitated by unsuccessful treatment. 4 Electron-microscopical analysis of malaria parasites in red cells of mice and monkeys treated with chloroquine shows that the parasite's lysosome, where hemoglobin is digested, is affected first.…”

Malaria: current status of control, diagnosis, treatment, and a proposed agenda for research and development

“…7 The single well-documented study to date on the effect on mortality of resistance to chloroquine concluded that the development of resistance had resulted in a four to eight fold increase in mortality. 8 Inadequate epidemiological data create many problems, justifying inaction and preventing the policy changes that would allow deployment of effective treatments.…”

“…74,75 The use of a drug for which there is widespread resistance leads to increased malaria mortality and morbidity. 8,76 As resistance increases, the duration of clinical improvement is shortened and haematological recovery after treatment is impaired. 77 A shortened period of clinical relief means that many children never become truly healthy.…”

Combining Artesunate-Amodiaquine and Ciprofloxacin Improves Serum Lipid Profile of Mice Exposed to Plasmodium Berghei Berghei

“…Antimalarial chemotherapy has been the primary option in the fight against malaria. However, the burden of this disease is still very heavy partly due to the development of multi-drug resistant Plasmodium falciparum strains [7][8][9] African countries have recently stepped up their antimalarial efforts, and are deploying diverse strategies to contend the ne w face of malaria. One of these strategies is the use of artemisinin-based combination therapies (ACTs) recommended by WHO, which have proven to be very effective against malaria in sub Saharan Africa, and some African countries plagued with resistant forms of P.falciparum have started instituting the ACTs as first line malaria treatment 10,11 Artesunate plus amodiaquine combination is one Artemisinin-based combination therapy (ACT) recommended by the World Health Organization (WHO) for use in malaria control programmes and a first line treatment for African patients with uncomplicated malaria 11 .…”