Impact of Chronic Oral Administration of Silver Nanoparticles on Cognitive Abilities of Mice

Abstract

To assess the effect of silver nanoparticles on mice cognitive abilities, daily, up to 4-month period, experimental mice were administrated with silver nanoparticles solution. Accumulation of silver in brain was assessed by neutron activation analysis. Cognitive abilities in mice before and after silver nanoparticles administration were evaluated in the Morris water maze behavioral test. No significant differences in the amounts of silver accumulated in brain were found between capable and incapable animals. Silver accumulation in brain of experimental animals in 4-months experiment was higher than in 2-months experiment for both groups. In the main Morris water maze behavioral test at the control points of 2 and 4 months no statistically significant differences were found in the parameters of treks between experimental and control animals.

The effect of silver nanoparticles on learning and memory in rodents: "a systematic review"

“…Results from the MWM of the main test have statistically demonstrated no significant differences in parameters’ values among experimental groups compared to controls. So, it is concluded that Ag-NPs with a dosage of 13 mg/ml and size of 34 ± 1.4 nm in mice treated for 2 and 4 months do not affect spatial learning and memory [ 22 ].…”

Impact of Chronic Oral Administration of Gold Nanoparticles on Cognitive Abilities of Mice

“…Assessment of spatial learning and memory. One cycle of testing (three days of primary learning) was performed in the Morris water maze (MWM), according to the early developed protocol of the testing [37,38] with additional assessment of the flexibility of developed spatial memory by subsequent re-positioning of the platform into the other part of the swimming pool (fourth day) [39]. The circular white pool (1.5 m in diameter) was filled with water, and various visible clues were positioned around the pool.…”

“…For each animal was determined the behavioral type was demonstrated during trials in three days of primary learning. Similarly to the previously developed protocol [40], the general sample was divided into three groups, "incapable", "capable", and "intermediate" animals, based on the type of behavior most frequently shown on Day 3. Incapable mice were excluded from the MWM as being non-responsive to potential changes induced by AuNPs that could be detected in this test; they demonstrated types of behavior, which did not include exploration of the pool.…”