Impact of Chronic Periodontitis on Systemic Conditions: A Review

Saranyan, R.; Manovijay, B; Priya, K; Jayachandran, D; Babu, B Balaji; Raj, Caroline

doi:10.9734/ajmah/2017/38511

Cited by 1 publication

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“…Its origins have been traced back to the oral microbiota, immune system responses, and genetic constitution of the host ( Figure 1 ) (Kinane et al, 2017 ). However, due to the complexity of the responses and the heterogeneity of the evidence, the actual roles, and mechanistic details of the relationship between periodontitis and systemic diseases are still being debated (Saranyan et al, 2017 ; Ide, 2021 ).…”

Section: Biological Aspects Of Periodontal Inflammationmentioning

confidence: 99%

Periodontal Inflammation and Systemic Diseases: An Overview

2021

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Periodontitis is a common inflammatory disease of infectious origins that often evolves into a chronic condition. Aside from its importance as a stomatologic ailment, chronic periodontitis has gained relevance since it has been shown that it can develop into a systemic condition characterized by unresolved hyper-inflammation, disruption of the innate and adaptive immune system, dysbiosis of the oral, gut and other location's microbiota and other system-wide alterations that may cause, coexist or aggravate other health issues associated to elevated morbi-mortality. The relationships between the infectious, immune, inflammatory, and systemic features of periodontitis and its many related diseases are far from being fully understood and are indeed still debated. However, to date, a large body of evidence on the different biological, clinical, and policy-enabling sources of information, is available. The aim of the present work is to summarize many of these sources of information and contextualize them under a systemic inflammation framework that may set the basis to an integral vision, useful for basic, clinical, and therapeutic goals.

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Section: Biological Aspects Of Periodontal Inflammationmentioning

confidence: 99%