Impact of cigarette smoking on response to interferon therapy in chronic hepatitis C Egyptian patients

Abstract

AIM:Smoking may affect adversely the response rate to interferon-α. Our objective was to verify this issue among chronic hepatitis C patients.

Impact of duration of therapy on side effect profile of anti-HCV protocol: A retrospective cohort study from two tertiary health facilities in Pakistan

“…Similar results have been reported previously, suggesting that these risk factors can prolong therapy duration which may result in serious side effects [22]. Smoking increases the chances of fibrosis and damage to the liver in patients with chronic hepatitis C [23].…”

Outcome of Sofosbuvir containing Treatment Regimens in Egyptian Chronic Hepatitis C Patients with Thrombocytopenia

“…El-Zayadi et al [18] reported in their study that smoking decreased response to treatment and decreased sustained virological response and explained that by patients with chronic HCV have lower levels of hepatic, plasma and lymphocytic glutathione that favor the hepatotoxic effect of smoking and reduce efficacy of treatment, but current study couldn't conclude these results.…”

A closer look at pain and hepatitis C: Preliminary data from a veteran population

“…Smoking was more prevalent in this sample than a normative comparison sample of veterans (45.8% vs 33.9%, respectively) [72]. This finding is particularly important because recent studies suggest that cigarette smoking aggravates liver functioning, increases the risk of liver fibrosis, and decreases the efficacy of IFN treatment [73][74][75]. Alcohol use was also very prevalent in our sample and at an intensity that is described as "risky or hazardous" and in need of further assessment.…”