Impact of citrate therapy on the circadian rhythm of urinary magnesium ammonium phosphate saturation in normal individuals

Ogawa, Yoshihide; Sugaya, Kimio; Koyama, Yuzo; Hatano, Tadashi

doi:10.1046/j.1442-2042.2000.00196.x

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…(4) Insufficient concentration data of substances that affect the solubility of uric acid in urine. Ogawa reported circadian variations in the relative supersaturation of uric acid, sodium urate, and ammonium urate 25 . As the trials did not provide sufficient data, further studies are needed to analyze the relative supersaturation, which may be useful for examining the pharmacokinetics of urinary uric acid in patients treated with dotinurad.…”

Section: Discussionmentioning

confidence: 99%

Changes in Urinary Uric Acid Concentration after Dotinurad Administration to Patients with Hyperuricemia: A Post Hoc Analysis of Two Clinical Trials in Japan

Takahashi

Sasaki²,

Shimizu

et al. 2023

Clinical Pharm in Drug Dev

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Dotinurad has been approved in Japan as a selective urate reabsorption inhibitor for the treatment of gout and hyperuricemia. The relationship between uric acid crystallization and the use of uricosuric drugs is widely acknowledged; however, the relationship between changes in urinary uric acid concentration and urine pH or volume has not been sufficiently analyzed. Therefore, we investigated the changes in urinary uric acid concentration following dotinurad administration as well as the relationship between urine pH or volume and urinary uric acid concentration. This post hoc analysis used data from 2 clinical trials that included 12 and 26 patients with hyperuricemia who received dotinurad treatment (for 7 days on an inpatient basis and 14 weeks on an outpatient basis, respectively). The urinary uric acid concentration transiently increased in the early stages of dotinurad use and when its dose was increased, but decreased over time. No uric acid concentrations exceeded the soluble limit at any urine pH. An inverse correlation was observed between urine volume and urinary uric acid concentration. This study highlights the significance of adequately managing urinary uric acid concentrations by increasing urine volume and alkalinizing urine to prevent uric acid crystallization during dotinurad administration.

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Section: Discussionmentioning

confidence: 99%

Changes in Urinary Uric Acid Concentration after Dotinurad Administration to Patients with Hyperuricemia: A Post Hoc Analysis of Two Clinical Trials in Japan

Takahashi

Sasaki²,

Shimizu

et al. 2023

Clinical Pharm in Drug Dev

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Urinary Stone Inhibitors

Abrahams¹,

Meng²,

Stoller³

Urinary Stone Disease

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Urinary stone disease has afflicted mankind for centuries and continues to be a significant medical ailment throughout the world. Contemporary management reflects the changes and evolution that have occurred in both medicine and, specifically, urology. Traditional open surgery has been nearly replaced by minimally invasive techniques, the result of technologic innovations, miniaturization of instruments, and interdisciplinary collaboration. Nevertheless, nephrolithiasis remains a chronic disease and our fundamental understanding of the pathogenesis, and molecular and genetic basis of stones as well as their prevention, remains rudimentary.All large calculi were once small calculi. Where do stones originate and what facilitates their retention, allowing them to grow? Although we rely on 24-hour urinary collections, clearly our current methods of directing medical therapy have limitations. In addition, interest in disease prevention continues to grow and understanding basic questions and the underlying pathophysiology of stone disease will help optimize management strategies.Future advances in urinary stone disease will be the result of collaboration among urologists, nephrologists, radiologists, dieticians, scientists, and partners in industry. Physicians must not be complacent with the current status quo or be overly eager to intervene because techniques are less invasive; rather, the goals should be a better understanding of the underlying disease process in order to identify those at risk, prophylax against stone development and recurrence, and improved nonsurgical therapies.Urinary Stone Disease: The Practical Guide to Medical and Surgical Management puts together our contemporary views on the development, treatment, and prevention of urinary stone disease. We hope that the book helps improve the current care of patients but more importantly highlights areas of potential research and inspires novel approaches that will ease the burden of this disease.

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Impact of citrate therapy on the circadian rhythm of urinary magnesium ammonium phosphate saturation in normal individuals

Cited by 2 publications

References 11 publications

Changes in Urinary Uric Acid Concentration after Dotinurad Administration to Patients with Hyperuricemia: A Post Hoc Analysis of Two Clinical Trials in Japan

Changes in Urinary Uric Acid Concentration after Dotinurad Administration to Patients with Hyperuricemia: A Post Hoc Analysis of Two Clinical Trials in Japan

Urinary Stone Inhibitors

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