Throughout much of the African continent, healthcare systems are already strained in their efforts to meet the needs of a growing population using limited resources. Climate change threatens to undermine many of the public health gains that have been made in this region in the last several decades via multiple mechanisms, including malnutrition secondary to drought-induced food insecurity, mass human displacement from newly uninhabitable areas, exacerbation of environmentally sensitive chronic diseases, and enhanced viability of pathogenic microbes and their vectors. We reviewed the literature describing the various direct and indirect effects of climate change on diseases with cutaneous manifestations in Africa. We included non-communicable diseases such as malignancies (non-melanoma skin cancers), inflammatory dermatoses (i.e. photosensitive dermatoses, atopic dermatitis), and trauma (skin injury), as well as communicable diseases and neglected tropical diseases. Physicians should be aware of the ways in which climate change threatens human health in low-and middle-income countries in general, and particularly in countries throughout Africa, the world's lowest-income and second most populous continent.The African continent has the lowest gross domestic product (GDP) per capita and accounts for less than 4% of global greenhouse gas emissions. 2 In sub-Saharan Africa (SSA), where the socioeconomic conditions are strongly linked to the climatic conditions, loss of healthy life years as a result of climate change is predicted to be up to 500 times greater than in Europe. 3 By 2020, 85-250 million Africans are projected to experience increased water stress as a result of climate change, and crop yields from rain-fed agriculture may decrease by up to 50%. 4 Since 30-40% of Africa's GDP and about three quarters of its population rely on agricultural production as a primary income source, the economic consequences of this could be devastating. 2Given that most of the continent is in the tropical climate zone, sea level rise is expected to be higher than average, and there are at least three African coastal cities with populations over 8 million that may be severely affected. 2 According to the World Bank, as of 2019, the combination of erosion, flooding, and pollution have led to losses of over 3.8 billion United States Dollars (USD) annually, or 5.3% of the combined GDP of Benin, Côte d'Ivoire, Senegal, and Togo, four countries along the West African Coast. 5 African nations will be forced to continue their development under these constraints, and at a high cost; the United Nations (U.N.) estimates climate change adaptation costs to Africa of ª