Impact of Clinical Presentation on Early Vascular Healing After Bioresorbable Vascular Scaffold Implantation

Baquet, Moritz; Brenner, Christoph; Wenzler, Maximilian; Eickhoff, Madeleine; Jochheim, David; Brunner, Stefan; Theiß, Hans; Maßberg, Steffen; Guagliumi, Giulio; Mehilli, Julinda

doi:10.1111/joic.12359

Cited by 5 publications

(2 citation statements)

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“…Overall, this might have contributed to the lack of significance with respect to the observation of fractures and malapposed struts between the two groups in the present cohort and may suggest an inferior mechanical performance of BVS in stable lesions despite similar indices. This observation is consistent with the findings of Baquet et al , who analysed 26 consecutive patients with OCT 6–8 weeks after BVS implantation (46% ACS) [ 30 ]. They reported a numerically higher proportion of protruding and malapposed struts in patients with chronic coronary syndrome than in patients with ACS: protruding 1.26% vs. 4.3%; malapposed 0.39% vs. 2.48%, respectively.…”

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confidence: 92%

Clinical presentation does not affect acute mechanical performance of the Novolimus-eluting bioresorbable vascular scaffold as assessed by optical coherence tomography

Boeder

Dörr

Gaderer

et al. 2021

pwki

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Introduction: Initial trials of bioresorbable vascular scaffolds (BVS) have mostly excluded patients presenting with acute coronary syndrome (ACS). However, these patients might benefit from a BVS platform, in particular as they are often younger and have been less frequently treated than patients with chronic disease.Aim: To compare the acute performance of a Novolimus eluting BVS in ACS and non-ACS patients using optical coherence tomography (OCT) in patients presenting with acute or chronic coronary syndrome.Material and methods: The final OCT pullback of 79 patients (34 with ACS, 45 non-ACS) was analysed at 1-mm intervals. The following indices were calculated: mean and minimal area, residual area stenosis, incomplete strut apposition, tissue prolapse, eccentricity index, symmetry index, strut fracture, and edge dissection.Results: OCT showed a minimum lumen area (non-ACS vs. ACS) of 6.2 ±2.1 vs. 5.6 ±1.5 mm 2 (p = 0.21). Mean residual area stenosis was 14.5% vs. 19.5% (p = 0.39). The mean eccentricity index did not differ significantly (0.78 ±0.13 vs. 0.78 ±0.06; p = 0.42). There was a non-significant tendency for more fractures in the non-ACS group (22.2% vs. 5.9%; p = 0.07). Prolapse area was comparable (4.4 ±7.4 mm 2 vs. 5.2 ±10.9 mm 2 ; p = 0.62).Conclusions: This is the first study to investigate the acute mechanical performance of a Novolimus-eluting BVS in patients with different clinical presentations using OCT. We found that clinical presentation did not determine acute mechanical performance as assessed by the final OCT pullback. There was evidence of more mechanical complications in terms of fractures and a higher percentage of incomplete strut apposition in the group of patients with chronic coronary syndrome.

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