Impact of Coenzyme Q10 and Selenium on Seminal Fluid Parameters and Antioxidant Status in Men with Idiopathic Infertility

Alahmar, Ahmed T; Sengupta, Pallav

doi:10.1007/s12011-020-02251-3

Cited by 55 publications

(40 citation statements)

References 43 publications

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“…Furthermore, CoQ 10 supplementation increased the total antioxidant capacity and the glutathione peroxidase levels, with a consequent reduction in ROS levels and in the sperm DNA fragmentation index [ 188 ]. Similar results concerning the amelioration in sperm concentration, motility, and antioxidant status, were also obtained in the third study, in which 35 infertile males with idiopathic oligoasthenozoospermia were administered 200 mg/day of CoQ 10 H 2 [ 189 ]. In two independent studies, the effectiveness of the 200 mg/die dosage of CoQ 10 H 2 was evaluated by performing the administration of the drug in two daily doses of 100 mg each.…”

Section: Antioxidant-based Therapies In the Treatment Of Male Infesupporting

confidence: 68%

Antioxidant-Based Therapies in Male Infertility: Do We Have Sufficient Evidence Supporting Their Effectiveness?

Amorini

Listorti²,

Bilotta³

et al. 2021

Antioxidants

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Under physiological conditions, reactive oxygen species (ROS) play pivotal roles in various processes of human spermatozoa. Indeed, semen requires the intervention of ROS to accomplish different stages of its maturation. However, ROS overproduction is a well-documented phenomenon occurring in the semen of infertile males, potentially causing permanent oxidative damages to a vast number of biological molecules (proteins, nucleic acids, polyunsaturated fatty acids of biological membrane lipids), negatively affecting the functionality and vitality of spermatozoa. ROS overproduction may concomitantly occur to the excess generation of reactive nitrogen species (RNS), leading to oxidative/nitrosative stress and frequently encountered in various human pathologies. Under different conditions of male infertility, very frequently accompanied by morpho-functional anomalies in the sperm analysis, several studies have provided evidence for clear biochemical signs of damages to biomolecules caused by oxidative/nitrosative stress. In the last decades, various studies aimed to verify whether antioxidant-based therapies may be beneficial to treat male infertility have been carried out. This review analyzed the results of the studies published during the last ten years on the administration of low-molecular-weight antioxidants to treat male infertility in order to establish whether there is a sufficient number of data to justify antioxidant administration to infertile males. An analysis of the literature showed that only 30 clinical studies tested the effects of the administration of low-molecular-weight antioxidants (administered as a single antioxidant or as a combination of different antioxidants with the addition of vitamins and/or micronutrients) to infertile males. Of these studies, only 33.3% included pregnancy and/or live birth rates as an outcome measure to determine the effects of the therapy. Of these studies, only 4 were case–control studies, and only 2 of them found improvement of the pregnancy rate in the group of antioxidant-treated patients. Additionally, of the 30 studies considered in this review, only 43.3% were case–control studies, 66.7% enrolled a number of patients higher than 40, and 40% carried out the administration of a single antioxidant. Therefore, it appears that further studies are needed to clearly define the usefulness of antioxidant-based therapies to treat male infertility.

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Section: Antioxidant-based Therapies In the Treatment Of Male Infesupporting

confidence: 68%

Antioxidant-Based Therapies in Male Infertility: Do We Have Sufficient Evidence Supporting Their Effectiveness?

Amorini

Listorti²,

Bilotta³

et al. 2021

Antioxidants

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“…In one of our RCTs, 35 men with idiopathic OAT were treated for 3 months with CoQ10 at the dose of 200 mg/day and 30 patients with 400 mg/day. The results showed greater improvement in semen parameters in men https://doi.org/10.5653/cerm.2020.04175 who took 400 mg/day [38]. In another study of 70 men with idiopathic OAT, we also demonstrated that CoQ10 therapy (200 mg/day) was associated with improved sperm concentration and motility, as well as a reduction in OS markers [38].…”

Section: Effects Of Coq10 On Sperm Parametersmentioning

confidence: 50%

“…In patients with idiopathic OAT, a significant increase in superoxide dismutase, TAC, and catalase activity after CoQ10 treatment has been reported [30]. We demonstrated that CoQ10 treatment (200 mg/day) could reduce or ameliorate OS markers such as ROS, TAC, catalase, superoxide dismutase, and glutathione peroxidase in infertile men with idiopathic OAT [21,38] and idiopathic oligoasthenozoospermia (OA) [30,37]. Overall, these studies have demonstrated beneficial effects of CoQ10 on improving both enzymatic and non-enzymatic antioxidant capacity among men with idiopathic infertility (Table 1).…”

Section: Coq10 Effects On Os Markersmentioning

confidence: 59%

“…There is evidence supporting the protective role of CoQ10 against ROS-induced sperm damage [37,38]. CoQ10 is known to inhibit superoxide production [46], and a strong negative association has been observed between CoQ10 levels and hydrogen peroxide [46].…”

Section: Coq10 Effects On Os Markersmentioning

confidence: 95%

“…Several clinical studies have reported beneficial effects of CoQ10 supplementation on sperm parameters of infertile patients [21,37,38]. In 287 patients with idiopathic oligoasthenoteratozoospermia (OAT), CoQ10 supplementation (600 mg/day) for 12 months significantly increased sperm concentration (+113.7%), sperm progressive motility (+104.8%) and normal sperm morphology (+78.9%) [39].…”

Section: Effects Of Coq10 On Sperm Parametersmentioning

confidence: 99%

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Coenzyme Q10, oxidative stress, and male infertility: A review

Alahmar

Calogero

Rajender

et al. 2021

Clin Exp Reprod Med

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Male infertility has a complex etiopathology, which mostly remains elusive. Although research has claimed that oxidative stress (OS) is the most likely underlying mechanism of idiopathic male infertility, the specific treatment of OS-mediated male infertility requires further investigation. Coenzyme Q10 (CoQ10), a vitamin-like substance, has been found in measurable levels in human semen. It exhibits essential metabolic and antioxidant functions, as well as playing a vital role in mitochondrial bioenergetics. Thus, CoQ10 may be a key player in the maintenance of biological redox balance. CoQ10 concentrations in seminal plasma directly correlate with semen parameters, especially sperm count and sperm motility. Seminal CoQ10 concentrations have been shown to be altered in various male infertility states, such as varicocele, asthenozoospermia, and medical or surgical regimens used to treat male infertility. These observations imply that CoQ10 plays an important physiological role in the maintenance and amelioration of semen quality. The present article thereby aimed to review the possible mechanisms through which CoQ10 plays a role in the regulation of male reproductive function, and to concisely discuss its efficacy as an ameliorative agent in restoring semen parameters in male infertility, as well as its impact on OS markers, sperm DNA fragmentation, pregnancy, and assisted reproductive technology outcomes.

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