Impact of Coffee, Wine, and Chocolate Consumption on Cognitive Outcome and MRI Parameters in Old Age

Haller, Sven; Montandon, Marie‐Louise; Rodriguez, Cristelle; Herrmann, Françoís; Giannakopoulos, Pantéleimon

doi:10.3390/nu10101391

Cited by 46 publications

(63 citation statements)

References 69 publications

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“…Our finding about coffee consumption was partially consistent with the findings from some previous studies [11][12][13]20,51]. A population-based study of 145 community-based older individuals [11] found a positive effect of coffee on cognitive performance. In addition, a recent 30-year follow-up study of 8000 Japanese-American men [12] suggested that coffee intake might protect against Parkinson's disease.…”

Section: Discussionsupporting

confidence: 92%

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Association of Coffee, Decaffeinated Coffee and Caffeine Intake from Coffee with Cognitive Performance in Older Adults: National Health and Nutrition Examination Survey (NHANES) 2011–2014.

et al. 2020

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The aim of this study was to examine the association of coffee, caffeinated coffee, decaffeinated coffee and caffeine intake from coffee with cognitive performance in older adults. we used data from the National Health and Nutrition Examination Survey (NHANES) 2011–2014. Coffee and caffeine intake were obtained through two 24-hour dietary recalls. Cognitive performance was evaluated by the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) test, Animal Fluency test and Digit Symbol Substitution Test (DSST). Binary logistic regression and restricted cubic spline models were applied to evaluate the association of coffee and caffeine intake with cognitive performance. A total of 2513 participants aged 60 years or older were included. In the fully adjusted model, compared to those reporting no coffee consumption, those who reported 266.4–495 (g/day) had a multivariate adjusted odd ratio (OR) with 95% confidence interval (CI) of 0.56(0.35–0.89) for DSST test score, compared to those reporting no caffeinated coffee consumption, those who reported ≥384.8 (g/day) had a multivariate-adjusted OR (95% CI) of 0.68(0.48–0.97) for DSST test score, compared to the lowest quartile of caffeine intake from coffee, the multivariate adjusted OR (95% CI) of the quartile (Q) three was 0.62(0.38–0.98) for the CERAD test score. L-shaped associations were apparent for coffee, caffeinated coffee and caffeine from coffee with the DSST test score and CERAD test score. No significant association was observed between decaffeinated coffee and different dimensions of cognitive performance. Our study suggests that coffee, caffeinated coffee and caffeine from coffee were associated with cognitive performance, while decaffeinated coffee was not associated with cognitive performance.

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Section: Discussionsupporting

confidence: 92%

“…A number of epidemiological studies have demonstrated an association between higher coffee consumption and better cognitive performance [9][10][11][12][13]. Cognitive benefits from coffee consumption were typically attributed to caffeine.…”

Section: Introductionmentioning

confidence: 99%

Association of Coffee, Decaffeinated Coffee and Caffeine Intake from Coffee with Cognitive Performance in Older Adults: National Health and Nutrition Examination Survey (NHANES) 2011–2014.

et al. 2020

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“…They concluded that the risk of dementia was increased in people who abstained from alcohol in midlife or consumed >14 units/week. Furthermore, results from one MRI study [50] showed that wine consumption was related to less white matter lesions and better cerebral blood flow, demonstrating better cognitive function. Stampfer et al [51] published a cohort study examining the association between moderate alcohol intake and cognitive ability in women, concluding that less than one drink per day may be related to a lower risk of cognitive impairment.…”

Section: Evidence From Epidemiological Studiesmentioning

confidence: 99%

Role of Alcohol Drinking in Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis

Peng

Yang²,

Joshi

et al. 2020

IJMS

103

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Neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS), increase as the population ages around the world. Environmental factors also play an important role in most cases. Alcohol consumption exists extensively and it acts as one of the environmental factors that promotes these neurodegenerative diseases. The brain is a major target for the actions of alcohol, and heavy alcohol consumption has long been associated with brain damage. Chronic alcohol intake leads to elevated glutamate-induced excitotoxicity, oxidative stress and permanent neuronal damage associated with malnutrition. The relationship and contributing mechanisms of alcohol with these three diseases are different. Epidemiological studies have reported a reduction in the prevalence of Alzheimer’s disease in individuals who drink low amounts of alcohol; low or moderate concentrations of ethanol protect against β-amyloid (Aβ) toxicity in hippocampal neurons; and excessive amounts of ethanol increase accumulation of Aβ and Tau phosphorylation. Alcohol has been suggested to be either protective of, or not associated with, PD. However, experimental animal studies indicate that chronic heavy alcohol consumption may have dopamine neurotoxic effects through the induction of Cytochrome P450 2E1 (CYP2E1) and an increase in the amount of α-Synuclein (αSYN) relevant to PD. The findings on the association between alcohol consumption and ALS are inconsistent; a recent population-based study suggests that alcohol drinking seems to not influence the risk of developing ALS. Additional research is needed to clarify the potential etiological involvement of alcohol intake in causing or resulting in major neurodegenerative diseases, which will eventually lead to potential therapeutics against these alcoholic neurodegenerative diseases.

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“…This positive association between the regular intake of moderate doses of coffee and the increased longevity and health quality with ageing is tightly related to the ability of coffee intake to decrease the risk of developing major age-releated chronic disorders, such as diabetes [ 175 , 176 , 177 , 178 , 179 , 180 ], cardiovascular diseases [ 150 , 181 , 182 , 183 , 184 , 185 , 186 , 187 , 188 ], stroke [ 189 , 190 , 191 , 192 ], depression and suicide [ 193 , 194 , 195 , 196 , 197 , 198 , 199 , 200 , 201 ], cognitive decline [ 202 , 203 , 204 , 205 , 206 , 207 ], and neurodegenerativce diseases, such as Alzheimer’s disease [ 208 , 209 , 210 , 211 , 212 ] and Parkinson’s disease [ 213 , 214 , 215 , 216 , 217 , 218 ].…”

Section: Other General Beneficial Health Effects Of Coffeementioning

confidence: 99%

The Coffee–Acrylamide Apparent Paradox: An Example of Why the Health Impact of a Specific Compound in a Complex Mixture Should Not Be Evaluated in Isolation

Nehlig

Cunha

2020

Nutrients

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The health implications of acrylamide in food are a matter of concern based on toxicological studies in rodents, which showed that doses of acrylamide more than 100 times higher than those estimated to result from dietary exposure in humans are carcinogenic; however, the cancer types reported in rodents are species-specific, and whether these results can be extrapolated to humans is still in question. In fact, human epidemiological studies revealed a general lack of association between dietary acrylamide exposure and the incidence of different cancer types. Even occupational exposure to acrylamide, resulting in acrylamide exposure nearly 10 times higher than dietary exposure, did not increase tumor occurrence. Furthermore, the consumption of coffee, which is a main contributor of dietary acrylamide exposure, actually decreases the overall incidence of cancer in humans and afford global health benefits, increasing both lifespan and healthspan on ageing. This paradox clearly illustrates the risk of evaluating an individual molecule independently of its complete food matrix, which may have other components that completely override the effects of the considered molecule.

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Impact of Coffee, Wine, and Chocolate Consumption on Cognitive Outcome and MRI Parameters in Old Age

Cited by 46 publications

References 69 publications

Association of Coffee, Decaffeinated Coffee and Caffeine Intake from Coffee with Cognitive Performance in Older Adults: National Health and Nutrition Examination Survey (NHANES) 2011–2014.

Association of Coffee, Decaffeinated Coffee and Caffeine Intake from Coffee with Cognitive Performance in Older Adults: National Health and Nutrition Examination Survey (NHANES) 2011–2014.

Role of Alcohol Drinking in Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis

The Coffee–Acrylamide Apparent Paradox: An Example of Why the Health Impact of a Specific Compound in a Complex Mixture Should Not Be Evaluated in Isolation

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