Impact of combined consumption of fish oil and probiotics on the serum metabolome in pregnant women with overweight or obesity

Mokkala, Kati; Vahlberg, Tero; Houttu, Noora; Koivuniemi, Ella; Lahti, Leo; Laitinen, Kirsi

doi:10.1016/j.ebiom.2021.103655

Cited by 12 publications

(12 citation statements)

References 39 publications

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“…In the linear model comparing co-abundant groups of metabolites between the women with and without prediabetes, age, pre-pregnancy BMI and intake of polyunsaturated fatty acids (PUFAs) were chosen as covariates because these differed significantly between the study groups in early pregnancy. The dietary intervention during pregnancy was chosen as a covariate based on prior results (Mokkala et al, 2021 ). Model 1 included the following covariates: age, intake of PUFAs and the intervention with model 2 including also pre-pregnancy BMI since we wanted to be able to examine metabolites which correlated strongly with BMI.…”

Section: Methodsmentioning

confidence: 99%

Aberrations in the early pregnancy serum metabolic profile in women with prediabetes at two years postpartum

et al. 2023

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Introduction Aberrations in circulating metabolites have been associated with diabetes and cardiovascular risk. Objectives To investigate if early and late pregnancy serum metabolomic profiles differ in women who develop prediabetes by two years postpartum compared to those who remain normoglycemic. Methods An NMR metabolomics platform was used to measure 228 serum metabolite variables from women with pre-pregnancy overweight in early and late pregnancy. Co-abundant groups of metabolites were compared between the women who were (n = 40) or were not (n = 138) prediabetic at two years postpartum. Random Forests classifiers, based on the metabolic profiles, were used to predict the prediabetes status, and correlations of the metabolites to glycemic traits (fasting glucose and insulin, HOMA2-IR and HbA1c) and hsCRP at postpartum were evaluated. Results Women with prediabetes had higher concentrations of small HDL particles, total lipids in small HDL, phospholipids in small HDL and free cholesterol in small HDL in early pregnancy (p = 0.029; adj with pre-pregnancy BMI p = 0.094). The small HDL related metabolites also correlated positively with markers of insulin resistance at postpartum. Similar associations were not detected for metabolites in late pregnancy. A Random Forests classifier based on serum metabolites and clinical variables in early pregnancy displayed an acceptable predictive power for the prediabetes status at postpartum (AUROC 0.668). Conclusion Elevated serum concentrations of small HDL particles in early pregnancy associate with prediabetes and insulin resistance at two years postpartum. The serum metabolic profile during pregnancy might be used to identify women at increased risk for type 2 diabetes.

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Section: Methodsmentioning

confidence: 99%

Aberrations in the early pregnancy serum metabolic profile in women with prediabetes at two years postpartum

et al. 2023

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“…The stratified randomization was performed with 4 random permuted blocks, and a statistician (not involved in recruitment or study execution) generated randomization lists of the 3 blocks. Altogether, 88.4% women reported good compliance with the intervention ( 17 ). These supplements were selected based on the previous scientific knowledge.…”

Section: Methodsmentioning

confidence: 99%

“…However, not all studies have found associations between these supplements and child's growth, weight, or body composition (14)(15)(16). Fish oil and probiotics potentially have co-effects on maternal metabolism (17), but this view has not been yet studied with regards to child's growth. We hypothesized that fish oil and/or probiotics supplementation during pregnancy is beneficial for the child's growth through their effects in regulating low-grade inflammation and insulin metabolism (18)(19)(20)(21).…”

Section: What Is Newmentioning

confidence: 99%

Fish Oil And/Or Probiotics Intervention in Overweight/Obese Pregnant Women and Overweight Risk in 24-Month-Old Children

Saros

Vahlberg

Koivuniemi

et al. 2022

Journal of Pediatric Gastroenterology &Amp; Nutrition

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Objectives: To evaluate whether a fish oil and/or probiotics intervention in pregnant women with overweight or obesity would influence the tendency of their 24-month-old children to become overweight and alter their body fat percentage. Methods: Women (n = 439) were double-blindly randomized into 4 intervention groups: fish oil+placebo, probiotics+placebo, probiotics+fish oil, and placebo+placebo (fish oil: 1.9 g docosahexaenoic acid and 0.22 g eicosapentaenoic acid, probiotics: Lacticaseibacillus rhamnosus HN001 and Bifidobacterium animalis ssp. lactis 420, 10 10 colony-forming units each). The intervention lasted from early pregnancy until 6 months postpartum. Children's (n = 330) growth data (height, weight, head circumference), a secondary outcome of the trial, were evaluated at birth, 3, 6, 12, and 24 months of age and compared to Finnish growth charts. Body fat percentage was measured with air displacement plethysmography (24 months). Logistic regression and general linear models were used to analyze the data. Results: Probiotics+placebo [weight-for-height% adj. Odds ratio (OR) = 0.36, 95% confidence interval (CI) = 0.14-0.95] and probiotics+fish oil [weight-for-age standard deviation score (SD-score) adj. OR = 0.22, 95% CI = 0.07-0.71] associated with lower overweight odds in 24-monthold children compared to placebo+placebo. Results remained essentially the same, when probiotics' main effect (combined probiotics+placebo and probiotics+fish oil) was estimated; that is, lower overweight odds (weightfor-height% adj. OR = 0.48, 95% CI = 0.25-0.95 and weight-for-age SDscore adj. OR = 0.42, 95% CI = 0.20-0.88) compared to non-probiotics. No fish oil main effect (combined fish oil+placebo and probiotics+fish oil) was seen. The intervention did not influence body fat percentage. Conclusions: The administration of probiotics solely and in combination with fish oil during pregnancy to women with overweight or obesity lowered the overweight odds of their 24-month-old children.

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“…21,22 The serum metabolome is also used to estimate the impact of probiotics on the host's physiological changes. 23,24 Germ-free (GF) animals are cultivated in a sterile isolator without any bacteria, which is suitable for studying the relationship between the host's physiological and pathological development and microorganisms. 25,26 GF animals are effective experimental models to evaluate the influence of probiotic strains on the host directly without the influence of the gut microbiome.…”

Section: Introductionmentioning

confidence: 99%

“…21,22 The serum metabolome is also used to estimate the impact of probiotics on the host's physiological changes. 23,24…”

Section: Introductionmentioning

confidence: 99%

Integrative analysis of the metabolome and transcriptome reveals the influence of Lactobacillus plantarum CCFM8610 on germ-free mice

Huang

et al. 2023

Food Funct.

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Impact of combined consumption of fish oil and probiotics on the serum metabolome in pregnant women with overweight or obesity

Cited by 12 publications

References 39 publications

Aberrations in the early pregnancy serum metabolic profile in women with prediabetes at two years postpartum

Aberrations in the early pregnancy serum metabolic profile in women with prediabetes at two years postpartum

Fish Oil And/Or Probiotics Intervention in Overweight/Obese Pregnant Women and Overweight Risk in 24-Month-Old Children

Integrative analysis of the metabolome and transcriptome reveals the influence of Lactobacillus plantarum CCFM8610 on germ-free mice

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