Impact of Comorbidities on Outcome in Children With COVID-19 at a Tertiary Care Pediatric Hospital

Kapoor, Dipti; Kumar, Virendra; Pemde, Harish; Singh, Preeti

doi:10.1007/s13312-021-2244-0

Cited by 17 publications

(20 citation statements)

References 12 publications

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“…One (2.3%) study did not specify the inclusion criteria [ 46 ]. Only two (4.7%) studies specifically evaluated children [ 63 , 71 ]; others included only adults or described a mixed population. Patient information was retrieved mainly from medical records at participating healthcare facilities, or from surveillance registries or insurance databases ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…Seventeen studies with 42,321 COVID-19 patients, of whom 632 (1.5%) had tuberculosis, reported on deaths due to COVID-19 [ 36 , 39 , 41 – 43 , 45 , 47 – 50 , 52 , 57 , 60 , 63 , 65 – 67 ]. All studies were conducted in high tuberculosis burden countries, except one from South Korea and another that combined data from multiple nations [ 42 , 43 ].…”

Section: Resultsmentioning

confidence: 99%

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Active pulmonary tuberculosis and coronavirus disease 2019: A systematic review and meta-analysis

et al. 2021

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Objective The proportion of COVID-19 patients having active pulmonary tuberculosis, and its impact on COVID-19 related patient outcomes, is not clear. We conducted this systematic review to evaluate the proportion of patients with active pulmonary tuberculosis among COVID-19 patients, and to assess if comorbid pulmonary tuberculosis worsens clinical outcomes in these patients. Methods We queried the PubMed and Embase databases for studies providing data on (a) proportion of COVID-19 patients with active pulmonary tuberculosis or (b) severe disease, hospitalization, or mortality among COVID-19 patients with and without active pulmonary tuberculosis. We calculated the proportion of tuberculosis patients, and the relative risk (RR) for each reported outcome of interest. We used random-effects models to summarize our data. Results We retrieved 3,375 citations, and included 43 studies, in our review. The pooled estimate for proportion of active pulmonary tuberculosis was 1.07% (95% CI 0.81%-1.36%). COVID-19 patients with tuberculosis had a higher risk of mortality (summary RR 1.93, 95% CI 1.56–2.39, from 17 studies) and for severe COVID-19 disease (summary RR 1.46, 95% CI 1.05–2.02, from 20 studies), but not for hospitalization (summary RR 1.86, 95% CI 0.91–3.81, from four studies), as compared to COVID-19 patients without tuberculosis. Conclusion Active pulmonary tuberculosis is relatively common among COVID-19 patients and increases the risk of severe COVID-19 and COVID-19-related mortality.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Active pulmonary tuberculosis and coronavirus disease 2019: A systematic review and meta-analysis

et al. 2021

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“…In another study from our institute Kapoor, et al . [ 8 ], reported a prevalence of 9.27% SARS-CoV-2 positivity in cases admitted in paediatric medicine wards.…”

Section: Discussionmentioning

confidence: 99%

“…These data are similar to that reported by Kapoor, et al . [ 8 ] from our institute, where they had observed that the presence of a comorbid illness in paediatric inpatients with SARS-CoV-2 infection did not impact the illness severity, length of hospitalization, ventilation requirement and mortality.…”

Section: Discussionmentioning

confidence: 99%

Magnitude of SARS-CoV-2 Infection and Outcome in Paediatric Surgical Inpatients during the First Wave of Pandemic at a Tertiary Care Children’s Hospital in India

Prajapati

Choudhury

Aditya

et al. 2022

Journal of Tropical Pediatrics

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Summary This study was conducted at a tertiary care centre of Delhi, to assess the magnitude of SARS-CoV-2 disease and outcome in pediatric surgical inpatients. All the admitted patients were evaluated excluding outpatients and minor procedures. Out of 312 operated patients 2.88% patients were SARS-CoV-2 positive and out of 167 non operative patients 6.58% were SARS-CoV-2 positive. These patients received standard care as per guidelines using standard protective measures and were discharged home. Only one death occurred due to perforation peritonitis with sepsis. The overall prevalence of SARS-CoV-2 in pediatric surgical patients was 4.17% and SARS-CoV-2 positive patients had similar outcomes as compared to non SARS-CoV-2 patients.

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“…23 Penelitian kami menunjukkan bahwa derajat berat-kritis didominasi oleh pasien dengan komorbid, meskipun begitu berdasarkan analisis tidak didapatkan hubungan bermakna. Hal ini selaras dengan penelitian Kapoor dkk 24 yang melaporkan tidak ada perbedaan antara derajat keparahan COVID-19 pada anak dengan komorbid dan tanpa komorbid.…”

Section: Pembahasanunclassified

Studi Deskriptif dan Analitik COVID-19 pada Anak di Rumah Sakit Umum Daerah Ulin Banjarmasin

Hartoyo

Ariyani

Fitri

et al. 2022

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Latar belakang. Penyakit infeksi COVID-19 adalah penyakit kegawatan disebabkan oleh SARS-CoV-2. Hingga saat ini, data COVID-19 anak masih terbatas. Tujuan. Mengetahui gambaran klinis, laboratorium, dan tatalaksana COVID-19 anak serta hubungan antara karakteristik demografi dengan derajat keparahan.Metode. Penelitian retrospektif dengan metode observasional deskriptif digunakan pada gambaran klinis, laboratorium, dan tatalaksana. Metode observasional analitik melalui studi kohort retrospektif untuk menganalisis hubungan antara karakteristik pasien terhadap derajat keparahan. Seluruh pasien anak usia 0-18 tahun terkonfirmasi positif RT-PCR dan memiliki data rekam medis lengkap dan tercatat di RSUD Ulin Banjarmasin periode April 2020-April 2021 diikutsertakan dalam penelitian. Analisis statistik digunakan uji chi-square atau Fisher’s exact (tingkat kepercayaan 95%) dengan menggunakan SPSS for Windows versi 25.0.Hasil. Dari 32 pasien yang diteliti sebagian besar berusia 0-5 tahun (44%), mayoritas perempuan (56%), sebagian besar memiliki komorbid (69%), dan status gizi anak mayoritas baik (61%). Berdasarkan parameter karakteristik hanya usia yang ditemukan memiliki pengaruh terhadap derajat keparahan. Gambaran klinis paling umum adalah demam dan pneumonia (44%). Hasil laboratorium menunjukan adanya peningkatan D-dimer, anemia, dan peningkatan LDH. Terapi yang diberikan sesuai pedoman mencakup terapi utama dan suportif. Kesimpulan. Gejala klinis COVID-19 bervariasi. Hasil laboratorium sebagian besar normal kecuali beberapa parameter. Tatalaksana dilakukan sesuai pedoman. Tidak ada hubungan signifikan pada jenis kelamin, komorbid, dan status gizi.

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Impact of Comorbidities on Outcome in Children With COVID-19 at a Tertiary Care Pediatric Hospital

Cited by 17 publications

References 12 publications

Active pulmonary tuberculosis and coronavirus disease 2019: A systematic review and meta-analysis

Active pulmonary tuberculosis and coronavirus disease 2019: A systematic review and meta-analysis

Magnitude of SARS-CoV-2 Infection and Outcome in Paediatric Surgical Inpatients during the First Wave of Pandemic at a Tertiary Care Children’s Hospital in India

Studi Deskriptif dan Analitik COVID-19 pada Anak di Rumah Sakit Umum Daerah Ulin Banjarmasin

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