Impact of composite scaffold degradation rate on neural stem cell persistence in the glioblastoma surgical resection cavity

Moore, Kathryn M.; Graham-Gurysh, Elizabeth G.; Bomba, Hunter N.; Murthy, Ananya B.; Bachelder, Eric M.; Hingtgen, Shawn

doi:10.1016/j.msec.2020.110846

Cited by 8 publications

(18 citation statements)

References 49 publications

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“…Another key factor in the success of iNSCs is the in vivo persistence of this drug delivery vehicle, as increased persistence can significantly extend the time of cytotoxic payload production and release, thereby improving therapeutic efficacy ( 23 , 34 , 35 ). As potential personalized therapies, hiNeuroS and hiNSC would reduce the need of immunosuppressive drugs, which are typically used for allogeneic transplants to extend the persistence of the cells in a patient ( 36 ).…”

Section: Discussionmentioning

confidence: 99%

“…In the past two decades, numerous studies have proved the effectiveness of using NSCs as drug delivery system to combat primary and secondary brain tumors (10,17,18,(22)(23)(24)(25)(26)(27). While endogenous "off-the-shelf" NSCs and NSCs created by cellular reprogramming are the major two cell sources, the latter has therapeutic advantages because it opens up the possibility for personalized iNSCs transdifferentiated from a patient's own cells, allowing for potentially reduced immunogenicity and increased persistence (11,14).…”

Section: Discussionmentioning

confidence: 99%

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Development of next-generation tumor-homing induced neural stem cells to enhance treatment of metastatic cancers

et al. 2021

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Engineered tumor-homing neural stem cells (NSCs) have shown promise in treating cancer. Recently, we transdifferentiated skin fibroblasts into human-induced NSCs (hiNSC) as personalized NSC drug carriers. Here, using a SOX2 and spheroidal culture-based reprogramming strategy, we generated a new hiNSC variant, hiNeuroS, that was genetically distinct from fibroblasts and first-generation hiNSCs and had significantly enhanced tumor-homing and antitumor properties. In vitro, hiNeuroSs demonstrated superior migration to human triple-negative breast cancer (TNBC) cells and in vivo rapidly homed to TNBC tumor foci following intracerebroventricular (ICV) infusion. In TNBC parenchymal metastasis models, ICV infusion of hiNeuroSs secreting the proapoptotic agent TRAIL (hiNeuroS-TRAIL) significantly reduced tumor burden and extended median survival. In models of TNBC leptomeningeal carcinomatosis, ICV dosing of hiNeuroS-TRAIL therapy significantly delayed the onset of tumor formation and extended survival when administered as a prophylactic treatment, as well as reduced tumor volume while prolonging survival when delivered as established tumor therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Development of next-generation tumor-homing induced neural stem cells to enhance treatment of metastatic cancers

et al. 2021

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“…In a mouse model, GEM-NSCs significantly reduced the residual tumor volume. Moore et al (2020) designed composite gelatin-electrospun scaffolds with two degradation profiles due to different ratios of cyclic to acyclic acetals (fast and slow). NSC implantation efficiency, persistence, and long-term survival were all improved by the fast and slow degrading scaffolds, respectively, and scaffold degradation had little effect on the persistence of NSCs.…”

Section: Stem Cells (Scs)mentioning

confidence: 99%

Technological Advances of 3D Scaffold-Based Stem Cell/Exosome Therapy in Tissues and Organs

Feng

Waqas

et al. 2021

Front. Cell Dev. Biol.

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“…Several studies suggested that scaffolds could boost stem cell proliferation in the brain tissue, thus extending their persistence. Among those natural biomaterial scaffolds that have been well studied are collagen, gelatin, [ 168 ] and hyaluronic acid [ 169 ]. As well, fibrin was studied to enhance the retention of tumoricidal SCs due to its capability to polymerize into a fibrous network [ 170 ].…”

Section: Future Perspectivesmentioning

confidence: 99%

“…As well, fibrin was studied to enhance the retention of tumoricidal SCs due to its capability to polymerize into a fibrous network [ 170 ]. Similarly, the electrospun nanofibrous scaffolds increased the efficacy of stem cell-mediated therapy of surgically resected GB [ 169 , 171 ]. Interestingly, the reported effect was not significantly affected by the scaffold’s degradation rate.…”

Section: Future Perspectivesmentioning

confidence: 99%

Cell-Based Therapy for the Treatment of Glioblastoma: An Update from Preclinical to Clinical Studies

Attia

Mashal

Pemminati

et al. 2021

Cells

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Glioblastoma (GB), an aggressive primary tumor of the central nervous system, represents about 60% of all adult primary brain tumors. It is notorious for its extremely low (~5%) 5-year survival rate which signals the unsatisfactory results of the standard protocol for GB therapy. This issue has become, over time, the impetus for the discipline of bringing novel therapeutics to the surface and challenging them so they can be improved. The cell-based approach in treating GB found its way to clinical trials thanks to a marvelous number of preclinical studies that probed various types of cells aiming to combat GB and increase the survival rate. In this review, we aimed to summarize and discuss the up-to-date preclinical studies that utilized stem cells or immune cells to treat GB. Likewise, we tried to summarize the most recent clinical trials using both cell categories to treat or prevent recurrence of GB in patients. As with any other therapeutics, cell-based therapy in GB is still hampered by many drawbacks. Therefore, we highlighted several novel techniques, such as the use of biomaterials, scaffolds, nanoparticles, or cells in the 3D context that may depict a promising future when combined with the cell-based approach.

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Impact of composite scaffold degradation rate on neural stem cell persistence in the glioblastoma surgical resection cavity

Cited by 8 publications

References 49 publications

Development of next-generation tumor-homing induced neural stem cells to enhance treatment of metastatic cancers

Development of next-generation tumor-homing induced neural stem cells to enhance treatment of metastatic cancers

Technological Advances of 3D Scaffold-Based Stem Cell/Exosome Therapy in Tissues and Organs

Cell-Based Therapy for the Treatment of Glioblastoma: An Update from Preclinical to Clinical Studies

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