2018
DOI: 10.1016/j.joco.2018.02.001
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Impact of correct anatomical slab segmentation on foveal avascular zone measurements by optical coherence tomography angiography in healthy adults

Abstract: PurposeTo evaluate the impact of correct anatomical slab segmentation on foveal avascular zone (FAZ) dimensions in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) using optical coherence tomography angiography (OCTA).MethodsParticipants with healthy retinas were recruited, and 5 × 5 mm OCTA images were acquired using the Canon HS-100 Angio eXpert module. FAZ size was measured in automatically (AS, manufacturer-based) and manually (MS, anatomical-based) segmented OCTA slabs by two experie… Show more

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Cited by 39 publications
(43 citation statements)
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References 23 publications
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“…Interstudy differences in the retinal segmentation presets among OCT-A imaging systems and the lack of correction for the differences in segmentation boundaries can cause significant errors in OCT-A measurements. 29 In addition, OCT-A scanning has artifact-related limitations caused by the projection of superficial vasculature on the deep retinal and choroidal plexuses. 30 Therefore, unlike the superficial retinal layer, accurate information related to the deep retinal layer is difficult to obtain on screening or diagnosis of DR. 16 In this study, we adjusted the anatomic slab segmentation, applied a projection-removal process on every deep vascular plexus image, and included the entire 6 × 6-mm 2 macular area in the microvasculature analysis.…”
Section: Discussionmentioning
confidence: 99%
“…Interstudy differences in the retinal segmentation presets among OCT-A imaging systems and the lack of correction for the differences in segmentation boundaries can cause significant errors in OCT-A measurements. 29 In addition, OCT-A scanning has artifact-related limitations caused by the projection of superficial vasculature on the deep retinal and choroidal plexuses. 30 Therefore, unlike the superficial retinal layer, accurate information related to the deep retinal layer is difficult to obtain on screening or diagnosis of DR. 16 In this study, we adjusted the anatomic slab segmentation, applied a projection-removal process on every deep vascular plexus image, and included the entire 6 × 6-mm 2 macular area in the microvasculature analysis.…”
Section: Discussionmentioning
confidence: 99%
“…OCTA generates slab‐segmented, high‐quality, angiographic images, based on motion contrast of erythrocytes across a stationary background (Rommel et al. ). By now, various OCTA‐based studies exist, which evaluate the microcirculation of the choriocapillaris (CC) in healthy and diseased subjects (Qu et al.…”
Section: Introductionmentioning
confidence: 99%
“…However, the use of FA is quite laborious because it is an invasive procedure that takes time and needs an experienced ophthalmologist to review the resulting images carefully. Recently, optical coherence tomography angiography (OCTA) has been introduced, which generates angiographic images based on motion contrast imaging to high-resolution volumetric blood flow information in a few seconds 5. OCTA is a non-invasive technique, which allows the quantification of perfused and non-perfused areas of the retina in primarily ocular pathologies, but it also mirrors vascular involvement in systemic diseases as most recently shown for systemic lupus erythematosus 6.…”
mentioning
confidence: 99%