Impact of COVID-19 on Screening Rates for Colorectal, Breast, and Cervical Cancer: Practice Feedback From a Quality Improvement Project in Primary Care

Schad, Laura A; Brady, Laura; Tumiel-Berhalter, Laurene; Bentham, Alexandrea; Vitale, Karen; Norton, Amanda; Noronha, Gary; Swanger, Carlos; Morley, Christopher P.

doi:10.17294/2330-0698.1856

Cited by 12 publications

(19 citation statements)

References 8 publications

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“…Colonoscopy was the only screening test that had a significant decrease during the pandemic year, possibly due to patient or provider reluctance to obtain this test, as it is an invasive procedure that requires preparation. Our findings align with other studies, which showed a decrease in colorectal screening in 2020 and more focally from March to June 2020 16–20. Of note, screening CTs for lung cancers is the newest of these screening modalities.…”

Section: Discussionsupporting

confidence: 92%

“…There was also no significant difference seen in Q1 [14.33 (SEM2.028) vs. 16.17(SEM1.079), P = 0.457], Q3 [16.00 (SEM2.000) vs. 14.08 (SEM1.131), P = 0.455], or Q4 [13.67 (SEM0.8819) vs. 17.17 (SEM1.302), P = 0.218]. There were fewer new colorectal cancer diagnoses than in Q2 of 2020 versus 2016-2019 [9.667 (SEM3.283) vs. 16.50 (SEM1.317), P = 0.044; Fig. 2D].…”

Section: Volume Of Screening Testsmentioning

confidence: 99%

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The Early Impact of the COVID-19 Pandemic on Lung, Colorectal, and Breast Cancer Screening and Treatment at a Tertiary Cancer Center

Lou

Kooragayala

Williams

et al. 2022

American Journal of Clinical Oncology

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Objectives: During the coronavirus-19 pandemic, experts recommended delaying routine cancer screening and modifying treatment strategies. We sought to understand the sequalae of these recommendations. Materials and Methods: We performed a retrospective single-center analysis of screening, diagnosis, and treatment of lung, colorectal, and breast cancer. Data was collected from our institutional cancer registry. Prepandemic (2016-2019) was compared with pandemic (2020) data. Results: Three thousand three sixty one screening chest computed tomography scans (CTs), 35,917 colonoscopies, and 48,093 screening mammograms were performed. There was no difference in CTs [81.0 (SEM10.0) vs. 65.6 (SEM3.29), P =0.067] or mammograms [1017.0 (SEM171.8) vs. 809.4 (SEM56.41), P =0.177] in 2020 versus prepandemic. There were fewer colonoscopies in 2020 [651.4 (SEM103.5) vs. 758.91 (SEM11.79), P =0.043]. There was a decrease in cancer diagnoses per month in 2020 of lung [22.70 (SEM1.469) vs. 28.75 (SEM0.8216), P =0.003] and breast [38.56 (SEM6.133) vs. 51.82 (SEM1.257), P =0.001], but not colorectal [13.11 (SEM1.467) vs. 15.88 (SEM0.585), P =0.074] cancer. There was no change in stage at presentation for lung ( P =0.717), breast ( P =0.115), or colorectal cancer ( P =0.180). Lung had a shorter time-to-treatment in 2020 [38.92 days (SEM 2.48) vs. 66 (SEM1.46), P =0.002]. Conclusions: In 2020, there was no difference in screening studies for lung and breast cancer but there was a decrease in new diagnoses. Although there were fewer colonoscopies performed in 2020, there was no change in new colorectal cancer diagnoses. Despite changes in guidelines during the pandemic, the time-to-treatment for lung cancer was shorter and was unchanged for colorectal and breast cancer. These findings highlight the importance of continuing care for a vulnerable patient population despite a pandemic.

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Section: Discussionsupporting

confidence: 92%

Section: Volume Of Screening Testsmentioning

confidence: 99%

The Early Impact of the COVID-19 Pandemic on Lung, Colorectal, and Breast Cancer Screening and Treatment at a Tertiary Cancer Center

Lou

Kooragayala

Williams

et al. 2022

American Journal of Clinical Oncology

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“…Third, beyond the impact of COVID-19, the changes in people's behavioral patterns globally cannot be ignored [56]. The global COVID-19 pandemic has not only had an imminent impact on routine medical care, including surgery, radiotherapy, and chemotherapy, but has also altered the cancer screening rates, thereby leading to poor early-stage cancer detection [57][58][59]. The pandemic eventually resulted in a sustained decrease in the number of people referred, diagnosed, and treated for cancer [59].…”

Section: Discussionmentioning

confidence: 99%

m6 RNA methylation: an emerging common target in the immune response to cancer and severe acute respiratory syndrome-coronavirus-2 infection

Sato

Hara

Otsuka

et al. 2023

Exploration of Medicine

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m6A RNA methylation, a predominant type of RNA modification, is involved in regulating mRNA splicing, stability, and translation as well as the interaction between nucleoproteins and noncoding RNAs. Recent studies have revealed that m6A RNA methylation plays a critical role in the self-to-non-self-recognition of immune cells against endogenous mutations in cancer and exogenous organism-related infections. As an epigenetic mechanism, m6A RNA modification induces immune cell signal transduction, which is altered in the tumor microenvironment, as detected in liquid biopsy. Furthermore, m6A RNA methylation-related inflammation is involved in the cellular response to viral infections, including the emerging severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection. Given the importance of the immune response in maintaining homeostasis in higher eukaryotes, m6A RNA methylation could be useful not only for the early detection of cancer but also for SARS-CoV-2 screening during a global pandemic.

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“…The key findings of the current study are that during the COVID-19 pandemic, screening tests for cervical dysplasia, specifically the Pap and VIAA tests, have been negatively affected. Many recent studies have demonstrated the negative effects of the COVID-19 pandemic on screening tests for cervical dysplasia [7]. These effects has been sufficiently severe that some consider the screening programs for this disease to be in a state of crisis [8][9][10].…”

Section: Discussionmentioning

confidence: 99%

The Effectiveness of Pap and Visual Inspection With Acetic Acid (VIAA) Tests in Cervical Dysplasia Screenings During the COVID-19 Pandemic

Lagos-Castillo¹,

Guevara-Vizcarra²,

Paredes-Campos³

et al. 2022

Cureus

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This study was aimed at analyzing the validity and reliability of the Papanicolaou (Pap) test and visual inspection with acetic acid (VIAA) tests for cervical dysplasia screenings during the COVID-19 pandemic. Material and methodsThis was a retrospective study of patients 21 years or older seen at the Luis Negreiros Primary Care Center in Lima, Peru between 2020 and 2021, who underwent cervical dysplasia screening (Pap or VIAA). Relevant information regarding patient age, date of service, and Pap and VIAA results were collected. Parallel form reliability was analyzed with chi-square tests, and phi, contingency and Cramer's V coefficients. The validity of these tests was analyzed through the calculation of the sensitivity, specificity, and positive and negative predictive values with confidence intervals. A p-value less than 0.05 indicated statistical significance. ResultsFrom 4,503 records, the sensitivity, specificity, and positive and negative predictive values for Pap were 0.87 (0.

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Impact of COVID-19 on Screening Rates for Colorectal, Breast, and Cervical Cancer: Practice Feedback From a Quality Improvement Project in Primary Care

Cited by 12 publications

References 8 publications

The Early Impact of the COVID-19 Pandemic on Lung, Colorectal, and Breast Cancer Screening and Treatment at a Tertiary Cancer Center

The Early Impact of the COVID-19 Pandemic on Lung, Colorectal, and Breast Cancer Screening and Treatment at a Tertiary Cancer Center

m6 RNA methylation: an emerging common target in the immune response to cancer and severe acute respiratory syndrome-coronavirus-2 infection

The Effectiveness of Pap and Visual Inspection With Acetic Acid (VIAA) Tests in Cervical Dysplasia Screenings During the COVID-19 Pandemic

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