Impact of COVID-19 Outbreak on the Gynecological Outpatients HPV Infection Rate in Wuhan, China: A Retrospective Observational Study

Liu, Huan; Ye, Qian; Di, Li; Zhao, Zhiming; Li, Yan

doi:10.3389/fmed.2022.799736

Cited by 5 publications

(5 citation statements)

References 24 publications

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“…Considering that HPV infections may increase rapidly after the pandemic. 28 We recommend the immediate implementation of effective HPV, cervical cancer screening, and HPV vaccine programs to reduce the spread of HPV infections. The global confrontation with COVID-19 has not only diverted current healthcare resources to deal with the infection but has also resulted in increased resources in the areas of testing and screening, as well as educating most of the global public of the benefits of vaccination.…”

Section: Discussionmentioning

confidence: 99%

HPV prevalence and genotype distribution among women in eastern China during the Covid-19 pandemic

Xia

Zheng

et al. 2023

Human Vaccines & Immunotherapeutics

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Since March 2020, the pandemic caused by SARS-CoV-2 has affected nearly all aspects of daily life. In this study, we investigated the age-stratified prevalence and genotype distribution of human papillomavirus (HPV) among females in Shandong province (eastern China) and aimed to provide guidance on HPV-based cervical cancer screening and vaccination. The distribution of HPV genotypes was analyzed using PCR-Reverse Dot Hybridization. The overall infection rate of HPV was 16.4%, which was dominated by high-risk genotypes. The most prevalent genotype was HPV16 (2.9%), followed by HPV52 (2.3%), HPV53 (1.8%), HPV58 (1.5%), and HPV51 (1.3%). Among the positive cases with HPV infection, single-genotype infection was significantly higher than that of multi-genotype infection. In subgroup analyses by age (≤25, 26–35, 36–45, 46–55, >55), HPV16, 52, and 53 were consistently the three most common hrHPV genotypes in all age groups. The infection rate of multi-genotypes in the ≤25 and >55 age groups was significantly higher than that in other age groups. A bimodal distribution of HPV infection rate was observed in different age groups. Among lrHPV genotypes, HPV6, HPV11, and HPV81 were the three most common types in the ≤25 age group, while in other age groups, HPV81, HPV42, and HPV43 are the three most common lrHPV genotypes. This study provides basic information on the distribution and genotypes of HPV in the female population in eastern China, which could improve the application of HPV diagnostic probes and vaccines.

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Section: Discussionmentioning

confidence: 99%

HPV prevalence and genotype distribution among women in eastern China during the Covid-19 pandemic

Xia

Zheng

et al. 2023

Human Vaccines & Immunotherapeutics

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“…[52][53][54] Thus, acknowledging the role of HPV infection in males as a conduit for HPV transmission to females could significantly influence the adoption of preventive measures for cervical health. The overall incidence of HPV infection appeared to have decreased during the pandemic 55 ; however, our study revealed an unexpected trend in which male HPV infection rates remained unaffected by isolation and containment measures. Specifically, our data indicated that the prevalence of HPV infection among males increased from 23.93% in the prepandemic to 25.86% during the pandemic, with both HR-HPV and LR-HPV infections showing the upward trend (HR-HPV: 21.92% vs. 23.64%; LR-HPV: 3.06% vs.…”

Section: Discussionmentioning

confidence: 49%

The impact of the COVID‐19 pandemic on the prevalence and genotype distribution of HPV infection in Beijing, China

Yi,

Li,

Zhang

et al. 2023

Journal of Medical Virology

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Human papillomavirus (HPV) is one of the most common sexually transmitted infections nationwide. The COVID‐19 pandemic has greatly influenced on the HPV prevention project. The objective of this study was to examine the influence of the pandemic on HPV prevalence and genotype distribution in Beijing, China. A total of 44 401 genital swabs were obtained from outpatients at Peking Union Medical College Hospital during two distinct periods: the prepandemic stage from January 2017 to December 2019 and the pandemic stage from January 2020 to December 2022. During the prepandemic and pandemic stages, a total of 33 531 and 10 870 swabs were respectively collected. Fifteen high‐risk HPV (HR‐HPV) DNA type and a combination of two low‐risk (LR‐HPV) types (6/11) of genital swabs were detected to compare the HPV infection rates and genotype distributions in two stages. The results showed that the pandemic period witnessed a decrease in the overall HPV infection rate from 33.43% (11 245/33 531) to 29.43% (5527/18 780) compared to the prepandemic. There were statistically significant differences in infection rates between females and males (p < 0.05). Single infection was the predominant type while multiple infection was more prevalent in males than females in both prepandemic and pandemic periods. HR‐HPV infection constituted the majority of infections and cannot be disregarded. The distribution of HR‐HPV genotypes exhibited little variation before and after the outbreak, but there were some differences between females and males. HPV 16, 52, 58, 56, and 66 were the most commonly detected genotypes in females, whereas HPV 16, 52, 51, 58, and 18 were frequently detected in males. Additionally, HPV 6/11 exhibited a higher prevalence in males than in females. Notably, the age group of 31−40 years old exhibited the highest prevalence of HPV and the lowest infection rate was detected among individuals aged ≤20 years (p < 0.05), which remained relatively consistent before and during the pandemic. These findings underscore the importance of monitoring the trend of HPV epidemic and offer valuable insights for the prevention, treatment, and scientific investigation of HPV in the post‐COVID‐19 era.

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“…Additionally, nonpharmaceutical interventions for HPV transmission likely led to reduced access to health services, resulting in an elevated risk of undiagnosed HPV [ 31 ]. However, as the pandemic subsides and social activities gradually resume, coupled with reduced vaccination rates during this period [ 32 ], there is a potential surge in HPV infection rates [ 33 ]. Therefore, it is crucial to promptly enhance HPV screening and vaccination strategies to mitigate the potential surge in HPV dissemination.…”

Section: Discussionmentioning

confidence: 99%

“…These genotypes can be categorized into high-risk (HR) and low-risk (LR) types based on their carcinogenic potential. Epidemiological studies and mechanistic evidence have revealed that HPV16, 18,31,33,35,39,45,51,52,56,58, and 59 are carcinogenic, while HPV68 is considered potentially carcinogenic [6]. Currently, HPV vaccination and screening are the primary strategies for preventing cervical cancer.…”

Section: Introductionmentioning

confidence: 99%

The prevalence and genotype distribution of human papillomavirus in central Fujian Province during the COVID-19 pandemic

Lin,

Zhang,

Liu

et al. 2024

Virol J

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Background Global human activities were significantly impacted by the emergence of the coronavirus disease 2019 (COVID-19) pandemic caused by the 2019 novel coronavirus. This study aimed to investigate the prevalence and genotype distribution of HPV infection in Central Fujian Province during the pandemic. Methods Cervical samples were collected from 21,612 outpatients and 12,664 females who underwent physical examinations and HPV screening at the People’s Hospital of Fujian Province in Fuzhou from April 2020 to April 2023. HPV detection and genotyping were conducted using PCR hybridization. Results The overall HPV infection rate was 16.1% during the COVID-19 pandemic, with the outpatient group exhibiting a greater infection rate (19.0%) than did the healthy group (12.3%). The top five high-risk HPV (HR-HPV) genotypes in both groups were HPV52, HPV53, HPV58, HPV16, and HPV51. Additionally, HPV81 and HPV43 were the two most common low-risk HPV (LR-HPV) genotypes in the patient group, while HPV81 and HPV42 were the two most common LR-HPV genotypes in the healthy group. The highest prevalence of HPV infection was observed in individuals aged ≤ 24 years (28.4%, 95% CI 25.9–30.9), followed by those aged ≥ 55 years (23.6%, 95% CI 21.6–24.7) and other age groups. The prevalence decreased from 23.0% (95% CI 22.4–23.7) in 2018–2019 to 13.8% (95% CI 12.0-15.5) in 2023. Conclusion This study provides valuable insights into the prevalence and genotypes of HPV infection in the female population of Central Fujian Province from 2020 to 2023. The findings indicate that the prevalence of HPV infection in Central Fujian Province remains relatively low compared to the national average. Furthermore, the prevalence of HPV decreased during the COVID-19 pandemic; however, as the pandemic waned, there was potential for an increase in HPV infection rates. Therefore, it is crucial to strengthen HPV screening and vaccination strategies to prevent the potential spread of HPV.

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Impact of COVID-19 Outbreak on the Gynecological Outpatients HPV Infection Rate in Wuhan, China: A Retrospective Observational Study

Cited by 5 publications

References 24 publications

HPV prevalence and genotype distribution among women in eastern China during the Covid-19 pandemic

HPV prevalence and genotype distribution among women in eastern China during the Covid-19 pandemic

The impact of the COVID‐19 pandemic on the prevalence and genotype distribution of HPV infection in Beijing, China

The prevalence and genotype distribution of human papillomavirus in central Fujian Province during the COVID-19 pandemic

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