Impact of Cranberry Juice Enriched with Omega-3 Fatty Acids Adjunct with Nonsurgical Periodontal Treatment on Metabolic Control and Periodontal Status in Type 2 Patients with Diabetes with Periodontal Disease

Javid, Ahmad Zare; Maghsoumi‐Norouzabad, Leila; Ashrafzadeh, Elnaz; Yousefimanesh, Hojat allah; Zakerkish, Mehrnoosh; Angali, Kambiz Ahmadi; Ravanbakhsh, Maryam; Babaei, Hossein

doi:10.1080/07315724.2017.1357509

Cited by 34 publications

(49 citation statements)

References 46 publications

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“…CrB extracts (CrBEs) also halted visceral adiposity and weight gain in HFD-fed C57BL/6J mice, and improved HFD-induced hypercholesterolemia, hypertriglyceridemia, antioxidant defense mechanisms, and hepatic oxidative stress and normalized the NF-κB/IκB ratio [ 54 ]. Long-term CrBE consumption effects were also investigated [ 55 , 63 ], and the addition of CrBE to normal chow delayed age-related basal plasma insulin concentration declines [ 63 ]. CrBE supplementation also improved glucose responsiveness and increased insulin concentrations (7.6%) in rats, without significant HOMA-IR changes.…”

Section: Cranberriesmentioning

confidence: 99%

“…Serum HbA1c levels were reduced by 11.4% and 6.02% following RCCJ and RCCJ enriched with omega-3 fatty acid consumption. Omega-3 fatty acid-enriched RCCJ also increased HDL-C levels by 21.1% compared with the baseline [ 63 ]. Additionally, folic acid consumption combined with LCCJ decreased plasma homocysteine levels and increased adiponectin and folic acid levels without any change in inflammatory biomarker levels (IL-6, IL-10, IL-18, and TNF-α) [ 66 ].…”

Section: Cranberriesmentioning

confidence: 99%

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Select Polyphenol-Rich Berry Consumption to Defer or Deter Diabetes and Diabetes-Related Complications

et al. 2020

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Berries are considered “promising functional fruits” due to their distinct and ubiquitous therapeutic contents of anthocyanins, proanthocyanidins, phenolic acids, flavonoids, flavanols, alkaloids, polysaccharides, hydroxycinnamic, ellagic acid derivatives, and organic acids. These polyphenols are part of berries and the human diet, and evidence suggests that their intake is associated with a reduced risk or the reversal of metabolic pathophysiologies related to diabetes, obesity, oxidative stress, inflammation, and hypertension. This work reviewed and summarized both clinical and non-clinical findings that the consumption of berries, berry extracts, purified compounds, juices, jams, jellies, and other berry byproducts aided in the prevention and or otherwise management of type 2 diabetes mellitus (T2DM) and related complications. The integration of berries and berries-derived byproducts into high-carbohydrate (HCD) and high-fat (HFD) diets, also reversed/reduced the HCD/HFD-induced alterations in glucose metabolism-related pathways, and markers of oxidative stress, inflammation, and lipid oxidation in healthy/obese/diabetic subjects. The berry polyphenols also modulate the intestinal microflora ecology by opposing the diabetic and obesity rendered symbolic reduction of Bacteroidetes/Firmicutes ratio, intestinal mucosal barrier dysfunction-restoring bacteria, short-chain fatty acids, and organic acid producing microflora. All studies proposed a number of potential mechanisms of action of respective berry bioactive compounds, although further mechanistic and molecular studies are warranted. The metabolic profiling of each berry is also included to provide up-to-date information regarding the potential anti-oxidative/antidiabetic constituents of each berry.

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Section: Cranberriesmentioning

confidence: 99%

Section: Cranberriesmentioning

confidence: 99%

Select Polyphenol-Rich Berry Consumption to Defer or Deter Diabetes and Diabetes-Related Complications

et al. 2020

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“…Second, after screening the full texts of the remaining 13 articles, four reports were excluded for irrelevant outcome measurement [ 50 ], insufficient inclusion criteria [ 40 , 51 ], and inappropriate study design [ 52 ] ( Table S1 ). Finally, nine eligible reports from eight studies [ 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 ] were included in this systematic review (inter-reviewer agreement, kappa statistic = 0.81). Among the nine reports included, two reports [ 57 , 60 ] had data generated from a single study conducted by Javid et al [ 57 , 60 ].…”

Section: Resultsmentioning

confidence: 99%

Effects of Antioxidant in Adjunct with Periodontal Therapy in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis

et al. 2021

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This review investigated whether the adjunctive use of antioxidants with periodontal therapy improves periodontal parameters in patients with type 2 diabetes. A systematic and extensive literature search for randomized controlled trials (RCTs) conducted before April 2021 was performed on the PubMed, Cochrane Library, and Web of Science databases. The risk of bias was assessed using the Cochrane risk-of-bias tool. A meta-analysis was performed to quantitatively evaluate the clinical outcomes following periodontal therapy. After independent screening of 137 initial records, nine records from eight RCTs were included. The risk-of-bias assessment revealed that all RCTs had methodological weaknesses regarding selective bias, although other risk factors for bias were not evident. This meta-analysis of two RCTs showed that periodontal pocket depths were significantly reduced in the groups treated with combined non-surgical periodontal therapy and melatonin than in those treated with non-surgical periodontal therapy alone. The present systematic review and meta-analysis suggest that the adjunctive use of melatonin, resveratrol, omega-3 fatty acids with cranberry juice, propolis, and aloe vera gel with periodontal therapy significantly improves periodontal disease parameters in patients with type 2 diabetes, and melatonin application combined with non-surgical periodontal therapy might significantly reduce periodontal pocket depth. However, there are still limited studies of melatonin in combination with non-surgical periodontal therapy in Type 2 diabetic patients, and more well-designed RCTs are required to be further investigated.

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“…The beneficial influence of diets enriched in proanthocyanidins from cranberry juice and fish oil on both insulin and lipoprotein metabolisms were also found in patients with diabetes and periodontal disease since this mixture of nutrients decreased glycated hemoglobin and increased HDL-C, while improving periodontal status in those patients [ 59 ]. It was also reported that the postprandial chylomicron response to acute or chronic fish oils plus polyphenols intake is different and even opposite [ 60 ], adding an extra layer in the complex effects of the nutritional intervention with these food compounds.…”

Section: Combined Polyphenols and Fish Oils Intake For Improving Metabolic Healthmentioning

confidence: 99%

Polyphenols and Fish Oils for Improving Metabolic Health: A Revision of the Recent Evidence for Their Combined Nutraceutical Effects

Méndez

Medina

2021

Molecules

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Polyphenols and omega-3 polyunsaturated fatty acids from fish oils, i.e., eicosapentaenoic and docosahexaenoic acids, are well-recognized nutraceuticals, and their single antioxidant and anti-inflammatory properties have been demonstrated in several studies found in the literature. It has been reported that the combination of these nutraceuticals can lead to three-fold increases in glutathione peroxidase activity, two-fold increases in plasma antioxidant capacity, decreases of 50–100% in lipid peroxidation, protein carbonylation, and urinary 8-isoprotanes, as well as 50–200% attenuation of common inflammation biomarkers, among other effects, as compared to their individual capacities. Therefore, the adequate combination of those bioactive food compounds and their single properties should offer a powerful tool for the design of successfully nutritional interventions for the prevention and palliation of a plethora of human metabolic diseases, frequently diet-induced, whose etiology and progression are characterized by redox homeostasis disturbances and a low-grade of chronic inflammation. However, the certain mechanisms behind their biological activities, in vivo interaction (both between them and other food compounds), and their optimal doses and consumption are not well-known yet. Therefore, we review here the recent evidence accumulated during the last decade about the cooperative action between polyphenols and fish oils against diet-related metabolic alterations, focusing on the mechanisms and pathways described and the effects reported. The final objective is to provide useful information for strategies for personalized nutrition based on these nutraceuticals.

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Impact of Cranberry Juice Enriched with Omega-3 Fatty Acids Adjunct with Nonsurgical Periodontal Treatment on Metabolic Control and Periodontal Status in Type 2 Patients with Diabetes with Periodontal Disease

Abstract: Consumption of cranberry juice enriched with omega-3 can be beneficial as adjuvant therapy with nonsurgical periodontal therapy in decreasing glycated hemoglobin, increasing HDL-C, and improving periodontal status in patients with diabetes with periodontal disease.

Cited by 34 publications

References 46 publications

Select Polyphenol-Rich Berry Consumption to Defer or Deter Diabetes and Diabetes-Related Complications

Select Polyphenol-Rich Berry Consumption to Defer or Deter Diabetes and Diabetes-Related Complications

Effects of Antioxidant in Adjunct with Periodontal Therapy in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis

Polyphenols and Fish Oils for Improving Metabolic Health: A Revision of the Recent Evidence for Their Combined Nutraceutical Effects

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