Impact of curcumin loading on the physicochemical, mechanical and antimicrobial properties of a methacrylate-based experimental dental resin

Abstract

Oral biofilms are directly linked to one of the most common chronic human diseases, dental caries. Resin-based dental materials have significant potential to replace amalgam, however they lack sufficient antimicrobial power. This innovative study investigates a curcumin-loaded dental resin which can be utilized in an antimicrobial photodynamic therapy (aPDT) approach. The study evaluated the effects of curcumin loading on resin physicochemical, mechanical, and adhesive properties, as well as the antimicrobial response associated with blue light activation. Preliminary tests involving degree of conversion (DC) and sample integrity determined the optimal loading of curcumin to be restricted to 0.05 and 0.10 wt%. These optimal loadings were tested for flexural strength (FS), water sorption (WS) and solubility (SL), shear bond strength to dentin (SBS), and viability of Streptococcus mutans under 14.6 J/cm2 blue light or dark conditions, in 6 h and 24 h biofilms. The results demonstrated that 0.10 wt% curcumin had minimal impact on either FS or SBS, but detectably increased WS and SL. A 2 log10 (CFU/mL) reduction in S. mutans after light application in both 6 h and 24 h biofilms were corroborated by CLSM imaging and highlighted the significant potential of this novel aPDT approach with resin-based dental materials.

A Systematic Evaluation of Curcumin Concentrations and Blue Light Parameters towards Antimicrobial Photodynamic Therapy against Cariogenic Microorganisms

“…Curcumin has been previously investigated as a PS to mitigate cariogenic microorganisms through PDT [ 16 , 17 , 18 , 19 , 27 , 36 ], mainly in direct contact with the cells in planktonic cultures. However, the parameters utilized in aPDT investigations with curcumin as the photosensitizer are not only inconsistent, but there has been very little investigation of the photochemical reaction and ROS production necessary to generate the desired antimicrobial effect.…”

“…While there are several PSs that have been of interest for aPDT in dentistry, curcumin has garnered significant attention in this field owing in part to its historical use in other medical fields, and its compatible properties for use in aPDT [ 16 ]. Curcumin presents some important advantages, including having a maximum absorption peak in the blue light wavelengths (i.e., 420–450 nm), its low cost, and its effectiveness at targeting several different pathogenic microorganisms, including S. mutans and C. albicans [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. Curcumin is a dye obtained from the root of Curcuma longa and while considered soluble in ethanol and DMSO, it is relatively insoluble in water [ 27 , 28 ].…”

Optical effects of graphene addition on adhesives for orthodontic lingual retainers

“…Following measurement of three samples per group after 24 h of storage at room temperature, the results were averaged. The colour difference, $$\Delta E$$ of each group compared with the control group (0% wt of graphene) was calculated as follows [31]: $$$$\begin{equation}\Delta E\; = {\left[ {{{( {\Delta {L^*}} )}^2} + {{( {\Delta {a^*}} )}^2} + {{( {\Delta {b^*}})}^2}}\right]^{1/2}}\;\end{equation}$$$$where $$\Delta {L^*}$$, $$\Delta {a^*}$$, and $$\Delta {b^*}$$ are the differences in lightness and colour between specimens of each group and control group.…”

“…Following measurement of three samples per group after 24 h of storage at room temperature, the results were averaged. The colour difference, Δ𝐸 of each group compared with the control group (0% wt of graphene) was calculated as follows [31]:…”

Nanocurcumin Release from Self-Cured Acrylic Resins; Effects on Antimicrobial Action and Flexural Strength

“…The outcomes confirmed that 0.10 wt% curcumin had minimal impact on either flexural strength or shear bond strength, but obviously increased water sorption and solubility. It also showed good antimicrobial effects against S. mutans [41].…”