Impact of curcumin on sirtuins: A review

Zendedel, Elham; Butler, Alexandra E.; Atkin, Stephen L.; Sahebkar, Amirhossein

doi:10.1002/jcb.27371

Cited by 51 publications

(38 citation statements)

References 111 publications

(241 reference statements)

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“…In vascular smooth muscle cells, Cur promotes AMPK activation, which enhances superoxide and ATP production. This event stimulates an increase in NAD + levels and SIRT1 activation ( Zendedel et al, 2018 ). Cur-induced SIRT1 upregulation has beneficial effects against a range of diseases including cardiac fibrosis, diabetes, and ischemia/reperfusion injury ( Zendedel et al, 2018 #7; Yang et al, 2013 #5).…”

Section: Natural Compounds Enhancing Sirt1 Expression and Activitymentioning

confidence: 99%

“…This event stimulates an increase in NAD + levels and SIRT1 activation ( Zendedel et al, 2018 ). Cur-induced SIRT1 upregulation has beneficial effects against a range of diseases including cardiac fibrosis, diabetes, and ischemia/reperfusion injury ( Zendedel et al, 2018 #7; Yang et al, 2013 #5). The involvement of mitochondrial oxidative damage in several diseases such as MI/R is well known ( Yang et al, 2013 ).…”

Section: Natural Compounds Enhancing Sirt1 Expression and Activitymentioning

confidence: 99%

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SIRT1 Activation by Natural Phytochemicals: An Overview

et al. 2020

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Sirtuins are class III histone deacetylases, whose enzymatic activity is dependent on NAD + as a cofactor. Sirtuins are reported to modulate numerous activities by controlling gene expression, DNA repair, metabolism, oxidative stress response, mitochondrial function, and biogenesis. Deregulation of their expression and/or action may lead to tissue-specific degenerative events involved in the development of several human pathologies, including cancer, neurodegeneration, and cardiovascular disease. The most studied member of this class of enzymes is sirtuin 1 (SIRT1), whose expression is associated with increasing insulin sensitivity. SIRT1 has been implicated in both tumorigenic and anticancer processes, and is reported to regulate essential metabolic pathways, suggesting that its activation might be beneficial against disorders of the metabolism. Via regulation of p53 deacetylation and modulation of autophagy, SIRT1 is implicated in cellular response to caloric restriction and lifespan extension. In recent years, scientific interest focusing on the identification of SIRT1 modulators has led to the discovery of novel small molecules targeting SIRT1 activity. This review will examine compounds of natural origin recently found to upregulate SIRT1 activity, such as polyphenolic products in fruits, vegetables, and plants including resveratrol, fisetin, quercetin, and curcumin. We will also discuss the potential therapeutic effects of these natural compounds in the prevention and treatment of human disorders, with particular emphasis on their metabolic impact.

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Section: Natural Compounds Enhancing Sirt1 Expression and Activitymentioning

confidence: 99%

Section: Natural Compounds Enhancing Sirt1 Expression and Activitymentioning

confidence: 99%

SIRT1 Activation by Natural Phytochemicals: An Overview

et al. 2020

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“…SIRT1 also activates AMPK through LKB1 deacetylation. In fact, AMPK and SIRT1 create a negative feedback loop by affecting each other's activation (37,38). Therefore, a correlation in their expression is expected.…”

Section: Discussionmentioning

confidence: 99%

Effect of dietary oils from various sources on carbohydrate and fat metabolism in mice

Altberg

Hovav

Chapnik

et al. 2020

Food & Nutrition Research

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Background: Dietary oils differ in their fatty acid composition and the presence of additional microcomponents (antioxidants, etc.). These differences are thought to invoke different biochemical pathways, thus affecting fats and carbohydrates metabolism differently. Olive oil (OO) and soybean oil (SO) are common vegetable oils in the local cuisine. Peanuts oils of local varieties are viewed as potential sources of dietary vegetable oils, especially in the food industry. Objective: We examined the effect of four different dietary vegetable oils on carbohydrate and lipid metabolism in mice. The selected oils were OO, high in oleic acid, extracted from cultivated high oleic acid peanut (C-PO), regular peanut oil (PO), and SO. Design: In this study, 32 male C57BL/6J mice were randomly divided into four groups (n = 8 in each group) and were fed with four different diets enriched with 4% (w/w) dietary vegetable oils (OO, C-PO, PO, or SO). After 10 weeks, the mice were sacrificed. Western blot was used to examine proteins such as phospho-AMP-activated protein kinase (p-AMPK), ace-tyl-CoA carboxylase (ACC), cluster of differentiation 36 (CD36), and Sirtuin 1 (SIRT1), whereas real-time polymerase chain reaction (PCR) was used to examine the expression of sterol regulatory element-binding protein-1c (SREBP-1C), fatty acid synthase (FAS), glucose-6-phosphatase (G6Pase), and CD36 transcripts. Results: In mice-fed SO, lipid accumulation was predominately in adipose tissue, accompanied a tendency decrease in insulin sensitivity. Mice-fed OO had lower plasma triglycerides (TG) and increased hepatic CD36 gene expression. The C-PO group presented lower messenger RNA (mRNA) levels in the liver for all examined genes: SREBP-1c, FAS, G6Pase, and CD36. There were no significant differences in weight gain, plasma cholesterol and high-density lipoprotein (HDL) cholesterol levels, hepatic ACC, SIRT1, AMPK, and CD36 protein levels or in liver function among the diets. Discussion: It seems that as long as fat is consumed in moderation, oil types may play a lesser role in the metabolism of healthy individuals. Conclusion: This finding has the potential to increase flexibility in choosing oil types for consumption.

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“…3). Three of the 4 active compounds (IC 50 <5 μM); curcumin (IC 50 = 2.2 μM), α-mangostin (IC 50 = 1.2 μM), and nobiletin (IC 50 = 0.9 μM), are reported to have SIRT1-activating effects (7,17,28,29,41,43,55). Another compound, HMF showing IC 50 = 1.0 μM, is reported to ameliorate brain and bone injuries (30,31,35,36,45), and recently shown to possess anti-metabolic effects (16).…”

Section: Methodsmentioning

confidence: 99%

T-cell activation-inhibitory assay: a proposed novel method for screening caloric restriction mimetics

et al. 2019

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Caloric restriction (CR) is a major contributor to good health and longevity. CR mimetics (CRMs) are a group of plant-derived compounds capable of inducing the benefits of CR. Since a longevity gene, SIRT1, inhibits T-cell activation and SIRT1 loss results in increased T-cell activation, we hypothesized that compounds capable of activating SIRT1 signaling can inhibit T-cell activation and function as CRMs. Thus we propose, in the present study, the application of a T-cell activation-inhibitory assay to screen candidate CRMs. Well-known CRMs, such as resveratrol, butein, and fisetin, suppressed the anti-CD3/CD28 antibody-induced activation of mouse spleen T-cells. We next randomly assessed 68 plant-derived compounds for screening novel candidate CRMs using this bioassay and found that all four compounds showing IC 50 values <5 μM, such as curcumin, α-mangostin, nobiletin, and heptamethoxyflavone, have beneficial functions for health such as anti-inflammatory effect. These results suggest that the T-cell activation-inhibitory assay can be used to screen candidate CRMs.

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Impact of curcumin on sirtuins: A review

Cited by 51 publications

References 111 publications

SIRT1 Activation by Natural Phytochemicals: An Overview

SIRT1 Activation by Natural Phytochemicals: An Overview

Effect of dietary oils from various sources on carbohydrate and fat metabolism in mice

T-cell activation-inhibitory assay: a proposed novel method for screening caloric restriction mimetics

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