Impact of curcumin on the regulation of microRNAs in colorectal cancer

Simental‐Mendía, Luis E.; Caraglia, Michele; Majeed, Muhammed; Sahebkar, Amirhossein

doi:10.1080/17474124.2017.1268528

Cited by 10 publications

(6 citation statements)

References 26 publications

(29 reference statements)

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“…Curcumin is also reported to be beneficial in arthritis ( Ahmed et al, 2005 ; Chandran and Goel, 2012 ), neurodegenerative diseases ( Ramassamy, 2006 ; Cole et al, 2007 ) and autoimmune conditions ( Bright, 2007 ). Increasing evidences have shown that curcumin exhibits anti-tumor activity ( Aggarwal et al, 2003 ; Kunnumakkara et al, 2008 ; Kasi et al, 2016 ) in several cancers, including CRC ( Tong et al, 2016 ; Guo et al, 2017 ; Simental-Mendia et al, 2017 ; Xu et al, 2017 ), but the detailed mechanism is still unclear.…”

Section: Discussionmentioning

confidence: 99%

“…Curcumin is the major yellow pigment and spice in turmeric and curry, and is a powerful anti-cancer agent ( Zhou et al, 2017 ). Studies indicate that curcumin has anti-tumor effects on several cancers, including CRC ( Tong et al, 2016 ; Guo et al, 2017 ; Simental-Mendia et al, 2017 ; Xu et al, 2017 ), but the detailed mechanisms are still unclear.…”

Section: Introductionmentioning

confidence: 99%

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Curcumin Suppresses the Colon Cancer Proliferation by Inhibiting Wnt/β-Catenin Pathways via miR-130a

et al. 2017

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Curcumin exhibits anti-tumor effects in several cancers, including colorectal carcinoma (CRC), but the detailed mechanisms are still unclear. Here we studied the mechanisms underlying the anti-tumor effect of curcumin in colon cancer cells. SW480 cells were injected into mice to establish the xenograft tumor model, followed by evaluation of survival rate with the treatment of curcumin. The expression levels of β-catenin, Axin and TCF4 were measured in the SW480 cells in the absence or presence of curcumin. Moreover, miRNAs related to the curcumin treatment were also detected in vitro. Curcumin could suppress the growth of colon cancer cells in the mouse model. This anti-tumor activity of curcumin was exerted by inhibiting cell proliferation rather than promoting cell apoptosis. Further study suggested that curcumin inhibited cell proliferation by suppressing the Wnt/β-catenin pathway. MiR-130a was down-regulated by curcumin treatment, and overexpressing miR-130a could abolish the anti-tumor activity of curcumin. Our study confirms that curcumin is able to inhibit colon cancer by suppressing the Wnt/β-catenin pathways via miR-130a. MiR-130a may serve as a new target of curcumin for CRC treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Curcumin Suppresses the Colon Cancer Proliferation by Inhibiting Wnt/β-Catenin Pathways via miR-130a

et al. 2017

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“…Curcumin has demonstrated anti-invasive effects through downregulation of matrix metalloproteinase (MMP-2) and upregulation of tissue inhibitor of metalloproteinase (TIMP-1) in MDA-MB-231 breast cancer cells (54). Interestingly, emerging evidence indicates that the chemopreventive and chemotherapeutic properties of curcumin are closely linked to the modulation of miRNAs involved in tumorigenesis and metastasis signaling pathways, e.g., hedgehog, notch-1, PI3K/Akt/mTOR, Wnt/bcatenin, IGF, VEGF, and TGF-b/smad3 pathways (55,56). Gallardo et al (57) demonstrated that curcumin prevents the migration and invasion of breast cancer cells (MCF-10F and MDA-MB-231) by targeting miR-34a as a regulator of Rho-A and other genes involved in epithelial-mesenchymal transition, such as Axl, Slug, and CD24 (57).…”

Section: Summary Of Evidencementioning

confidence: 99%

In Vivo Efficacy and Toxicity of Curcumin Nanoparticles in Breast Cancer Treatment: A Systematic Review

et al. 2021

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Breast cancer is one of the most prevalent types of malignant tumors in the world, resulting in a high incidence of death. The development of new molecules and technologies aiming to apply more effective and safer therapy strategies has been intensively explored to overcome this situation. The association of nanoparticles with known antitumor compounds (including plant-derived molecules such as curcumin) has been considered an effective approach to enhance tumor growth suppression and reduce adverse effects. Therefore, the objective of this systematic review was to summarize published data regarding evaluations about efficacy and toxicity of curcumin nanoparticles (Cur-NPs) in in vivo models of breast cancer. The search was carried out in the databases: CINAHL, Cochrane, LILACS, Embase, FSTA, MEDLINE, ProQuest, BSV regional portal, PubMed, ScienceDirect, Scopus, and Web of Science. Studies that evaluated tumor growth in in vivo models of breast cancer and showed outcomes related to Cur-NP treatment (without association with other antitumor molecules) were included. Of the 528 initially gathered studies, 26 met the inclusion criteria. These studies showed that a wide variety of NP platforms have been used to deliver curcumin (e.g., micelles, polymeric, lipid-based, metallic). Attachment of poly(ethylene glycol) chains (PEG) and active targeting moieties were also evaluated. Cur-NPs significantly reduced tumor volume/weight, inhibited cancer cell proliferation, and increased tumor apoptosis and necrosis. Decreases in cancer stem cell population and angiogenesis were also reported. All the studies that evaluated toxicity considered Cur-NP treatment to be safe regarding hematological/biochemical markers, damage to major organs, and/or weight loss. These effects were observed in different in vivo models of breast cancer (e.g., estrogen receptor-positive, triple-negative, chemically induced) showing better outcomes when compared to treatments with free curcumin or negative controls. This systematic review supports the proposal that Cur-NP is an effective and safe therapeutic approach in in vivo models of breast cancer, reinforcing the currently available evidence that it should be further analyzed in clinical trials for breast cancer treatments.

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“…The esophagus, which carries food and liquid from the mouth to the stomach, undergoes transient lower esophageal sphincter relaxation (TLESR), which is considered the main mechanism of gastroesophageal reflux disease (GERD) [10]. Under physiological conditions, these TLESRs are induced spontaneously without swallowing and allow for the “physiological” contact of gastric juice containing hydrochloric acid (HCl) with the esophageal wall [10]. Interestingly, this acid reflux occurs at a higher frequency during TLESR in patients with GERD than in healthy subjects [10,11].…”

Section: Curcumin In the Protection Of The Esophagus Against Reflumentioning

confidence: 99%

“…Under physiological conditions, these TLESRs are induced spontaneously without swallowing and allow for the “physiological” contact of gastric juice containing hydrochloric acid (HCl) with the esophageal wall [10]. Interestingly, this acid reflux occurs at a higher frequency during TLESR in patients with GERD than in healthy subjects [10,11]. Furthermore, the anatomical abnormalities in the structure of the lower esophageal sphincter or its dysfunction can result in more frequent or sometimes prolonged exposure of the esophageal mucosa to gastric acid, resulting in esophageal damage due to reflux esophagitis.…”

Section: Curcumin In the Protection Of The Esophagus Against Reflumentioning

confidence: 99%

Curcumin: A Potent Protectant against Esophageal and Gastric Disorders

Kwiecień

Magierowski

Majka

et al. 2019

IJMS

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Turmeric obtained from the rhizomes of Curcuma longa has been used in the prevention and treatment of many diseases since the ancient times. Curcumin is the principal polyphenol isolated from turmeric, which exhibits anti-inflammatory, antioxidant, antiapoptotic, antitumor, and antimetastatic activities. The existing evidence indicates that curcumin can exert a wide range of beneficial pleiotropic properties in the gastrointestinal tract, such as protection against reflux esophagitis, Barrett’s esophagus, and gastric mucosal damage induced by nonsteroidal anti-inflammatory drugs (NSAIDs) and necrotizing agents. The role of curcumin as an adjuvant in the treatment of a Helicobacter pylori infection in experimental animals and humans has recently been proposed. The evidence that this turmeric derivative inhibits the invasion and proliferation of gastric cancer cells is encouraging and warrants further experimental and clinical studies with newer formulations to support the inclusion of curcumin in cancer therapy regimens. This review was designed to analyze the existing data from in vitro and in vivo animal and human studies in order to highlight the mechanisms of therapeutic efficacy of curcumin in the protection and ulcer healing of the upper gastrointestinal tract, with a major focus on addressing the protection of the esophagus and stomach by this emerging compound.

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Impact of curcumin on the regulation of microRNAs in colorectal cancer

Cited by 10 publications

References 26 publications

Curcumin Suppresses the Colon Cancer Proliferation by Inhibiting Wnt/β-Catenin Pathways via miR-130a

Curcumin Suppresses the Colon Cancer Proliferation by Inhibiting Wnt/β-Catenin Pathways via miR-130a

In Vivo Efficacy and Toxicity of Curcumin Nanoparticles in Breast Cancer Treatment: A Systematic Review

Curcumin: A Potent Protectant against Esophageal and Gastric Disorders

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