Impact of cyclic bending on coronary hemodynamics

Wang, Jiaqiu; Fang, Runxin; Wu, Hao; Xiang, Yuqiao; Mendieta, Jessica Benitez; Paritala, Phani Kumari; Fan, Zhenya; Anbananthan, Haveena; Catano, Jorge Alberto Amaya; Raffel, Corey; Li, Zhi Yong

doi:10.1007/s10237-022-01677-z

Cited by 1 publication

(1 citation statement)

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“…Ramaswamy et al [ 36 ] and Zeng et al [ 53 ] performed CFD analyses on a reconstructed LAD and RCA respectively, providing more physiological representative studies, which also revealed an influence of cyclic bending on WSS distributions. More recently, studies based on FSI simulation methods have been presented, incorporating the distensibility of the vessel wall, such as that of Wang et al [ 48 ] who found influence of cyclic bending on time averaged WSS and OSI as a function of heart rate.…”

Section: Introductionmentioning

confidence: 99%

Considering the Influence of Coronary Motion on Artery-Specific Biomechanics Using Fluid–Structure Interaction Simulation

Fogell,

Patel,

Yang

et al. 2023

Ann Biomed Eng

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The endothelium in the coronary arteries is subject to wall shear stress and vessel wall strain, which influences the biology of the arterial wall. This study presents vessel-specific fluid–structure interaction (FSI) models of three coronary arteries, using directly measured experimental geometries and boundary conditions. FSI models are used to provide a more physiologically complete representation of vessel biomechanics, and have been extended to include coronary bending to investigate its effect on shear and strain. FSI both without- and with-bending resulted in significant changes in all computed shear stress metrics compared to CFD (p = 0.0001). Inclusion of bending within the FSI model produced highly significant changes in Time Averaged Wall Shear Stress (TAWSS) + 9.8% LAD, + 8.8% LCx, − 2.0% RCA; Oscillatory Shear Index (OSI) + 208% LAD, 0% LCx, + 2600% RCA; and transverse wall Shear Stress (tSS) + 180% LAD, + 150% LCx and + 200% RCA (all p < 0.0001). Vessel wall strain was homogenous in all directions without-bending but became highly anisotropic under bending. Changes in median cyclic strain magnitude were seen for all three vessels in every direction. Changes shown in the magnitude and distribution of shear stress and wall strain suggest that bending should be considered on a vessel-specific basis in analyses of coronary artery biomechanics.

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Section: Introductionmentioning

confidence: 99%