2023
DOI: 10.1097/fpc.0000000000000494
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Impact of CYP3A5 genotype on de-novo LCP tacrolimus dosing and monitoring in kidney transplantation

Abstract: Objectives LCP tac has a recommended starting dose of 0.14 mg/kg/day in kidney transplant. The goal of this study was to assess the influence of CYP3A5 on perioperative LCP tac dosing and monitoring. MethodsThis was a prospective observational cohort study of adult kidney recipients receiving de-novo LCP tac. CYP3A5 genotype was measured and 90-day pharmacokinetic and clinical were assessed. Patients were classified as CYP3A5 expressors (*1 homozygous or heterozygous) or nonexpressors (LOF *3/*6/*7 allele). Re… Show more

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