Impact of Depression Mood Disorder on the Adverse Drug Reaction Incidence Rate of Anticancer Drugs in Cancer Patients

Zhou, Ting; Duan, Jun-Jie; Zhou, Guangping; Cai, Jingli; Huang, Zhe; Zeng, Yingtong; Xu, Feng

doi:10.1177/147323001003800631

Cited by 6 publications

(5 citation statements)

References 30 publications

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“…Clinical evidences indicated that anorexia nervosa often occurs in individuals with stress, anxiety-like, or depressionlike behavior (Lian et al, 2017;Lloyd et al, 2019), suggesting the possible association between mood disorder and anorexia. Similar to this finding, our previous work also noted that cancer chemotherapy patients with severe depression seemed more likely to have frequent and severe adverse drug reactions including anorexia, nausea, and fatigue (Zhou et al, 2010). Nausea and vomiting, one of the most terrible adverse reactions experienced by cancer patients, is associated with multiple risk factors including gender, age, anticancer drug dose, history of morning sickness, and alcohol intake.…”

Section: Discussionsupporting

confidence: 80%

“…In our previous work, we found that the frequency and extent of subjectively experienced adverse drug reactions (anorexia, nausea, and fatigue) in cancer chemotherapy patients seemed to be well in line with the severity of their depression (Zhou et al, 2010). Chronic stress pretreatment might aggravate the vomiting process; however, the underlying mechanism is still not clear.…”

Section: Introductionmentioning

confidence: 95%

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Cisplatin-Induced Anorexia and Pica Behavior in Rats Enhanced by Chronic Stress Pretreatment

et al. 2022

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Background: Chemotherapy-induced nausea and vomiting severely impairs the treatment and prognosis of cancer patients. Depressive mood disorder might aggravate nausea and vomiting in cancer patients; however, the role of neurotransmitters and receptors involved in the mediation of emesis and nausea is still not well elaborated.Methods: The study was carried out based on the chronic unpredictable mild stress–induced depression-like phenotype rat model and cisplatin-induced pica rat model establishment. Forty male Sprague–Dawley rats were randomized into the non-treated control group and the chronic stress group, which were exposed to 8 weeks of stress. Each group was then sub-divided into vehicle subgroups (n = 10) and cisplatin subgroups (n = 10) which were given cisplatin to induce pica behavior. Kaolin and food intake were recorded after administration. The medulla oblongata and ileum tissues were obtained. Neurotransmitters involved in the mediation of emesis and nausea (5-HT, DA, SP, and AEA) were detected using an ELISA kit. Vomit-related receptors (5-HT3R, DA2R, NK1R, and CB1R) in tissues were assayed for mRNA and protein expression by RT-qPCR and Western blotting.Results: Behavioral test and sucrose preference validated that depression-like phenotype rat models were established successfully. The kaolin consumption test confirmed that chronic stress pretreatment aggravated anorexia and pica behavior. Vomiting-related molecules’ data showed that chronic stress exposure increased 5-HT and SP levels in the medulla oblongata. Vomiting-related receptor expression data showed that chronic stress pretreatment upregulated 5-HT3R, DA2R, and NK1R expressions and downregulated the CB1R expression in the medulla oblongata. However, chronic stress pretreatment downregulated 5-HT3R, DA2R, and NK1R expressions and upregulated the CB1R expression in the ileum.Conclusion: Chronic stress pretreatment aggravates anorexia and vomiting progress, which might be via altering neurotransmitters and receptors involved in the mediation of emesis and the nausea level and expression in the central nervous system.

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 95%

Cisplatin-Induced Anorexia and Pica Behavior in Rats Enhanced by Chronic Stress Pretreatment

et al. 2022

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“…Depression has been found in multiple populations to be associated with increased ADEs. [16–18] It is currently unclear why depression was higher in ED visits for ADE in non-dialysis patients.…”

Section: Discussionmentioning

confidence: 99%

National Trends in Emergency Room Visits of Dialysis Patients for Adverse Drug Reactions

et al. 2018

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Background: Various medications are cleared by the kidneys, therefore patients with impaired renal function, especially dialysis patients are at risk for adverse drug events (ADEs). There are limited studies on ADEs in maintenance dialysis patients. Methods: We utilized a nationally representative database, the Nationwide Emergency Department Sample, from 2008 to 2013, to compare emergency department (ED) visits for dialysis and propensity matched non-dialysis patients. Log binomial regression was used to calculate relative risk of hospital admission and logistic regression to calculate ORs for in-hospital mortality while adjusting for patient and hospital characteristics. Results: While ED visits for ADEs decreased in both groups, they were over 10-fold higher in dialysis patients than non-dialysis patients (65.8–88.5 per 1,000 patients vs. 4.6–5.4 per 1,000 patients respectively, p < 0.001). The top medication category associated with ED visits for ADEs in dialysis patients is agents primarily affecting blood constituents, which has increased. After propensity matching, patient admission was higher in dialysis patients than non-dialysis patients, (88 vs. 76%, p < 0.001). Dialysis was associated with a 3% increase in risk of admission and 3 times the odds of in-hospital mortality (adjusted OR 3, 95% CI 2.7–2.3.3). Conclusions: ED visits for ADEs are substantially higher in dialysis patients than non-dialysis patients. In dialysis patients, ADEs associated with agents primarily affecting blood constituents are on the rise. ED visits for ADEs in dialysis patients have higher inpatient admissions and in-hospital mortality. Further studies are needed to identify and implement measures aimed at reducing ADEs in dialysis patients.

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“…En un estudio realizado por Zhou et al (47) se encontró que la frecuencia y la extensión de las reacciones adversas a los medicamentos no están relacionadas con la depresión, pero sí lo está la experiencia subjetiva que el paciente tiene ante estas reacciones (anorexia, nausea y fatiga).…”

Section: Factores Psicológicos Que Disminuyen La Probabilidad De Adherenciaunclassified

Adherencia a la quimioterapia y radioterapia en pacientes oncológicos: una revisión de la literatura

Palacios‐Espinosa

Vargas-Sterling

2012

Psicooncología

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Objective: To review in databases the relevant literature of adherence to chemotherapy and radiotherapy for cancer; which bring high biological, psychological, social and cultural costs and have been related to lower adherence rates. Method: A search in different databases was performed to identify relevant articles related to the key words. Results: A significant percentage of patients do not adhere to cancer treatments and the consequences of not doing it can unleash in a major risk of death or disease progression, then it is essential to approach this topic and take into account different variables of biological, psychological and social impact on the behavior of adherence or not adherence to the treatments; including the side effects, motivation, decision-making ability, emotional condition, autonomy and life philosophy of each patient. This research contributes to the health staff have more elements to approach this problem and so his interventions are more effective being able to increase the patient´s adherence. Conclusions: Adherence is a multifactorial and multi-determined construct, which has been extensively studied in non cancer treatments (e.g. AIDS) and there is few investigation that supports the efficacy of the psychological interventions to approach not adherence and to promote the adherence to cancer treatments.

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Impact of Depression Mood Disorder on the Adverse Drug Reaction Incidence Rate of Anticancer Drugs in Cancer Patients

Cited by 6 publications

References 30 publications

Cisplatin-Induced Anorexia and Pica Behavior in Rats Enhanced by Chronic Stress Pretreatment

Cisplatin-Induced Anorexia and Pica Behavior in Rats Enhanced by Chronic Stress Pretreatment

National Trends in Emergency Room Visits of Dialysis Patients for Adverse Drug Reactions

Adherencia a la quimioterapia y radioterapia en pacientes oncológicos: una revisión de la literatura

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