Impact of diabetes mellitus on myocardial lipid deposition: An autopsy study

Nakanishi, Takaya; Kato, Seiya

doi:10.1016/j.prp.2014.04.008

Cited by 20 publications

(18 citation statements)

References 43 publications

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“…Human genetic ATGL deficiency (10,11) has turned out to be ultra-rare (12) and only 47 patients identified globally, since we launched the Japan TGCV study group in 2009. However, our postmortem analyses (13,14) for subjects who died of cardiovascular diseases demonstrated that substantial numbers of autopsied individuals showed TGCV phenotype, most of who had suffered from diabetes mellitus. The amount of triglycerides in the coronary artery of patients who died of cardiovascular complications was several times higher in diabetic patients than in non-diabetic patients.…”

Section: T Riglyceride Deposit Cardiomyovasculopathy (Tgcv) Is Amentioning

confidence: 85%

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Imaging Modalities for Triglyceride Deposit Cardiomyovasculopathy

Higashi

Ikeda

Miyauchi

et al. 2017

Annals of Nuclear Cardiology

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Triglyceride deposit cardiomyovasculopathy (TGCV) is a novel clinical entity we found in patients withThese results suggest that TGCV might be difficult to diagnose in daily clinics, however be more prevalent than expected, and a possible important cause of cardiac death. This review article focuses on imaging modalities to evaluate cardiomyovascular TG accumulation of this novel disease. Data and images are shown from pathological analyses, imaging mass spectrometry, myocardial scintigraphy with a radioactive analogue for LCFA, iodine-123-β-methyl iodophenyl-pentadecanoic acid, MR spectroscopy, and CT-based TG imagings in primary TGCV patients with genetic ATGL deficiency, which is ultra-rare, but the monogenic model.

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Section: T Riglyceride Deposit Cardiomyovasculopathy (Tgcv) Is Amentioning

confidence: 85%

“…4) (13,14). As with primary TGCV, patients with idiopathic TGCV also exhibit triglyceride accumulation in cardiac muscle and …”

Section: Idiopathic Tgcvmentioning

confidence: 99%

Imaging Modalities for Triglyceride Deposit Cardiomyovasculopathy

Higashi

Ikeda

Miyauchi

et al. 2017

Annals of Nuclear Cardiology

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“…32–35 Accumulation of intramyocardial lipids occurs in diabetes and is associated with increased myocardial infarction events and heart failure compared to individuals with less cardiac lipid droplet formation. 36 Increased incidence and prevalence of heart failure in diabetic and obese patients with the metabolic syndrome is independent from the development of accelerated atherosclerosis. 37–39 A link seems to exist between obesity and diabetes and left ventricular hypertrophy in correlation with TAG accumulation and cardiac steatosis.…”

Section: Evidence Of Lipotoxicity In the Human Heartmentioning

confidence: 99%

Lipid Use and Misuse by the Heart

Schulze

Drosatos

Goldberg

2016

Circulation Research

258

219

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The heart utilizes large amounts of fatty acids as energy providing substrates. The physiologic balance of lipid uptake and oxidation prevents accumulation of excess lipids. Several processes that affect cardiac function including ischemia, obesity, diabetes, sepsis, and most forms of heart failure lead to altered fatty acid oxidation and often also to the accumulation of lipids. There is now mounting evidence associating certain species of these lipids with cardiac lipotoxicity and subsequent myocardial dysfunction. Experimental and clinical data are discussed and paths to reduction of toxic lipids as a means to improve cardiac function are suggested.

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“…Adult diabetic cardiomyopathy is characterized by diastolic and then systolic dysfunction, cardiac hypertrophy, and heart failure that is relatively independent of other vascular risk factors (9,25). Lipid droplet accumulation is found on biopsy, which is suggestive of a lipid-mediated etiology (9,26,46). It is certainly plausible that excess circulating maternal fuels and fetal hyperinsulinemia trigger a similar process in the developing heart.…”

mentioning

confidence: 99%

Maternal high-fat diet impairs cardiac function in offspring of diabetic pregnancy through metabolic stress and mitochondrial dysfunction

Mdaki

Larsen

Wachal

et al. 2016

American Journal of Physiology-Heart and Circulatory Physiology

161

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Offspring of diabetic pregnancies are at risk of cardiovascular disease at birth and throughout life, purportedly through fuel-mediated influences on the developing heart. Preventative measures focus on glycemic control, but the contribution of additional offenders, including lipids, is not understood. Cellular bioenergetics can be influenced by both diabetes and hyperlipidemia and play a pivotal role in the pathophysiology of adult cardiovascular disease. This study investigated whether a maternal high-fat diet, independently or additively with diabetes, could impair fuel metabolism, mitochondrial function, and cardiac physiology in the developing offspring's heart. Sprague-Dawley rats fed a control or high-fat diet were administered placebo or streptozotocin to induce diabetes during pregnancy and then delivered offspring from four groups: control, diabetes exposed, diet exposed, and combination exposed. Cardiac function, cellular bioenergetics (mitochondrial stress test, glycolytic stress test, and palmitate oxidation assay), lipid peroxidation, mitochondrial histology, and copy number were determined. Diabetes-exposed offspring had impaired glycolytic and respiratory capacity and a reduced proton leak. High-fat diet-exposed offspring had increased mitochondrial copy number, increased lipid peroxidation, and evidence of mitochondrial dysfunction. Combination-exposed pups were most severely affected and demonstrated cardiac lipid droplet accumulation and diastolic/systolic cardiac dysfunction that mimics that of adult diabetic cardiomyopathy. This study is the first to demonstrate that a maternal high-fat diet impairs cardiac function in offspring of diabetic pregnancies through metabolic stress and serves as a critical step in understanding the role of cellular bioenergetics in developmentally programmed cardiac disease.

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Impact of diabetes mellitus on myocardial lipid deposition: An autopsy study

Cited by 20 publications

References 43 publications

Imaging Modalities for Triglyceride Deposit Cardiomyovasculopathy

Imaging Modalities for Triglyceride Deposit Cardiomyovasculopathy

Lipid Use and Misuse by the Heart

Maternal high-fat diet impairs cardiac function in offspring of diabetic pregnancy through metabolic stress and mitochondrial dysfunction

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