Impact of diabetes mellitus on rifampicin's plasma concentration and bioavailability in patients with tuberculosis: A systematic review and meta-analysis study

El-Sheikh, Sawsan M.A.; Metwally, Amera Sh.; Galal, Azza A.A.

doi:10.1016/j.therap.2022.05.005

Cited by 2 publications

(3 citation statements)

References 43 publications

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“…This is consistent with previous reports [ 41 , 42 , 43 ] and could be due to the early appearance of these mutations in the genome of resistant strains [ 44 ], as well as the low fitness of these variants, which makes them more transmissible in bacteria [ 45 ]. We also observed a higher frequency of these SNPs in isolates from individuals with the T2DM-TB binomial, possibly because of the decreased plasma concentration of anti-TB drugs [ 12 , 13 , 14 ] and/or interference by drugs used for glycemic control [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…It also acts to promote the elongation of active infection and proliferation of TB bacilli [ 10 , 11 ]. This unfavorable evolution has been partially explained by the decreased plasma concentrations of anti-TB drugs [ 12 , 13 , 14 ], interference by drugs used for glycemic control [ 15 ], and immunological alterations [ 16 , 17 , 18 , 19 , 20 , 21 ]. Regrettably, growth in the incidence of type 2 diabetes mellitus in the coming years is mainly expected to affect low-income countries, which also have the highest levels of tuberculosis and drug-resistant tuberculosis, so the frequency of this binomial is expected to increase significantly in the coming years, hindering the possibility for controlling TB in the next decade.…”

Section: Introductionmentioning

confidence: 99%

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Mutational Dynamics Related to Antibiotic Resistance in M. tuberculosis Isolates from Serial Samples of Patients with Tuberculosis and Type 2 Diabetes Mellitus

Bermúdez-Hernández,

Pérez-Martínez,

Ortiz-León

et al. 2024

Microorganisms

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Genetic variation in tuberculosis is influenced by the host environment, patients with comorbidity, and tuberculosis–type 2 diabetes mellitus (TB-T2DM) and implies a higher risk of treatment failure and development of drug resistance. Considering the above, this study aimed to evaluate the influence of T2DM on the dynamic of polymorphisms related to antibiotic resistance in TB. Fifty individuals with TB-T2DM and TB were initially characterized, and serial isolates of 29 of these individuals were recovered on day 0 (diagnosis), 30, and 60. Genomes were sequenced, variants related to phylogeny and drug resistance analyzed, and mutation rates calculated and compared between groups. Lineage X was predominant. At day 0 (collection), almost all isolates from the TB group were sensitive, apart from four isolates from the TB-T2DM group showing the mutation katG S315T, from which one isolate had the mutations rpoB S450L, gyrA A90G, and gyrA D94G. This pattern was observed in a second isolate at day 30. The results provide a first overview of the dynamics of mutations in resistance genes from individuals with TB-T2DM, describing an early development of resistance to isoniazid and a rapid evolution of resistance to other drugs. Although preliminary, these results help to explain the increased risk of drug resistance in individuals with TB and T2DM.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mutational Dynamics Related to Antibiotic Resistance in M. tuberculosis Isolates from Serial Samples of Patients with Tuberculosis and Type 2 Diabetes Mellitus

Bermúdez-Hernández,

Pérez-Martínez,

Ortiz-León

et al. 2024

Microorganisms

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“…The review included studies published up until September 2020 and identified seven studies from which pooled estimates were calculated. The same authors updated their systematic review including studies with C max at 2hr, 51 and identified 17 studies reporting RIF plasma concentrations.…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review on the Effect of Diabetes Mellitus on the Pharmacokinetics of Tuberculosis Drugs

Cevik,

Sturdy,

Maraolo

et al. 2023

Preprint

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While pharmacokinetics (PK) of many drugs is known to be altered in individuals with diabetes mellitus (DM), the effects of DM on the PK of anti-tuberculosis (TB) drugs remains poorly understood.We performed a systematic review through searches of major databases from 1946 to 6 July 2023. The literature search identified 4173 potentially relevant articles. After reviewing the eligibility criteria, 21 articles were included that assessed the PK of anti-TB drugs among patients with DM.Most articles focused on first line TB drugs; we identified 16 studies assessing rifampicin PK, 9 studies on isoniazid, 8 on pyrazinamide and 3 assessing ethambutol. Only 2 studies reported on second line anti-TB treatment. While some studies showed lower plasma concentrations of TB medications among DM patients, this finding was not consistent. In addition, we observed high variability in findings and significant heterogeneity among studies in terms of study design and differences in demographics.This review provides detailed overview of the limited evidence available regarding the PK of anti-TB medications in patients with DM. However, due to significant heterogeneity between studies, no conclusions could be made. Adequately designed PK studies using standardise methodologies are urgently needed to make recommendations regarding drug dosing in patients affected both by TB and DM.

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Impact of diabetes mellitus on rifampicin's plasma concentration and bioavailability in patients with tuberculosis: A systematic review and meta-analysis study

Cited by 2 publications

References 43 publications

Mutational Dynamics Related to Antibiotic Resistance in M. tuberculosis Isolates from Serial Samples of Patients with Tuberculosis and Type 2 Diabetes Mellitus

Mutational Dynamics Related to Antibiotic Resistance in M. tuberculosis Isolates from Serial Samples of Patients with Tuberculosis and Type 2 Diabetes Mellitus

A Systematic Review on the Effect of Diabetes Mellitus on the Pharmacokinetics of Tuberculosis Drugs

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