Impact of diabetes on the management and outcomes in atrial fibrillation: an analysis from the ESC-EHRA EORP-AF Long-Term General Registry

Adverse Events and Clinical Correlates in Asian Patients with Atrial Fibrillation and Diabetes Mellitus: A Report from Asia Pacific Heart Rhythm Society Atrial Fibrillation Registry

“…The DM prevalence of about 25% we found in our Asian population was similar to the 23% showed in the EORP-AF registry conducted in European AF patients [15] and to the pooled prevalence of 26% reported in a recent metanalysis on more than 500,000 AF patients from different geographical areas [16], suggesting that ethnicity plays a marginal…”

“…The DM prevalence of about 25% we found in our Asian population was similar to the 23% showed in the EORP-AF registry conducted in European AF patients [15] and to the pooled prevalence of 26% reported in a recent metanalysis on more than 500,000 AF patients from different geographical areas [16], suggesting that ethnicity plays a marginal role on the differences for DM prevalence in AF patients. Moreover, also the clinical phenotype of AF patients with DM, characterized by advanced age, worse quality of life, and high prevalence of obesity and other cardiovascular risk factors, was consistent to those described in previous studies from European countries, underlying the clinical complexity of these patients, and explaining the higher use of OAC we found [17][18][19].…”

“…However, our data seem to further suggest that Asian patients with DM have a greater risk of clinical complications and death compared to Western patients. Indeed, if the 48% increased risk of all-cause death we reported is similar to the pooled 43% reported in the above mentioned metanalysis, it is certainly higher than the 28% higher risk showed by AF patients with DM from the EORP-AF registry [15,16]. The same could be said for the 2-fold increased risk of cardiovascular death we have reported in our patients with DM, a value significantly higher than the 40% increased risk reported in studies performed on European AF populations [15,36].…”

Impact of preexisting diabetes mellitus on cardiovascular and all-cause mortality in patients with atrial fibrillation: A meta-analysis

“…Ten studies ( 9 , 15 , 16 , 19 , 20 , 24 – 27 , 29 ) provided data on the association of diabetes mellitus with cardiovascular mortality. A fixed-effects model meta-analysis suggested that diabetes mellitus was associated with an increased risk of cardiovascular mortality (RR 1.46; 95% CI 1.34–1.58; I 2 = 0%, p = 0.594; Figure 4 ) compared with those without diabetes.…”

Atrial fibrillation: comorbidities, lifestyle, and patient factors

“…Diabetes mellitus is prevalent in 20–25% of people with AF 143 and optimising the management of diabetes is also a key element in the ‘C’ part of the ABC pathway. 135 Treatment should focus on glycaemic control and management of other risk factors associated with diabetes (obesity, physical inactivity, poor diet, and alcohol consumption).…”