Impact of dietary regimen on the duration of cow's milk allergy: a random allocation study

Abstract

Patients not exposed to cow's milk protein residue achieve cow's milk tolerance earlier than patients who follow an extensively hydrolysed cow's milk diet. This may be due to residual antigenicity in hydrolysed milks. As the effect of dietary intervention is stronger in patients not sensitized to soy, we infer that when atopic disease has progressed to multiple sensitizations, the elimination of allergenic exposure may not be sufficient to reduce the duration of CMA.

Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA): A summary report

“…83 These developments might lead to clinical breakthroughs in the near future, hopefully leading to tests assisting clinicians in characterizing phenotypical expression of CMA and thus defining patients' prognostic profiles. 170 In conclusion, DRACMA should contribute to research by focusing a worldwide awareness to deal with the unmet needs that current CMA research has identified. Toward these goals, the WAO provides an instrument and a forum to generate solutions to clinical aspects of the problem and to coordinate energies from the multidisciplinary approaches needed to tackle the problem of CMA.…”

Profile of a milk-allergic patient who tolerated partially hydrolyzed whey formula

“…1 In formula-fed infants with CM allergy, extensively hydrolyzed, amino acid-based, or soy formulas are typically recommended. 2 Here we report a case where assessment for allergy to specific CM proteins allowed for formula choice beyond the typical recommendations.…”

“…5 Other studies have addressed the potential effects of formula selection on the natural history of CM allergy, but pHWFs were not specifically examined. 2, 6, 7 pHWF may carry unique immunoregulatory characteristics. 8,9 …”

Extensively heated milk and egg as oral immunotherapy

“…This issue is being addressed in an ongoing baked milk trial (unpublished data). Although limited, there are data that patients not exposed to cow's milk protein residue achieve tolerance to cow's milk earlier than patients who follow an extensively hydrolyzed cow's milk diet [45].…”