2021
DOI: 10.33594/000000375
|View full text |Cite
|
Sign up to set email alerts
|

Impact of Diverse Ion Channels on Regulatory T Cell Functions

Abstract: The population of regulatory T cells (Tregs) is critical for immunological self-tolerance and homeostasis. Proper ion regulation contributes to Treg lineage identity, regulation, and effector function. Identified ion channels include Ca2+ release-activated Ca2+, transient receptor potential, P2X, volume-regulated anion and K+ channels Kv1.3 and KCa3.1. Ion channel modulation represents a promising therapeutic approach for the treatment of autoimmune diseases such as rheumatoid arthritis and multiple sclerosis.… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
11
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
5

Relationship

0
5

Authors

Journals

citations
Cited by 6 publications
(11 citation statements)
references
References 89 publications
0
11
0
Order By: Relevance
“…As discussed in Section 2.1.2 , T reg cells play a significant role in RA pathogenesis, and proper ion regulation is required for the regulation and effector function of a cell ( Varga et al, 2009 ; Kotschenreuther et al, 2022 ). T regs are critical contributors to immune tolerance, and defects in their function are associated with autoimmune diseases such as RA ( Vinnenberg et al, 2021 ). The potassium channels, such as voltage-gated K + channel Kv1.3 and calcium-activated K + channel KCa3.1, predominantly control membrane potential in T reg cells ( Vinnenberg et al, 2021 ).…”
Section: Potassium Channels’ Impact On Immune Function and Ramentioning
confidence: 99%
See 4 more Smart Citations
“…As discussed in Section 2.1.2 , T reg cells play a significant role in RA pathogenesis, and proper ion regulation is required for the regulation and effector function of a cell ( Varga et al, 2009 ; Kotschenreuther et al, 2022 ). T regs are critical contributors to immune tolerance, and defects in their function are associated with autoimmune diseases such as RA ( Vinnenberg et al, 2021 ). The potassium channels, such as voltage-gated K + channel Kv1.3 and calcium-activated K + channel KCa3.1, predominantly control membrane potential in T reg cells ( Vinnenberg et al, 2021 ).…”
Section: Potassium Channels’ Impact On Immune Function and Ramentioning
confidence: 99%
“…T regs are critical contributors to immune tolerance, and defects in their function are associated with autoimmune diseases such as RA ( Vinnenberg et al, 2021 ). The potassium channels, such as voltage-gated K + channel Kv1.3 and calcium-activated K + channel KCa3.1, predominantly control membrane potential in T reg cells ( Vinnenberg et al, 2021 ). Both these channels are involved in the antigenic activation and proliferation of T cells, and each channel expresses differently in each T-cell subtype ( Vinnenberg et al, 2021 ).…”
Section: Potassium Channels’ Impact On Immune Function and Ramentioning
confidence: 99%
See 3 more Smart Citations