2017
DOI: 10.1016/j.psyneuen.2017.07.239
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Impact of early life adversity and tryptophan depletion on functional connectivity in menopausal women: A double-blind, placebo-controlled crossover study

Abstract: During the menopause transition, women are at increased risk of subjective symptoms of executive dysfunction. Evidence from animal and human participant studies suggests adverse childhood experiences (ACE) may be a risk factor for executive complaints during this hormonal transition. Preclinical literature indicates early life adversity effects on serotonin function may play a role in this increased susceptibility. However, the mechanisms underlying this increase in vulnerability in human participants remain r… Show more

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Cited by 14 publications
(6 citation statements)
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“…Notably, menstrual cycle phase was not considered in the above studies. Given the prominent effects of gonadal steroids on brain neurochemistry, structure and function [60•, 61, 62, 63•, 64, 65] across various stages of development and preclinical models indicating estrous cycle effects on stress neurocircuitry, we would argue for controlling for hormonal and reproductive status in all stress- and PTSD-focused research.…”
Section: Sex Differences In the Physiologic Response To Traumamentioning
confidence: 99%
“…Notably, menstrual cycle phase was not considered in the above studies. Given the prominent effects of gonadal steroids on brain neurochemistry, structure and function [60•, 61, 62, 63•, 64, 65] across various stages of development and preclinical models indicating estrous cycle effects on stress neurocircuitry, we would argue for controlling for hormonal and reproductive status in all stress- and PTSD-focused research.…”
Section: Sex Differences In the Physiologic Response To Traumamentioning
confidence: 99%
“…Whether these women also experienced a greater number of ACEs is not known, but nevertheless, these findings indicate a role for dysregulated stress physiology in LUTS. Serotonergic alterations are associated with early life adversity 13,14 as well as depression 8 and may play a role in LUTS given that serotonin receptors in the CNS are involved in the control of micturition 9 . Exposure to early life adversity alters dopaminergic circuits, 15 in part by increasing the number of D 2 receptors 16 .…”
Section: Discussionmentioning
confidence: 99%
“…In particular, empirical evidence suggests that early life adversity (eg, childhood abuse and neglect) exposes children to such significant stress that it can alter the hypothalamic-pituitary-adrenal axis and the serotonergic and dopaminergic systems. [12][13][14][15][16] Although the link between childhood adversity and negative affect symptoms is well established, 17 in the next section, we review the evidence for a link between childhood adversity and LUTS and then consider-at the macrolevel-how childhood adversity, negative affect symptoms, and LUTS might be related.…”
Section: Relationship Between Affective Disorders and Lutsmentioning
confidence: 99%
“…The impacts of some experiences or exposures may be measurable immediately, while others may not be manifest until later in the lifespan (Lupien et al, 2009;Bale & Epperson, 2015). For example, exposure to childhood adversity is associated with changes in functional network connectivity and rates of depression at menopause (Epperson et al, 2017;Shanmugan et al, 2017). Moreover, in both rodents and humans, exposure to stress during perinatal, early childhood or adolescent periods impacts developing males and females differently (Sandman et al, 2013;Bale & Epperson, 2015;Oyola & Handa, 2017;Kim et al, 2017;Chan et al, 2018;Goodwill et al, 2018).…”
Section: Embracing Complexitymentioning
confidence: 99%