Impact of EGFR and p53 expressions on survival and quality of life in locally advanced oral squamous cell carcinoma patients treated with chemoradiation

Gupta, Seema; Khan, Huma; Kushwaha, Vikas; Husain, Nuzhat; Negi, M.P.S.; Ghatak, Ashim; Bhatt, M L B

doi:10.1080/15384047.2015.1070985

Cited by 14 publications

(17 citation statements)

References 40 publications

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“…The Indian population can be considered geographically, genetically and habitually close to ours. EGFR positivity was reported in 27.5% and 72.5% of OSCC cases as low and high expression respectively, by Gupta et al which corroborates our findings [33]. Another study concluded a median overexpression of 50% [46].…”

Section: Discussionsupporting

confidence: 82%

“…al also showed that EGFR overexpression was significantly related to recurrence and added that it also meant an early time to recurrence [4]. Moreover, an improved disease-free interval has been observed with low levels of EGFR accompanied by chemoradiation [33]. Another study using tissue microarray technology also concluded that EGFR overexpression (cytoplasmic and membranous both) had a negative prognostic influence as overall and disease-free survival both were lowered [49].…”

Section: Discussionmentioning

confidence: 91%

“…According to Gupta et al, EGFR overexpression lead to lower overall survival, overall response and quality of life in patients with locally advanced OSCC who had been treated with chemoradiation [33]. Furthermore, a meta-analysis of thirty-seven studies was conducted by Keren et al to analyse the prognostic value of EGFR in HNSCC and it revealed that EGFR overexpression to lead to lower survival and diseasefree survival for oropharyngeal carcinoma [34].…”

Section: Ivyspring International Publishermentioning

confidence: 99%

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Overexpression of EGFR in Oral Premalignant Lesions and OSCC and Its Impact on Survival and Recurrence

Mirza¹,

Ali²,

Awan³

et al. 2018

Oncomedicine

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Introduction: Oral squamous cell carcinoma (OSCC) the sixth leading cancer worldwide ranks as the most common cancer in males, and the third most common in females in Pakistan. It is influenced by risk factors which are widely consumed in our population. The epidermal growth factor receptor (EGFR) is a tyrosine kinase receptor that is imperative for cell signalling, growth and differentiation. It is mutated and overexpressed in a variety of cancers, while in OSCC it has been linked to poor patient survival; premalignant to malignant transformation and recurrence. This study investigates the use of EGFR as a prognostic factor for OSCC. Materials and Methods: Premalignant (n=29) and OSCC (n=100) formalin-fixed paraffin-embedded tissues were retrieved from the surgical archives of Aga Khan University Hospital (AKUH). Immunohistochemistry for EGFR overexpression was performed using monoclonal antibody on both groups. EGFR expression was correlated with habits of risk factor consumption, clinicopathologic features and 5-year survival and recurrence. Results: 15/29 premalignant and 67/100 OSCC patients had overexpressed EGFR. The upper/lower lip had the highest EGFR positivity among all premalignant sites of lesion (p=0.041). In OSCC patients, those who had EGFR overexpression had worse 5-year survival (univariate: p=0.048, multivariate: p=0.056) and higher chances of recurrence (univariate: p=0.01, multivariate: p=0.004) as compared to EGFR negative patients. Conclusion: EGFR is a viable candidate for an OSCC prognostic marker since its overexpression leads to poor survival and markedly increases the chances of recurrence.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 91%

Section: Ivyspring International Publishermentioning

confidence: 99%

See 1 more Smart Citation

Overexpression of EGFR in Oral Premalignant Lesions and OSCC and Its Impact on Survival and Recurrence

Mirza¹,

Ali²,

Awan³

et al. 2018

Oncomedicine

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“…Squamous cell carcinoma is by far the most common cancer type of the oral cavity, representing more than 90% of all oral cancer [22]. The overall survival rates have not improved for more than decades even in major treatment centers inspite of all possible definitive treatment approaches; dreadful and alarming event of locoregional relapse is customary and elucidates for major cause of morbidity and mortality in these patients.…”

Section: Discussionmentioning

confidence: 99%

“…Although many molecular markers and tumor markers have been studied and have revolutionized the pathogenesis of head and neck squamous cell carcinoma (HNSCC) still they are not yet ready to be used in routine clinical, investigative and therapeutic procedures in patients with these tumors. Preponderantly tumor stage, patient’s age and performance status still remains the basis for therapeutic decisions [22, 23, 27, 28]. These all have attributed to the urge of advancement and innovations in research approaches of molecular biology, genomics and proteomics with a tremendous hope at the end of tunnel [28].…”

Section: Discussionmentioning

confidence: 99%

Understanding molecular markers in recurrent oral squamous cell carcinoma treated with chemoradiation

Gupta

Kushwaha

Verma

et al. 2016

Heliyon

Self Cite

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IntroductionOral cancer accounts for approximately 2.1% of all cancers worldwide. In India, oral squamous cell carcinoma (OSCC) is the most common cancer with half a million new cases diagnosed every year. More than 50% of patients eventually develop local recurrence or metastasis usually within the first 2-years following completion of treatment. It is beneficial to analyze the prognostic significance of Cyclin D1, p53 and EGFR which are critical mediators in the pathogenesis of OSCC. The objective of this study was to assess the association of expression of these markers with recurrence and pattern of recurrence in OSCC patients undergoing chemoradiation.Materials and MethodsA Total 290 OSCC cases of locally advanced stage (III, IV) oral cancer with World Health Organization (W.H.O.) performance status of grade 0/1 in the year 2009–2012 were enrolled in the study. Treatment response was assessed according to W.H.O. criteria. Cyclin D1, EGFR and p53 expression in tumor tissue was estimated by immunohistochemical (IHC) method and quantified as percentage positive nuclei.ResultsDuring the 2-years follow up, 56 (19.3%) patients recurred, out of which, 47 (83.9%) were locoregional and 9 (16.1%) distant sites. On correlating, χ2 test showed significant (P < 0.05 or P < 0.01 or P < 0.001) association of marker expressions (Cyclin D1, EGFR and p53) with recurrence. The strong positive expressions of all three markers showed significant association with early time of recurrence. The multivariate logistic regression analysis showed significant (P < 0.05 or P < 0.01 or P < 0.001) association of recurrence with primary site, differentiation, Cyclin D1 and p53 expressions indicating these as an independent predictors of recurrence in OSCC. The Cyclin D1, EGFR and p53 expressions also showed significant (P < 0.001) poor survivals (OS, DFS and RFS) in patients with positive/strong positive expressions than negative expression suggesting their prognosis in OSCC.ConclusionOur results signifies that tumors over expressing Cyclin D1, EGFR and p53 are resistant to chemoradiation and are associated with increased risk of locoregional recurrence and metastasis in OSCC patients undergoing chemoradiation.

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Epidermal growth factor receptor detection in serum and saliva as a diagnostic and prognostic tool in oral cancer

et al. 2017

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Impact of EGFR and p53 expressions on survival and quality of life in locally advanced oral squamous cell carcinoma patients treated with chemoradiation

Cited by 14 publications

References 40 publications

Overexpression of EGFR in Oral Premalignant Lesions and OSCC and Its Impact on Survival and Recurrence

Overexpression of EGFR in Oral Premalignant Lesions and OSCC and Its Impact on Survival and Recurrence

Understanding molecular markers in recurrent oral squamous cell carcinoma treated with chemoradiation

Epidermal growth factor receptor detection in serum and saliva as a diagnostic and prognostic tool in oral cancer

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