Impact of Exposure to Ambient Fine Particulate Matter Pollution on Adults with Knee Osteoarthritis

Abstract

The impact of exposure to fine particulate matter (PM2.5) on the incidence of knee osteoarthritis is unclear, especially in Beijing which is a highly polluted city. We conducted a time-series study to examine the correlation between PM2.5 exposure and outpatient visits for knee osteoarthritis in Beijing. Changes (in percentage) in the number of outpatient visits corresponding to every 10-μg/m3 increase in the PM2.5 concentration were determined using a generalized additive quasi-Poisson model. There were records of 9,797,446 outpatient visits for knee osteoarthritis in the study period from 1 January 2010 to 31 December 2017. The daily concentration of PM2.5 was 86.8 (74.3) μg/m3 over this period. A 10-μg/m3 increase in PM2.5 concentrations on lag days 0–3 was associated with a 1.41% (95% confidence interval: 1.40–1.41%) increase in outpatient visits for knee osteoarthritis. Females and patients aged above 65 years were more sensitive to the adverse effects of PM2.5 exposure. The present findings demonstrate that short-term exposure to PM2.5 resulted in an increase in the number of outpatient visits for knee osteoarthritis in Beijing. The findings shed light on the effects of air pollution on knee osteoarthritis and could guide risk-mitigating strategies in cities such as Beijing.

Air pollution and decreased bone mineral density among Women's Health Initiative participants

“…showed that short-term exposure to PM 2.5 resulted in an increase in the number of outpatient visits for knee osteoarthritis in Beijing, suggesting potential additional air pollution-related bone damage and suggested an exposure-response relationship. 51 In studies from India, Ranzani et al. reported that PM 2.5 also was associated with lower BMD in the spine (−0.57 g per 3 μg/m 3 increase in PM 2.5 ) and hip (−0.13 g per 3 μg/m 3 ).…”

Relationship of Healthy Building Determinants With Musculoskeletal Disorders of the Extremities: A Systematic Review

“…Fifty-three eligible studies were uncovered . Twenty-six studies seemed to be eligible at preliminary review, but were deemed ineligible for the following reasons: association of MSD with HBD not assessed (n = 9) [86][87][88][89][90][91][92][93][94], HBD details not provided (n = 1) [95], HBD not assessed (n = 7) [96][97][98][99][100][101][102], independent impact of HBD could not be concluded (n = 1) [103], not indoor environment (n = 4) [104][105][106][107], not MSD (n = 3) [108][109][110], and not original research (n = 1) [111]. Sixteen studies [34,38,[47][48][49][50]58,63,67,69,70,72,73,75,78,79] uncovered in the current review were also reported in our other systematic review on HBDs and spine-related MSDs (back pain, neck pain) [13].…”

“…Fifty-three eligible studies were uncovered [ 33 - 85 ]. Twenty-six studies seemed to be eligible at preliminary review, but were deemed ineligible for the following reasons: association of MSD with HBD not assessed (n = 9) [ 86 - 94 ], HBD details not provided (n = 1) [ 95 ], HBD not assessed (n = 7) [ 96 - 102 ], independent impact of HBD could not be concluded (n = 1) [ 103 ], not indoor environment (n = 4) [ 104 - 107 ], not MSD (n = 3) [ 108 - 110 ], and not original research (n = 1) [ 111 ].…”

Associations between air pollution and multimorbidity in the UK Biobank: A cross-sectional study

“…We found that exposure to air pollution increased the likelihood of being in the multimorbidity pattern comprising painful conditions which included conditions such as joint pain, osteoarthritis, and ankylosing spondylitis. Early evidence suggests there are associations between air pollution and pain, with links found between NO 2 levels and self-rated pain in people with osteoarthritis and spondyloarthritis (34), and PM 2.5 levels and outpatient visits for osteoarthritis (35). Larger scale .…”